Results 271 to 280 of about 1,276,040 (389)

Mucosal immune response in pigs following the primary and secondary exposure to porcine epidemic diarrhea virus genogroups G1 and G2. [PDF]

open access: yesSci Rep
Jermsutjarit P   +8 more
europepmc   +1 more source

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

open access: yesNature, 2017
Weixing Zhao   +19 more
semanticscholar   +1 more source

Genetic Engineering Methods in Primary T Cells

open access: yesAdvanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

<i>RAD51</i> and <i>PALB2</i> in precision oncology: Clinical implications for HRD associated breast and ovarian cancers (Review). [PDF]

open access: yesInt J Oncol
Kausar MA   +10 more
europepmc   +1 more source

Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery

open access: yesAdvanced Science, EarlyView.
Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou   +8 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

open access: yesAdvanced Science, EarlyView.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu   +7 more
wiley   +1 more source

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