Results 111 to 120 of about 304,895 (349)

Reducing MSH4 copy number prevents meiotic crossovers between non-homologous chromosomes in Brassica napus

Nature Communications, 2019
Non-homologous crossovers impair correct chromosome segregation in allopolyploids. Here the authors show that most non-homologous crossovers in Brassica napus arise from MSH4-dependent recombination and provide evidence that post-polyploidization ...
Adrián Gonzalo, Marie-Odile Lucas, Catherine Charpentier, Greta Sandmann, Andrew Lloyd, Eric Jenczewski   +5 more
doaj   +1 more source

Measuring Homologous Recombination Rates between Chromosomal Locations in Salmonella

Bio-Protocol, 2019
Homologous recombination between two similar DNA molecules, plays an important role in the repair of double-stranded DNA breaks. Recombination can occur between two sister chromosomes, or between two locations of similar sequence identity within the same
Gerrit Brandis, Sha Cao, Diarmaid Hughes   +2 more
doaj   +1 more source

CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis. [PDF]

PLoS Genetics, 2008
The synaptonemal complex (SC), a tripartite proteinaceous structure that forms between homologous chromosomes during meiosis, is crucial for faithful chromosome segregation.
Sarit Smolikov, Kristina Schild-Prüfert, Mónica P Colaiácovo   +2 more
doaj   +1 more source

Direct pairing of homologous DNA double helices may involve the B-to-C form transition [PDF]

arXiv, 2022
In many organisms, homologous (or repetitive) chromosomal regions can associate or/and undergo concerted epigenetic changes in the absence of DNA breakage and recombination. The direct specific pairing of DNA duplexes with similar nucleotide sequences represents an attractive mechanism for recognizing such regions. Whereas the pairing of B-DNA duplexes
arxiv  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements [PDF]

, 2015
Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability.
A Janssen, A Letessier, AT Watson, AT Watson, BJ Brewer, C Lukas, D Branzei, E Ampatzidou, E Tsang, EK Schwartz, HD Lindsay, I Miyabe, J Bartkova, J Matos, JA Harrigan, JM Murray, K Mizuno, K Mizuno, K Tanaka, KL Chan, KL Chan, LJ Gaskell, MN Boddy, NC Walworth, O Limbo, P Huertas, PM Dehe, RA Burrell, S Lambert, S Lambert, S Minocherhomji, S Sarbajna, S Ying, SC Ip, SG Durkin, SM Mirkin, T Caspari, V Naim, VG Gorgoulis, X Li   +39 more
core   +1 more source

Chromosomal Structural Abnormality Diagnosis by Homologous Similarity [PDF]

Pathogenic chromosome abnormalities are very common among the general population. While numerical chromosome abnormalities can be quickly and precisely detected, structural chromosome abnormalities are far more complex and typically require considerable efforts by human experts for identification.
arxiv   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Antler tine homologies and cervid systematics: A review of past and present controversies with special emphasis on Elaphurus davidianus

The Anatomical Record, Volume 306, Issue 1, Page 5-28, January 2023., 2023
Abstract Antlers are the most conspicuous trait of cervids and have been used in the past to establish a classification of their fossil and living representatives. Since the availability of molecular data, morphological characters have generally become less important for phylogenetic reconstructions.
Nicola S. Heckeberg, Frank E. Zachos, Uwe Kierdorf   +2 more
wiley   +1 more source

Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts

Scientific Reports, 2022
Single-cell Hi-C analysis of diploid human cells is difficult because of the lack of dense chromosome contact information and the presence of homologous chromosomes with very similar nucleotide sequences.
Yoshito Hirata, Arisa H. Oda, Chie Motono, Masanori Shiro, Kunihiro Ohta   +4 more
doaj   +1 more source