Results 221 to 230 of about 147,193 (248)
Some of the next articles are maybe not open access.
The Plant Journal, 2000
SummaryThe Arabidopsis MIM gene encodes a protein belonging to the SMC family (structure maintenance of chromosomes) which is required for intrachromosomal homologous recombination (ICR). Both ICR and MIM gene expression are enhanced by DNA‐damaging treatments, suggesting that MIM is a factor limiting DNA repair by homologous recombination (HR) under ...
Hanin, M. +3 more
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SummaryThe Arabidopsis MIM gene encodes a protein belonging to the SMC family (structure maintenance of chromosomes) which is required for intrachromosomal homologous recombination (ICR). Both ICR and MIM gene expression are enhanced by DNA‐damaging treatments, suggesting that MIM is a factor limiting DNA repair by homologous recombination (HR) under ...
Hanin, M. +3 more
openaire +3 more sources
Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1
Blood, 2002AbstractDecisions about cell survival or death are central components of adaptive immunity and occur at several levels in immune system development and function. The Bcl-2 family of homologous proteins plays an important role in these decisions in lymphoid cells.
Peter I, Chuang +5 more
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Overexpression of cyclin E does not influence homologous recombination in Chinese hamster cells
Biochemical and Biophysical Research Communications, 2002Overexpressed cyclin E in tumours is a prognosticator for poor patient outcome. Cells that overexpress cyclin E have been shown to be impaired in S-phase progression and exhibit genetic instability that may drive this subset of cancers. However, the origin for genetic instability caused by cyclin E overexpression is unknown.
Cecilia, Lundin +2 more
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Phytochemistry, 2017
Ganoderic acids (GAs) in Ganoderma lingzhi exhibit anticancer and antimetastatic activities. GA yields can be potentially improved by manipulating G. lingzhi through genetic engineering. In this study, a putative lanosterol synthase (LS) gene was cloned and overexpressed in G. lingzhi. Results showed that its overexpression (OE) increased the ganoderic
De-Huai, Zhang +5 more
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Ganoderic acids (GAs) in Ganoderma lingzhi exhibit anticancer and antimetastatic activities. GA yields can be potentially improved by manipulating G. lingzhi through genetic engineering. In this study, a putative lanosterol synthase (LS) gene was cloned and overexpressed in G. lingzhi. Results showed that its overexpression (OE) increased the ganoderic
De-Huai, Zhang +5 more
openaire +2 more sources
Leukemia & Lymphoma, 2004
To clarify the mechanism of progression and acquired drug resistance of leukemia, we searched for an overexpressed gene in drug-resistant leukemia cells and identified an approximately 5-kb transcript by using the subtraction method. The nucleotide sequence of the gene was highly homologous to those of human endogenous retrovirus (HERV) transcripts ...
Haruko, Iwabuchi +6 more
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To clarify the mechanism of progression and acquired drug resistance of leukemia, we searched for an overexpressed gene in drug-resistant leukemia cells and identified an approximately 5-kb transcript by using the subtraction method. The nucleotide sequence of the gene was highly homologous to those of human endogenous retrovirus (HERV) transcripts ...
Haruko, Iwabuchi +6 more
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Journal of Cellular Physiology, 2000
The clinical efficacy of therapeutic complement (C)-activating monoclonal antibodies (mAb) to melanoma-associated antigens can be impaired by the levels of expression of C-inhibitory molecules on neoplastic cells. Protectin (CD59) is a glycosylphosphatidylinositol (GPI)-anchored cell membrane glycoprotein, acting as terminal regulator of C cascade ...
Coral S +10 more
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The clinical efficacy of therapeutic complement (C)-activating monoclonal antibodies (mAb) to melanoma-associated antigens can be impaired by the levels of expression of C-inhibitory molecules on neoplastic cells. Protectin (CD59) is a glycosylphosphatidylinositol (GPI)-anchored cell membrane glycoprotein, acting as terminal regulator of C cascade ...
Coral S +10 more
openaire +3 more sources
Process Biochemistry, 2013
Abstract A polygalacturonate lyase (PGL), PelA, was purified from the culture broth of Bacillus subtilis 7-3-3, with a molecular weight, optimal temperature, and pH of approximately 45 kDa, 55 °C, and 9.4, respectively. The PGL gene ( pelA ) was homologously overexpressed in B.
Jian Zhao, Xuezhi Li, Fenfen Guo
exaly +2 more sources
Abstract A polygalacturonate lyase (PGL), PelA, was purified from the culture broth of Bacillus subtilis 7-3-3, with a molecular weight, optimal temperature, and pH of approximately 45 kDa, 55 °C, and 9.4, respectively. The PGL gene ( pelA ) was homologously overexpressed in B.
Jian Zhao, Xuezhi Li, Fenfen Guo
exaly +2 more sources
Overexpression of the Csk homologous kinase facilitates phosphorylation of Akt/PKB in MCF-7 cells
International Journal of Oncology, 2002The serine/threonine kinase Akt has recently been the focus of intense research. Akt activation requires the phosphorylation of both Thr-308 and Ser-473. Src kinase was shown to induce activation of Akt, while Lyn kinase seems to inhibit this activation. In the present study, we investigated the effect of overexpressing the Csk homologous kinase (CHK),
Radoslaw, Zagozdzon +3 more
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A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines
Gene, 1998The Cdc7 protein kinase of Saccharomyces cerevisiae is a critical regulator of several aspects of DNA metabolism and cell cycle progression. We describe the isolation of a human gene encoding a Cdc7 homolog. The Cdc7Hs protein sequence is 27% identical to that of the yeast protein, includes features unique to yeast Cdc7, and contains all conserved ...
G F, Hess +5 more
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Arthritis & Rheumatism, 1999
To study the expression of the chaperone family of J proteins in the synovial tissue of patients with rheumatoid arthritis (RA) or osteoarthritis.Rabbit antibodies specific for a synthetic peptide (pHSJ1: EAYEVLSDKHKREIYD), representing the most conserved part of all J domains thus far identified--among them the Drosophila tumor suppressor Tid56--were ...
Kurzik-Dumke, Ursula +3 more
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To study the expression of the chaperone family of J proteins in the synovial tissue of patients with rheumatoid arthritis (RA) or osteoarthritis.Rabbit antibodies specific for a synthetic peptide (pHSJ1: EAYEVLSDKHKREIYD), representing the most conserved part of all J domains thus far identified--among them the Drosophila tumor suppressor Tid56--were ...
Kurzik-Dumke, Ursula +3 more
openaire +2 more sources