Results 61 to 70 of about 1,204,436 (291)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Revista Brasileira de Engenharia Agrícola e Ambiental, 2013 Foram estudadas, neste trabalho, a homogeneidade e a existência de tendências na distribuição temporal da precipitação para a microrregião do Sertão do São Francisco, no estado de Alagoas.
Henderson S. Wanderley +4 more
doaj
Environmental & Socio-economic Studies, 2023 Due to an absence of domestic certified reference materials for coal on the Polish market, an attempt was made to manufacture a new and innovative product tailored to its needs.
Więcek Katarzyna +3 more
doaj +1 more source
Homogeneity of infinite dimensional isoparametric submanifolds
, 1998 A subset S of a Riemannian manifold N is called extrinsically homogeneous if S is an orbit of a subgroup of the isometry group of N. Thorbergsson proved the remarkable result that every complete, connected, full, irreducible isoparametric submanifold of ...
Heintze, Ernst, Liu, Xiaobo
core +2 more sources
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Homogeneity of early--type galaxies across clusters
, 2003 We studied the scatter across clusters of the color of the red sequence in a representative and large sample of clusters (more than 200) detected on the Early Data Release of the Sloan Digital Sky Survey (EDR--SDSS) in the redshift range 0 ...
Abell +42 more
core +2 more sources
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Reconstructions of Serbian National Identity in the Post-Yugoslav Era: A Thematic Survey
Etnoantropološki Problemi, 2018 This paper surveys some of the challenges facing Serbia in reconstructing elements of its national identity following the break-up of Yugoslavia in the 1990s. Unlike most of the other republics that comprised the federation, Serbia fought to maintain the
Paul Moon
doaj +1 more source