Results 221 to 230 of about 304,895 (349)

Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis

open access: yesiMeta, Volume 1, Issue 4, December 2022., 2022
Intestinal stem cells (ISCs) are protected by their niche and are regulated by Wnt, bone morphogenetic protein, and Notch. ISCs and their relationship with intestinal microbiota provide a feasible pathway to alleviate intestinal diseases. Diverse bacteria‐related postbiotics regulate ISCs and maintain their homeostasis.
Ning Ma   +3 more
wiley   +1 more source

CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms. [PDF]

open access: yesLife Sci Alliance, 2019
Brunner E   +8 more
europepmc   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

open access: yesBMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan   +12 more
wiley   +1 more source

Developmental regulation of SPO13, a gene required for separation of homologous chromosomes at meiosis I.

open access: green, 1987
H T Wang   +4 more
openalex   +1 more source

Telomere‐to‐telomere reference genome reveals subgenome divergence and large structural variants in Capsella bursa‐pastoris (Brassicaceae)

open access: yesBiological Diversity, EarlyView.
This study presents a subgenome‐resolved telomere‐to‐telomere reference genome of Capsella bursa‐pastoris, named Cbp_T2T, constructed using PacBio HiFi reads, Nanopore ultra‐long reads, and Hi‐C data. Notable divergences were observed between its subgenomes, and comparative genomics identified two large inversions within the species.
Xin Liu   +4 more
wiley   +1 more source

Characterization of large transgene integrations in Chinese hamster ovary cells using a bioengineered mammalian transposase

open access: yesBiotechnology Progress, EarlyView.
Abstract We present the first use of a bioengineered mammalian transposase system derived from Myotis lucifugus (bMLT) for integration of expression vectors into the CHO genome, focusing on GFP and trastuzumab production. Initially, CHO‐K1 cells are transfected with a GFP reporter and varying amounts of bMLT DNA or mRNA.
Nicolas Marx   +10 more
wiley   +1 more source

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