Results 281 to 290 of about 1,306,827 (384)

Comprehensive genomic profiling for homologous recombination deficiency guides PARP inhibitor therapy recommendations in ovarian cancer. [PDF]

Pathol Oncol Res
Inci A, Witzel I, Moch H, Rahmani-Khajouei S, Zoche M, Samartzis EP.   +5 more
europepmc   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Evaluation of intraductal carcinoma and invasive cribriform carcinoma as predictors of genetic mutations in systemic treatment-naïve prostate cancer patients. [PDF]

BMC Cancer
Lee S, Park I, Ahn B, Lim B, Kim JK, You D, Jeong IG, Hong JH, Ahn H, Suh J.   +9 more
europepmc   +1 more source

Cosheaves and homology [PDF]

Pacific Journal of Mathematics, 1968
openaire   +3 more sources

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

Optimized multi-epitope neoantigen human cytomegalovirus vaccine based on adenovirus vectors elicits potent antiviral immunity. [PDF]

Front Immunol
Jiang S, Zhang X, Zhao H, Liu F, Li Z, Yang X, Liu W, Lv J, Zhang Y, Zhang Y, Yu Y, Wang B, Wang Y.   +12 more
europepmc   +1 more source

PHR‐Mediated Pi Starvation Response Mobile Messenger RNAs Represent Noncoding Transcripts in Recipient Tissues

Advanced Science, EarlyView.
Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong, Shuman Wang, Chao Liu, Lulu Qiao, Kai Liu, Qiongli Jin, Xiaorong Mo, Xingxing Shen, Keke Yi, Zhiye Wang   +9 more
wiley   +1 more source

Comprehensive assessment of homologous recombination deficiency via simultaneous methylation and mutation analysis in epithelial ovarian cancer: implications for PARP inhibitors efficacy. [PDF]

Biomark Res
Dong L, Wu H, Li N, Li W, Song Y, Xiong Y, Yin H, Fang H, Chen R, Yi X, Huang J, Ying J.   +11 more
europepmc   +1 more source

Novel vectors for homologous recombination strategies in mouse embryonic stem cells: An ES cell line expressing EGFP under control of the 5T4 promoter

, 2007
Flor M. Pérez-Campo, Helen Spencer, Rhoderick H. Elder, Peter L. Stern, Christopher M. Ward   +4 more
openalex   +2 more sources

A mechanism for the suppression of homologous recombination in G1 cells

Nature, 2015
Alexandre Orthwein, S. M. Noordermeer, M. D. Wilson, S. Landry, Radoslav I. Enchev, Alana Sherker, Meagan M. Munro, J. Pinder, Jayme Salsman, G. Dellaire, B. Xia, M. Peter, D. Durocher   +12 more
semanticscholar   +1 more source