Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
Cointegration Rank Test and Long Run Specification: A Note on the Robustness of Structural Demand Systems [PDF]
Private demand systems provide a practical application for analyzing identification issues in cointegration analysis. The paper conducts Montecarlo simulation experiments of cointegrated demand systems by assuming non-separability of government ...
D. Aristei, Luca Pieroni
core
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Revisiting the statistical isotropy of GRB sky distribution
The assumption of homogeneity and isotropy on large scales is one of the main hypotheses of the standard cosmology. In this paper, we test the hypothesis of isotropy from the two-point angular correlation function of 2626 gamma-ray bursts (GRB) of the ...
Alcaniz, Jailson S. +3 more
core +1 more source
Testing Homogeneity of Odds Ratio for Stratified Bilateral Correlated Data
In clinical studies such as ophthalmologic or otolaryngologic research, bilateral correlated data frequently arise when outcomes are collected from paired organs or body parts.
Xi Shen, Xueqing Zhang, Chang-Xing Ma
doaj +1 more source
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source
Testing the homogeneity of the Universe using gamma-ray bursts
In this paper, we study the homogeneity of the GRB distribution using a subsample of the Greiner GRB catalogue, which contains 314 objects with redshift ...
Li, Ming-Hua, Lin, Hai-Nan
core +1 more source
On Bartlett's Test and Lehmann's Test for Homogeneity of Variances
The purpose of this paper is to compare a modified likelihood ratio test (Bartlett [2]) with the asymptotically UMP invariant test (Lehmann [8]) for testing homogeneity of variances of $k$ normal populations. We denote these tests by the "$M$ test" and "$L$ test," respectively.
Sugiura, Nariaki, Nagao, Hisao
openaire +2 more sources
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Exact Tests for Two-Way Contingency Tables with Structural Zeros [PDF]
Fisher's exact test, named for Sir Ronald Aylmer Fisher, tests contingency tables for homogeneity of proportion. This paper discusses a generalization of Fisher's exact test for the case where some of the table entries are constrained to be zero.
Luke J. West, Robin K. S. Hankin
core +1 more source

