Results 61 to 70 of about 147,193 (248)

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

MiR-506 suppresses proliferation, migration, and invasion of melanoma cells by modulating EMT and DNA damage homologous recombination repair pathway

Pifu-xingbing zhenliaoxue zazhi
[Objective] To investigate the biological function of miR-506 in malignant melanoma and its regulatory mechanism on mesenchymal epithelial transition (MET) and DNA damage homologous recombination repair pathway.
LI Ting, XIANG Lijie, FU Laihua, HAO Mengze, LIU Xinyue, YANG Jilong   +5 more
doaj   +1 more source

A tuber mustard AP2/ERF transcription factor gene, BjABR1, functioning in abscisic acid and abiotic stress responses, and evolutionary trajectory of the ABR1 homologous genes in Brassica species [PDF]

PeerJ, 2018
The AP2/ERF superfamily of transcription factors is one of the largest transcription factor families in plants and plays an important role in plant development processes and stress responses. In this study, BjABR1, an AP2/ERF superfamily gene, from tuber
Liuxin Xiang, Chao Liu, Jingzhi Luo, Lin He, Yushan Deng, Jie Yuan, Chaofeng Wu, Yingfan Cai   +7 more
doaj   +2 more sources

TheFragaria vescaHomolog of SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 Represses Flowering and Promotes Vegetative Growth [PDF]

The Plant Cell, 2013
AbstractIn the annual long-day plant Arabidopsis thaliana, SUPPRESSOR OF OVEREXPRESSION OF CONSTANS1 (SOC1) integrates endogenous and environmental signals to promote flowering. We analyzed the function and regulation of the SOC1 homolog (Fragaria vesca [Fv] SOC1) in the perennial short-day plant woodland strawberry (Fragaria vesca).
Katriina, Mouhu, Takeshi, Kurokura, Elli A, Koskela, Victor A, Albert, Paula, Elomaa, Timo, Hytönen   +5 more
openaire   +2 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

MARCO is associated with radiosensitivity in lung cancer through modulation of Hippo signaling

Immunobiology
Lung cancer remains a significant global health challenge, with radiotherapy serving as a cornerstone of treatment. However, the development of resistance to radiation therapy poses a major hurdle in effective disease management.
Zhenfeng Zong, Guojie Tang, Guo Yu, Fanyi Kong   +3 more
doaj   +1 more source

FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

Cell Reports, 2020
Summary: 53BP1 plays a central role in dictating DNA repair choice between non-homologous end joining (NHEJ) and homologous recombination (HR), which is important for the sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis) of BRCA1-deficient ...
Mengfan Tang, Xu Feng, Guangsheng Pei, Mrinal Srivastava, Chao Wang, Zhen Chen, Siting Li, Huimin Zhang, Zhongming Zhao, Xu Li, Junjie Chen   +10 more
doaj   +1 more source

Homologous overexpression of rfaH in E. coli K4 improves the production of chondroitin-like capsular polysaccharide [PDF]

Microbial Cell Factories, 2013
Glycosaminoglycans, such as hyaluronic acid, heparin, and chondroitin sulfate, are among the top ranked products in industrial biotechnology for biomedical applications, with a growing world market of billion dollars per year. Recently a remarkable progress has been made in the development of tailor-made strains as sources for the manufacturing of such
CIMINI, Donatella, DE ROSA, Mario, Carlino E, Ruggiero A, SCHIRALDI, Chiara   +4 more
openaire   +3 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells

Neoplasia: An International Journal for Oncology Research, 2005
The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to aggressive and metastatic breast cancer.
Michael Zeidler, Sooryanarayana Varambally, Qi Cao, Arul M. Chinnaiyan, David O. Ferguson, Sofia D. Merajver, Celina G. Kleer   +6 more
doaj   +1 more source