Results 31 to 40 of about 487,531 (216)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The distribution of the number of node neighbors in random hypergraphs

, 2013
Hypergraphs, graph generalizations where edges are conglomerates of $r$ nodes called hyperedges of rank $r\geq 2$, are excellent models to study systems with interactions that are beyond the pairwise level. For hypergraphs, the node degree $\ell$ (number
López, Eduardo
core   +1 more source

Analytical Approximations for Calculating the Escape and Absorption of Radiation in Clumpy Dusty Environments [PDF]

, 1999
We present analytical approximations for calculating the scattering, absorption and escape of nonionizing photons from a spherically symmetric two-phase clumpy medium, with either a central point source of isotropic radiation, a uniform distribution of ...
Boisse P., Eli Dwek, Frank Varosi, Hobson M. P., Hobson M. P., Pfenniger D., Wolf S.   +6 more
core   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Analysis of Varying Temperature Regimes in a Conductive Strip during Induction Heating under a Quasi-Steady Electromagnetic Field

Energies
Transition processes in a steel conductive strip are analyzed during its induction heating under a quasi-steady electromagnetic field. In particular, the temperature field in the strip is studied.
Roman Musii, Marek Lis, Petro Pukach, Andriy Chaban, Andrzej Szafraniec, Myroslava Vovk, Nataliia Melnyk   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

New homogenization approaches for stochastic transport through heterogeneous media

, 2019
The diffusion of molecules in complex intracellular environments can be strongly influenced by spatial heterogeneity and stochasticity. A key challenge when modelling such processes using stochastic random walk frameworks is that negative jump ...
Carr, Elliot J., Simpson, Matthew J.
core   +1 more source

(In-)Consistencies in the relativistic description of excited states in the Bethe-Salpeter equation [PDF]

, 1999
The Bethe-Salpeter equation provides the most widely used technique to extract bound states and resonances in a relativistic Quantum Field Theory. Nevertheless a thorough discussion how to identify its solutions with physical states is still missing. The
Abramowitz, Bijtebier, Ciafolini, Cornwall, Cutkosky, Cutkosky, Dyson, Fukui, Gell-Mann, Goldstein, Göckeler, Hawes, Ida, Kaufmann, Llewellyn Smith, Miranski, Naito, Nakanishi, Nakanishi, Nakanishi, Nieuwenhuis, Nieuwenhuis, Ohnuki, Press, Reinhard Alkofer, Roberts, Rosenfelder, Salpeter, Scarf, Schwinger, Steven Ahlig, Wick   +31 more
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source