Results 261 to 270 of about 1,306,827 (384)

Highly Selective Adsorption of Fluorinated Gases by Porous Organic Cages – Effects of Fluorinated Side‐Chains

open access: yesAdvanced Materials, EarlyView.
A systematic study of a series of porous organic cages with perfluorinated alkyl side‐chains of different lengths is presented. The structure‐property relationship of the various cages on gas sorption of highly potent greenhouse gases, such as perfluorocarbons (PFCs), sulfur hexafluoride (SF6), and nitrogen trifluoride (NF3) is investigated.
Ke Tian   +8 more
wiley   +1 more source

Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer

open access: green, 2009
Ronald Wolf   +9 more
openalex   +1 more source

Biocatalytic Construction of a Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Nucleoside Probe: Synthesis and Evaluation of 5‐Methyl‐5,6‐Dihydrothymidine

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Al‐Hilfi et al. present a biocatalytic strategy for synthesizing 5‐methyl‐5,6‐dihydrothymidine (5‐MDHT), a sensitive MRI contrast agent. The study demonstrates that recombinant enzyme catalysis offers an efficient, sustainable, and eco‐friendly alternative to traditional chemical synthesis for producing clinically relevant imaging probes.
Aimen Al‐Hilfi   +8 more
wiley   +1 more source

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg   +5 more
wiley   +1 more source

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

open access: yesNature, 2017
Weixing Zhao   +19 more
semanticscholar   +1 more source

Structural Characterization and AI‐Enhanced Modeling of a Broadly Neutralizing Camelid Antibody Against SARS‐CoV‐2 Variants

open access: yesAdvanced Therapeutics, EarlyView.
This study characterizes a camelid antibody (B10) with potent neutralizing activity against SARS‐CoV‐2 Wildtype and Omicron variants. Through binding assays, epitope mapping, pseudovirus neutralization, and AI‐driven modeling, the antibody is shown to target conserved RBD regions in a closed Spike conformation.
Katja Hanack   +13 more
wiley   +1 more source

Fuzuloparib with or without apatinib as maintenance therapy in newly diagnosed, advanced ovarian cancer (FZOCUS-1): A multicenter, randomized, double-blind, placebo-controlled phase 3 trial. [PDF]

open access: yesCA Cancer J Clin
Wu L   +56 more
europepmc   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

open access: yesAdvanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang   +6 more
wiley   +1 more source

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