Results 121 to 130 of about 297,547 (335)

DNA DSB repair pathway choice: an orchestrated handover mechanism [PDF]

, 2014
DNA double strand breaks (DSBs) are potential lethal lesions but can also lead to chromosome rearrangements, a step promoting carcinogenesis. DNA non-homologous end-joining (NHEJ) is the major DSB rejoining process and occurs in all cell cycle stages ...
A Kakarougkas, Friedberg EC, Haynes RH, Jeggo PA, P A Jeggo, Wilson JH   +5 more
core   +1 more source

Lithium Exposure Causes Trophoblast Cuproptosis by Upregulating FOXO1/STEAP4 Axis in Unexplained Miscarriage

Advanced Science, EarlyView.
Li exposure up‐regulates FOXO1 expression levels and thus promotes FOXO1‐mediated STEAP4 transcription, up‐regulating STEAP4 levels. Subsequently, STEAP4 up‐regulates intracellular Cu+ ion levels and causes cuproptosis, which further induces miscarriage.
Shuaishuai Xing, Yanbing Lin, Yi Sun, Xiaoping Yue, Qigang Fan, Jisheng Nie, Zhihong Zhang, Yajing Liu, Juntang Yang, Qingzheng Kang, Yanxin Wang, Haijun Yan, Chan Tian, Ying Chang, Huidong Zhang   +14 more
wiley   +1 more source

Meiotic chromosome movement: what’s lamin got to do with it?

Nucleus, 2019
Active meiotic chromosome movements are a universally conserved feature. They occur at the early stages of prophase of the first meiotic division and support the chromosome pairing process by (1) efficiently installing the synaptonemal complex between ...
Dimitra Paouneskou, Verena Jantsch
doaj   +1 more source

Synteny analysis in Rosids with a walnut physical map reveals slow genome evolution in long-lived woody perennials. [PDF]

, 2015
BackgroundMutations often accompany DNA replication. Since there may be fewer cell cycles per year in the germlines of long-lived than short-lived angiosperms, the genomes of long-lived angiosperms may be diverging more slowly than those of short-lived ...
Aradhya, Mallikarjuna, Dandekar, Abhaya M, Dvorak, Jan, Leslie, Charles A, Li, Pingchuan, Luo, Ming-Cheng, McGuire, Patrick E, Wang, Ji-Rui, You, Frank M, Zhu, Tingting   +9 more
core   +2 more sources

A Blast‐Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia‐Lyase in Rice

Advanced Science, EarlyView.
The NLR protein PibH8 interacts with phenylalanine ammonia‐lyase OsPAL1 and E3 ubiquitin ligase OsFBK16. Through competitive binding, PibH8 weakens the interaction between OsFBK16 and OsPAL1, thereby reducing the degradation of OsPAL1 by OsFBK16. The Hap1 allele of PibH8 exhibits a higher expression level than Hap2, thus accumulating more PibH8 protein,
Denghao Xiang, Haifu Tu, Yang Yuan, Yilong Yao, Wanwen Liao, Huaijun Wang, Yu Yan, Yao Wang, Yu Chen, Di Liu, Qingya Lv, Haidong He, Honghong Hu, Xuelei Lai, Meng Yuan, Haiyan Xiong, Faming Dong, Lizhong Xiong   +17 more
wiley   +1 more source

Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us [PDF]

, 2009
The DNA damage response (DDR) mechanisms represent a vital line of defense against exogenous and endogenous DNA damage to enhance two distinct outcomes, survival and the maintenance of genomic stability. The latter is critical for cancer avoidance.
Jeggo, Peggy A.
core   +2 more sources

HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF‐κB/SOD2 Signaling Pathway

Advanced Science, EarlyView.
HIGD1A maintains redox homeostasis in granulosa cells by modulating SOD2‐mediated dismutation of superoxide into H2O2, which is cleared by CAT and GPX enzymes. However, reduced HIGD1A activates the NF‐κB pathway and upregulates SOD2, leading to intracellular H2O2 accumulation due to impaired clearance.
Huiying Li, Siying Cai, Hongbei Mu, Tianli Chang, Xiaofei Wang, Tianyu Tang, Tengyun Dong, Yu Zhang, Ling Zhang, Huaibiao Li, Liquan Zhou, Wenpei Xiang   +11 more
wiley   +1 more source

OsRAD17 Is Required for Meiotic Double-Strand Break Repair and Plays a Redundant Role With OsZIP4 in Synaptonemal Complex Assembly

Frontiers in Plant Science, 2018
The repair of SPO11-dependent double-strand breaks (DSBs) by homologous recombination (HR) ensures the correct segregation of homologous chromosomes. In yeast and human, RAD17 is involved in DNA damage checkpoint control and DSB repair.
Qing Hu, Qing Hu, Chao Zhang, Chao Zhang, Zhihui Xue, Lijun Ma, Wei Liu, Yi Shen, Bojun Ma, Zhukuan Cheng, Zhukuan Cheng   +10 more
doaj   +1 more source

Genetical behavior of heteromorphic homologous chromosomes of circotettix (Orthoptera) [PDF]

, 1921
E. Eleanor Carothers
openalex   +1 more source

MJL-1 is a nuclear envelope protein required for homologous chromosome pairing and regulation of synapsis during meiosis in C. elegans. [PDF]

Sci Adv, 2023
Kim HJ, Liu C, Zhang L, Dernburg AF.
europepmc   +1 more source