Results 31 to 40 of about 147,193 (248)

Genetic Modification of KNAT7 Transcription Factor Expression Enhances Saccharification and Reduces Recalcitrance of Woody Biomass in Poplars

Frontiers in Plant Science, 2021
The precise role of KNAT7 transcription factors (TFs) in regulating secondary cell wall (SCW) biosynthesis in poplars has remained unknown, while our understanding of KNAT7 functions in other plants is continuously evolving.
Yogesh Kumar Ahlawat, Yogesh Kumar Ahlawat, Akula Nookaraju, Anne E. Harman-Ware, Crissa Doeppke, Ajaya K. Biswal, Ajaya K. Biswal, Chandrashekhar P. Joshi   +7 more
doaj   +1 more source

A Human Homolog of Yeast Est1 Associates with Telomerase and Uncaps Chromosome Ends When Overexpressed [PDF]

Current Biology, 2003
Telomeres protect the eukaryotic chromosome ends from degradation and fusion. They are maintained by the ribonucleoprotein telomerase, the core of which is composed of a reverse transcriptase (TERT) and a RNA subunit. In the yeast Saccharomyces cerevisiae, a third critical telomerase subunit, the Ever Shorter Telomeres 1 (EST1) gene product, recruits ...
Reichenbach, P., Hoss, M., Azzalin, C. M., Nabholz, M., Bucher, P., Lingner, J.   +5 more
openaire   +3 more sources

Overexpression of tripartite motif-containing 47 (TRIM47) confers sensitivity to PARP inhibition via ubiquitylation of BRCA1 in triple negative breast cancer cells

Oncogenesis, 2023
Triple-negative breast cancers (TNBC) frequently harbor defects in DNA double-strand break repair through homologous recombination (HR), such as BRCA1 dysfunction.
Fengen Liu, Binhui Xie, Rong Ye, Yuankang Xie, Baiyin Zhong, Jinrong Zhu, Yao Tang, Zelong Lin, Huiru Tang, Ziqing Wu, Heping Li   +10 more
doaj   +1 more source

Phosphatase and Tension Homolog Overexpression in Insulin Resistant Diabetic Adipose Tissue

Chinese Medical Sciences Journal, 2014
To investigate the expression of phosphatase and tension homolog (PTEN) in adipose tissue of KKAy diabetic mice, a mouse model of type 2 diabetes.KKAy diabetic mice were fed with high fat diet for 4 weeks. After blood glucose met the criteria of diabetes (over 16.7 mmol/L), mice were randomly divided into 3 groups: a control group (without any ...
Jing-bo, Zeng, Yun, Zhang, Qi, Sun, Yu-xiu, Li   +3 more
openaire   +2 more sources

DNA polymerase   overexpression stimulates the Rad51-dependent homologous recombination in mammalian cells [PDF]

Nucleic Acids Research, 2004
Overexpression of DNA polymerase beta (polbeta), an error-prone DNA repair enzyme, has been shown to result in mutagenesis, aneuploidy and tumorigenesis. To further investigate the molecular basis leading to cancer-associated genetic changes, we examined whether the DNA polbeta could affect homologous recombination (HR).
Yvan, Canitrot, Jean-Pascal, Capp, Nadine, Puget, Anne, Bieth, Bernard, Lopez, Jean-Sébastien, Hoffmann, Christophe, Cazaux   +6 more
openaire   +2 more sources

Fusing an exonuclease with Cas9 enhances homologous recombination in Pichia pastoris

Microbial Cell Factories, 2022
Background The methylotrophic yeast Pichia pastoris is considered as an ideal host for the production of recombinant proteins and chemicals. However, low homologous recombination (HR) efficiency hinders its precise and extensive genetic manipulation.
Kun Zhang, Xingpeng Duan, Peng Cai, Linhui Gao, Xiaoyan Wu, Lun Yao, Yongjin J. Zhou   +6 more
doaj   +1 more source

Hsa-miR-155-5p Up-Regulation in Breast Cancer and Its Relevance for Treatment With Poly[ADP-Ribose] Polymerase 1 (PARP-1) Inhibitors

Frontiers in Oncology, 2020
miR-155-5p is a well-known oncogenic microRNA, showing frequent overexpression in human malignancies, including breast cancer. Here, we show that high miR-155-5p levels are associated with unfavorable prognostic factors in two independent breast cancer ...
Barbara Pasculli, Raffaela Barbano, Andrea Fontana, Tommaso Biagini, Maria Pia Di Viesti, Michelina Rendina, Vanna Maria Valori, Maria Morritti, Sara Bravaccini, Sara Ravaioli, Evaristo Maiello, Paolo Graziano, Roberto Murgo, Massimiliano Copetti, Tommaso Mazza, Vito Michele Fazio, Manel Esteller, Manel Esteller, Manel Esteller, Manel Esteller, Paola Parrella   +20 more
doaj   +1 more source

Genome-Wide Analysis of the Soybean TIFY Family and Identification of GmTIFY10e and GmTIFY10g Response to Salt Stress

Frontiers in Plant Science, 2022
TIFY proteins play crucial roles in plant abiotic and biotic stress responses. Our transcriptome data revealed several TIFY family genes with significantly upregulated expression under drought, salt, and ABA treatments.
Ya-Li Liu, Ya-Li Liu, Lei Zheng, Long-Guo Jin, Yuan-Xia Liu, Ya-Nan Kong, Yi-Xuan Wang, Tai-Fei Yu, Jun Chen, Yong-Bin Zhou, Ming Chen, Feng-Zhi Wang, You-Zhi Ma, Zhao-Shi Xu, Jin-Hao Lan   +14 more
doaj   +1 more source

Homologous Overexpression of Genes in Cordyceps militaris Improves the Production of Polysaccharide

, 2020
Abstract Background Cordyceps polysaccharides have been used around the globe for its bioactivity for millennia. However, the study and medicinal of Cordyceps militaris polysaccharides has been hampered by the low in natural abundances. Recently, the genetic engineered C.
Xi Yang, Yifeng Wang, Ping Chen, Linglu Fan, Shengli Yang, Hui Zhang   +5 more
openaire   +1 more source

Overexpression of a Rice NPR1 Homolog Leads to Constitutive Activation of Defense Response and Hypersensitivity to Light [PDF]

Molecular Plant-Microbe Interactions®, 2005
Arabidopsis NPR1/NIM1 is a key regulator of systemic acquired resistance (SAR), which confers lasting broad-spectrum resistance. Previous reports indicate that rice has a disease-resistance pathway similar to the Arabidopsis SAR pathway. Here we report the isolation and characterization of a rice NPR1 homologue (NH1).
Chern, Mawsheng, Fitzgerald, Heather A, Canlas, Patrick E, Navarre, Duroy A, Ronald, Pamela C   +4 more
openaire   +4 more sources