Results 31 to 40 of about 621,494 (219)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Chemical Compositions, Traditional Applications, and Biological Activities of Gnaphalium affine D. Don: A Comprehensive Review

Molecules
Gnaphalium affine D. Don (G. affine), a genus within the genus Gnaphalium of the Asteraceae family, is recognized as a significant medicinal resource. Phytochemical investigations identified various bioactive compounds in G. affine, including flavonoids,
Chen Ding, Yimiao Zhou, Lin Yang, Liquan Zhou, Zuowei Xiao   +4 more
doaj   +1 more source

Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study

Emerging Microbes and Infections, 2022
A COVID-19 booster vaccination is being comprehensively evaluated globally due to the emerging concern of reduced protection rate of previous vaccination and circulating Variants of Concern (VOC).
Jingwen Ai, Yi Zhang, Haocheng Zhang, Qiran Zhang, Zhangfan Fu, Ke Lin, Jieyu Song, Yuanhan Zhao, Mingxiang Fan, Hongyu Wang, Yang Zhou, Xiaohua Chen, Chao Qiu, Wenhong Zhang   +13 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Efficacy of Double versus Single Homologous Intrauterine Insemination in Mild Male Factor Infertility and Pregnancy Outcome: A Randomised Controlled Trial [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Intrauterine Insemination (IUI) is a cost-effective, minimally invasive, and widely accepted Assisted Reproductive Technology (ART) procedure used to treat infertility.
M Roopa, Sharath Kumar, Leena Kamath, Voorkara Udayashree, Sahana N Naik   +4 more
doaj   +1 more source

Antifatigue Effect of Panax Notoginseng Leaves Fermented With Microorganisms: In-vitro and In-vivo Evaluation

Frontiers in Nutrition, 2022
Fatigue is a common physiological phenomenon caused by many complicated factors. Excessive fatigue will lead to a series of uncomfortable reactions and damage body health.
Min Yang, Min Yang, Liang Tao, Liang Tao, Liang Tao, Cun-Chao Zhao, Cun-Chao Zhao, Zi-Lin Wang, Zi-Lin Wang, Zhi-Jin Yu, Zhi-Jin Yu, Wen Zhou, Yan-Long Wen, Yan-Long Wen, Ling-Fei Li, Ling-Fei Li, Yang Tian, Yang Tian, Yang Tian, Jun Sheng, Jun Sheng   +20 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Estudo comparativo de propriedades biomecânicas da porção central do tendão calcâneo congelado e a fresco Comparative study on biomechanical properties of the central portion of frozen and fresh calcaneus tendon

Acta Ortopédica Brasileira, 2007
Métodos de armazenamento de aloenxertos podem alterar certas características mecânicas dos tecidos. Com o objetivo de analisar a influência do fenômeno de congelamento e do tempo de armazenamento sobre as propriedades biomecânicas de tendões, os autores ...
Rodrigo Bezerra de Menezes Reiff, Alberto Tesconi Croci, Raul Bolliger Neto, César Augusto Martins Pereira   +3 more
doaj   +1 more source