Results 41 to 50 of about 487,531 (216)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Evaluating the phase diagram of superconductors with asymmetric spin populations

, 2006
The phase diagram of a non-relativistic fermionic system with imbalanced state populations interacting via a short-range S-wave attractive interaction is analyzed in the mean field approximation. We determine the energetically favored state for different
A. I. Larkin, A. J. Leggett, Giuseppe Nardulli, Marco Ruggieri, Massimo Mannarelli, P. Courteille   +5 more
core   +1 more source

Long-lived non-thermal states realized by atom losses in one-dimensional quasi-condensates [PDF]

, 2017
We investigate the cooling produced by a loss process non selective in energy on a one-dimensional (1D) Bose gas with repulsive contact interactions in the quasi-condensate regime.
Bouchoule, Isabelle, Johnson, A., Schemmer, M., Szigeti, S.   +3 more
core   +2 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Temperature Stabilization of Electromagnetic Wave Phase Velocity in Rectangular Waveguide with Layered Nanocomposite Ferroelectric Film

Известия высших учебных заведений России: Радиоэлектроника, 2017
A solution is obtained for propagation constant of electromagnetic wave fundamental mode in straightangle waveguide with the cross section partially filled with multilayer nanocomposite ferroelectric film (MNESEP) on a dielectric substrate. The numerical
I. G. Mironenko, A. A. Ivanov
doaj  

Exploratory Analysis of Functional Data via Clustering and Optimal Segmentation [PDF]

, 2010
We propose in this paper an exploratory analysis algorithm for functional data. The method partitions a set of functions into $K$ clusters and represents each cluster by a simple prototype (e.g., piecewise constant).
Abraham, Auger, Bellman, Bernard Hugueney, Coifman, Cottrell, Cottrell, Devroye, Fabrice Rossi, Frappart, Georges Hébrail, Healey, Huber, Jackson, Krier, Lin, Picard, Ramsay, Rose, Rossi, Saito, Stone, Tikhonov, Yves Lechevallier   +23 more
core   +3 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Cluster approximations for probabilistic systems: a new perspective of epidemiological modelling

, 2004
Especially in lattice structured populations, homogeneous mixing represents an inadequate assumption. Various improvements upon the ordinary pair approximation based on a number of assumptions concerning the higher-order correlations have been proposed ...
Albert, Barabási, Bauch, Diekmann, Dorogovtsev, Durrett, Durrett, Ellner, Faloutsos, Keeling, Keeling, Liljeros, Matsuda, Newman, Paolo De Los Rios, Pastor-Satorras, Rand, Sato, Sato, Thomas Petermann, Van Baalen, Watts   +21 more
core   +1 more source

Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. Methods Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 ...
Chandra L. Miller, Lauren N. Coffey, Shelley R. H. Mockler, Katie M. Laubscher, Carrie M. Stephan, M. Bridget Zimmerman, Katherine D. Mathews   +6 more
wiley   +1 more source

Real‐World Performance of CSF Kappa Free Light Chains in the 2024 McDonald Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Kappa free light chains (KFLCs) in the cerebrospinal fluid (CSF) have a similar performance to CSF‐restricted oligoclonal bands (OCB) for multiple sclerosis (MS) diagnosis. To help with implementation, we set out to resolve several remaining uncertainties: (1) performance in a real‐world cohort and the 2024 McDonald criteria; (2 ...
Maya M. Leibowitz, Ryan Cooper, Stefania Kaninia, Kathryn I. Challis, Will Greenway, Maria Bonello, Mahmoud Elbahnasawi, Deborah T. Shode, Dominika Gajdasik, Victor Iliev, Alison M. E. Whitelegg, Ian Galea   +11 more
wiley   +1 more source