Results 231 to 240 of about 611,533 (294)

The Origin and the Adaptive Function of Genetic Recombination in Sexual Reproduction. [PDF]

Genes (Basel)
Bernstein C, Bernstein H.
europepmc   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

An overview of recent advances on wheat homologous and homoeologous recombination. [PDF]

J Exp Bot
Sourdille P, Higgins JD, Serra H.
europepmc   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

The HORMA-domain protein ASY1 recruits the plant-specific cyclin SDS to promote DMC1-mediated meiotic recombination. [PDF]

Plant Cell
Cai B, Yuan X, Cao F, Luo Y, Zhang Y, Zhuang J, Geng M, Chu L, Schnittger A, Yang C.   +9 more
europepmc   +1 more source

Inverse Design of Copolyamides via Sequence‐Sensitive Multifidelity Hybrid Models and Teacher–Student Genetic Algorithm

Materials Genome Engineering Advances, EarlyView.
A sequence‐sensitive multi‐fidelity hybrid modeling framework combined with a teacher‐student genetic algorithm enables the inverse design of copolyamides. The hybrid model balances prediction accuracy, sequence‑sensitivity, and computational cost. A two‑tier genetic algorithm can efficiently identify the monomer structures and ratios of copolyamides ...
Sheng Chen, Chaoran Huang, Jianan Hong, Yuquan He, Yuemeng Qiao, Yang Zhao, Siqin Song, Jiaping Lin, Liang Gao   +8 more
wiley   +1 more source

Detailed re-analysis of satellitome mapping facilitated by the telomere-to-telomere (T2T) assembly of bread wheat genome. [PDF]

Plant Mol Biol
Garrido-Ramos MA, Prieto P.
europepmc   +1 more source

ISAba1‐mediated crp‐osmC amplification enhances host‐associated fitness in Acinetobacter baumannii

mLife, EarlyView.
Abstract Acinetobacter baumannii is a pathogen, highly adaptable to both hospital‐ and host‐associated environments. Understanding the genetic mechanisms underlying its adaptability is critical for controlling its persistence. Our study identified the crp‐osmC gene cluster, flanked by ISAba1 elements, as a significant genetic structure undergoing ...
Da‐Wei Wei, Jiangqing Huang, Hailing Fang, Xinyu Wang, Gang Zhang, Chao Wang, Yuqin Song, Jie Feng   +7 more
wiley   +1 more source

Shaping CDK4/6 Inhibitor Resistance: BRCA2 Germline Alterations Bias toward RB1 Inactivation. [PDF]

Cancer Res
Napolitano F, Hanker AB.
europepmc   +1 more source

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source