Results 41 to 50 of about 147,193 (248)

Bub3 is a spindle assembly checkpoint protein regulating chromosome segregation during mouse oocyte meiosis. [PDF]

PLoS ONE, 2009
In mitosis, the spindle assembly checkpoint (SAC) prevents anaphase onset until all chromosomes have been attached to the spindle microtubules and aligned correctly at the equatorial metaphase plate.
Mo Li, Sen Li, Ju Yuan, Zhen-Bo Wang, Shao-Chen Sun, Heide Schatten, Qing-Yuan Sun   +6 more
doaj   +1 more source

Overexpression of the NEK8 kinase inhibits homologous recombination

DNA Repair
ABSTRACT Homologous recombination maintains genome stability by repairing double strand breaks and protecting replication fork stability. Defects in homologous recombination results in cancer predisposition but can be exploited due to increased sensitivity to certain chemotherapeutics such as PARP inhibitors.
Joshua L. Turner, Georgia Moore, Tyler J. McCraw, Jennifer M. Mason   +3 more
openaire   +3 more sources

Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by β‐catenin/TCF [PDF]

Cancer Science, 2008
The Drosophila Notum gene, which is regulated by the Wingless pathway, encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. In comparative analysis of the gene expression profiles in primary human hepatocellular carcinomas (HCC) and normal organs, we observed that the ...
Yuichi, Torisu, Akira, Watanabe, Aya, Nonaka, Yutaka, Midorikawa, Masatoshi, Makuuchi, Takahiro, Shimamura, Haruhiko, Sugimura, Atsushi, Niida, Tetsu, Akiyama, Hiroko, Iwanari, Tatsuhiko, Kodama, Mikio, Zeniya, Hiroyuki, Aburatani   +12 more
openaire   +2 more sources

Overexpression of associated with altered genome and poor survival in selected types of human cancer

Tumor Biology, 2020
Base excision repair, which is initiated by the DNA N -glycosylase proteins, is the frontline for repairing potentially mutagenic DNA base damage. Several base excision repair genes are deregulated in cancer and affect cellular outcomes to chemotherapy ...
Oanh TN Tran, Serkalem Tadesse, Christopher Chu, Dawit Kidane   +3 more
doaj   +1 more source

Small-Molecule Inhibitors Targeting FEN1 for Cancer Therapy

Biomolecules, 2022
DNA damage repair plays a key role in maintaining genomic stability and integrity. Flap endonuclease 1 (FEN1) is a core protein in the base excision repair (BER) pathway and participates in Okazaki fragment maturation during DNA replication.
Fan Yang, Zhigang Hu, Zhigang Guo
doaj   +1 more source

Overexpression of a Ran GTPase homologous gene, FaRan from tall fescue, in transgenic Arabidopsis

Biologia Plantarum, 2011
We isolated and characterized a novel Ran GTPase homologous gene, FaRan from tall fescue (Festuca arundinacea Schreb.). Reverse transcriptase polymerase chain reaction (RT-PCR) analysis indicated that FaRan is broadly expressed in old mature leaves ...
S. H. Lü, Y. L. Fan, C. X. Jin
doaj   +1 more source

Improved γ-linolenic acid production in Mucor circinelloides by homologous overexpressing of delta-12 and delta-6 desaturases

Microbial Cell Factories, 2017
Background γ-Linolenic acid (GLA) is important because of its nutritional value and medicinal applications. Although the biosynthetic pathways of some plant and microbial GLA have been deciphered, current understanding of the correlation between ...
Yao Zhang, Xiao Luan, Huaiyuan Zhang, Victoriano Garre, Yuanda Song, Colin Ratledge   +5 more
doaj   +1 more source

An Approach to Heterologous Expression of Membrane Proteins. The Case of Bacteriorhodopsin. [PDF]

PLoS ONE, 2015
Heterologous overexpression of functional membrane proteins is a major bottleneck of structural biology. Bacteriorhodopsin from Halobium salinarum (bR) is a striking example of the difficulties in membrane protein overexpression.
Dmitry Bratanov, Taras Balandin, Ekaterina Round, Vitaly Shevchenko, Ivan Gushchin, Vitaly Polovinkin, Valentin Borshchevskiy, Valentin Gordeliy   +7 more
doaj   +1 more source

Overexpression of PRE1 and its Homologous Genes Activates Gibberellin-dependent Responses in Arabidopsis thaliana [PDF]

Plant and Cell Physiology, 2006
Gibberellins control various aspects of growth and development. Here, we identified a gene, designated paclobutrazol resistance1 (PRE1), by screening Arabidopsis activation-tagged lines. PRE1 encodes a helix-loop-helix protein and belongs to a small gene family.
Sumin, Lee, Seunghee, Lee, Ki-Young, Yang, Young-Mi, Kim, So-Yeon, Park, Soo Young, Kim, Moon-Soo, Soh   +6 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source