Results 271 to 280 of about 1,306,827 (384)

Olaparib, durvalumab, and cyclophosphamide, and a prognostic blood signature in platinum-sensitive ovarian cancer: the randomized phase 2 SOLACE2 trial. [PDF]

Nat Commun
Lee CK, Kartikasari AER, Bound NT, Francis KE, Shield-Artin K, Bedo J, Nesic K, Diamante K, O'Connell RL, Madondo M, Cox M, Davies C, Deceneux C, Goodchild G, Jarratt A, Cassar E, Amer H, Kariyawasam UGIU, Lee YC, Lombard J, Baron-Hay S, Antill Y, Shannon C, Selva-Nayagam S, Beale P, Zebic D, Simon S, Linaker A, Quinn MA, Papenfuss AT, Wakefield MJ, Vandenberg CJ, Friedlander M, Scott CL, Plebanski M.   +34 more
europepmc   +1 more source

Homologous targeted neutrophils-liposome system for pyroptosis-enhanced antitumor immunotherapy of triple-negative breast cancer

Ge Gao, Xiaodi Xu, Xiaoyang Liu, Yao‐Wen Jiang, Meng Wang, Tong Su, Jiaxuan Chen, Menghua Xue, Weixiang Zhong, Yuxin Chen, Peng Jiang, Junnian Zheng, Gang Wang   +12 more
openalex   +1 more source

HERV‐K TM Subunit Elicits CD8+ T Cell Anergy and Tumor Immune Evasion via Targeting CD3 Coreceptor ε in AML and PDAC

Advanced Science, EarlyView.
Novel viral immune checkpoint K‐TM subunit is aberrantly expressed in CD8+ T cells and enriched in sera of cancer patients, inducing CD8+ T cell anergy and eliciting potent tumor immune escape in mouse model. Mechanistically, K‐TM directly targets and induces the phosphorylation of CD3ε receptor.
Mengyuan Li, Shuwen Zheng, Qinyuan Gong, Zhaoxing Wu, Wen Lei, Wanyue Cao, Ping Wang, Xuzhao Zhang, Wenbin Qian, Yun Liang, Ying Lu, Fenglin Li, Qi Zhang, Rongzhen Xu   +13 more
wiley   +1 more source

Extensive cultivation of human gut phages revealing undescribed <i>Bacteroidaceae</i> phages. [PDF]

Gut Microbes
Liu Z, Yang Y, Mao S, Wang Z, Zhu Q, Yuan Y, Xiang Y.   +6 more
europepmc   +1 more source

Lnc‐HZ05 Suppresses Trophoblast Cell Migrasome Formation by Disrupting TGFβ2 Pathway in Unexplained Recurrent Miscarriage

Advanced Science, EarlyView.
TGFβ2 signaling‐mediated migration/invasion and migrasome formation are suppressed in recurrent miscarriage (RM) versus healthy control villous tissues and are negatively associated with unexplained RM. In mechanism, TGFβ2 promotes trophoblast cell migration/invasion and migrasome formation, all of which are suppressed by lnc‐HZ05. In details, lnc‐HZ05
Weina Chen, Ying Zhang, Zimeng Zhao, Yang Yang, Geng Guo, Yi Sun, Tao Zhang, Zhihong Zhang, Liqin Zeng, Wenxin Huang, Qingjun Shen, Ruining Han, Zhaohui He, Depeng Zhao, Huidong Zhang   +14 more
wiley   +1 more source

Homologous Recombination Deficiency and Survival in Ovarian High-Grade Serous Carcinoma by Self-Reported Race. [PDF]

Cancer Epidemiol Biomarkers Prev
Lawson-Michod KA, Johnson CE, Barnard ME, Davidson NR, Collin LJ, Nix DA, Huff CD, Berchuck A, Salas LA, Greene CS, Marks JR, Peres LC, Doherty JA, Schildkraut JM.   +13 more
europepmc   +1 more source

Repression of BET activity sensitizes homologous recombination–proficient cancers to PARP inhibition

Science Translational Medicine, 2017
Lu Yang, Youyou Zhang, Weiwei Shan, Zhongyi Hu, Jiao Yuan, Jingjiang Pi, Yueying Wang, L. Fan, Zhaoqing Tang, Chunsheng Li, Xiaowen Hu, J. Tanyi, Yi Fan, Qihong Huang, K. Montone, C. Dang, Lin Zhang   +16 more
semanticscholar   +1 more source

Effect of Additional Terminal Residues on the Folding and Unfolding Dynamics of Cold Shock Protein

Advanced Science, EarlyView.
Enhancing protein stability through N‐ and C‐terminal modifications presents a safe and cost‐effective strategy. We investigated this by combining single‐molecule magnetic tweezers experiments and molecular dynamics simulations to study the folding and unfolding dynamics of CSP with various appended residues (LE‐CSP‐GS, KL‐CSP‐GS, KL‐CSP‐LE).
Dan Hu, Yang Wang, Huanjie Jiang, Hai Pan, Yunqiang Bian, Weitong Ren, Hu Chen, Zilong Guo, Yanwei Wang   +8 more
wiley   +1 more source

A Multicenter Propensity Score Matching Study of Homologous Convective Volume (HCV): A New Comprehensive Parameter for Dialysis Dose That Improves Survival. [PDF]

Cureus
Quinchuela J, Tamayo G, Benavides N, Mora-Bravo F.   +3 more
europepmc   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source