Results 21 to 30 of about 147,193 (248)

Characterization of NAD+/NADP+-Specific Isocitrate Dehydrogenases From Oleaginous Fungus Mortierella alpina Involved in Lipid Accumulation

Frontiers in Nutrition, 2021
Mortierella alpina has a strong capacity for lipid accumulation. Isocitrate dehydrogenase (IDH) plays an important role in affecting the flow of intracellular carbon sources and reducing power NADPH for lipid biosynthesis.
Xin Tang, Xin Tang, Xiaoqi Sun, Xiaoqi Sun, Xuxu Wang, Xuxu Wang, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang, Yong Q. Chen, Yong Q. Chen, Yong Q. Chen, Yong Q. Chen, Jianxin Zhao, Jianxin Zhao, Haiqin Chen, Haiqin Chen, Wei Chen, Wei Chen, Wei Chen, Wei Chen   +21 more
doaj   +1 more source

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors [PDF]

Cell, 2019
Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 deficiency leads to increased sensitivity to genotoxic stress and delayed DNA double-strand break (DSB) repair.
Jachimowicz, R. D., Beleggia, F., Isensee, J., Velpula, B. B., Goergens, J., Bustos, M. A., Doll, M. A., Shenoy, A., Checa-Rodriguez, C., Wiederstein, J. L., Baranes-Bachar, K., Bartenhagen, C., Hertwig, F., Teper, N., Nishi, T., Schmitt, A., Distelmaier, F., Lüdecke, Hermann-Josef, Albrecht, Beate, Krüger, M., Schumacher, B., Geiger, T., Hoon, D. S. B., Huertas, P., Fischer, M., Hucho, T., Peifer, M., Ziv, Y., Reinhardt, Hans Christian, Wieczorek, Dagmar, Shiloh, Y.   +30 more
openaire   +6 more sources

Maize BIG GRAIN1 homolog overexpression increases maize grain yield [PDF]

Plant Biotechnology Journal, 2020
SummaryThe Zea Mays BIG GRAIN 1 HOMOLOG 1 (ZM‐BG1H1) was ectopically expressed in maize. Elite commercial hybrid germplasm was yield tested in diverse field environment locations representing commercial models. Yield was measured in 101 tests across all 4 events, 26 locations over 2 years, for an average yield gain of 355 kg/ha (5.65 bu/ac) above ...
Carl R. Simmons, Benjamin P. Weers, Kellie S. Reimann, Shane E. Abbitt, Mary J. Frank, Wuyi Wang, Jingrui Wu, Bo Shen, Jeffrey E. Habben   +8 more
openaire   +2 more sources

Simultaneous overexpression of ∆6-, ∆12- and ∆9-desaturases enhanced the production of γ-linolenic acid in Mucor circinelloides WJ11

Frontiers in Microbiology, 2022
Mucor circinelloides WJ11, an oleaginous filamentous fungus, produces 36% lipid of its cell dry weight when cultured in a high C/N ratio medium, however, the yield of γ-linolenic acid (GLA) is insufficient to make it competitive with other plant sources.
Xiuwen Wang, Junhuan Yang, Hassan Mohamed, Hassan Mohamed, Aabid Manzoor Shah, Shaoqi Li, Shuxian Pang, Chen Wu, Futing Xue, Wenyue Shi, Beenish Sadaqat, Yuanda Song   +11 more
doaj   +1 more source

Applications of Diacylglycerol Acyltransferase for Triacylglycerol Production in Mortierella alpina

Journal of Fungi, 2023
Triacylglycerol (TG) with high-value long-chain polyunsaturated fatty acids is beneficial to human health; consequently, there is an urgent need to broaden its sources due to the current growing demand.
Ruilin Yu, Lulu Chang, Jun Cao, Bo Yang, Haiqin Chen, Wei Chen   +5 more
doaj   +1 more source

Generation of a transgenic mouse embryonic stem cell line overexpressing DNMT1

Stem Cell Research, 2023
DNMT1 overexpression is reported in disorders like schizophrenia, bipolar, epilepsy and multiple cancer types. Here, we used non-homologous recombination to generate R1Dnmt1WT-1, a mouse embryonic stem cell (ESC) line carrying a Dnmt1 cDNA transgene to ...
Sumana Choudhury, Anuhya Anne, Purnima P. Pradhan, K. Naga Mohan   +3 more
doaj   +1 more source

Overexpression of homologous phytochrome genes in tomato: exploring the limits in photoperception [PDF]

Journal of Experimental Botany, 2007
Transgenic tomato [Lycopersicon esculentum (=Solanum lycopersicum)] lines overexpressing tomato PHYA, PHYB1, or PHYB2, under control of the constitutive double-35S promoter from cauliflower mosaic virus (CaMV) have been generated to test the level of saturation in individual phytochrome-signalling pathways in tomato. Western blot analysis confirmed the
Said S H, Husaineid, Rosan A, Kok, Marielle E L, Schreuder, Mamatha, Hanumappa, Marie-Michèle, Cordonnier-Pratt, Lee H, Pratt, Linus H W, van der Plas, Alexander R, van der Krol   +7 more
openaire   +3 more sources

Shugoshin1 may play important roles in separation of homologous chromosomes and sister chromatids during mouse oocyte meiosis. [PDF]

PLoS ONE, 2008
BACKGROUND: Homologous chromosomes separate in meiosis I and sister chromatids separate in meiosis II, generating haploid gametes. To address the question why sister chromatids do not separate in meiosis I, we explored the roles of Shogoshin1 (Sgo1) in ...
Shen Yin, Jun-Shu Ai, Li-Hong Shi, Liang Wei, Ju Yuan, Ying-Chun Ouyang, Yi Hou, Da-Yuan Chen, Heide Schatten, Qing-Yuan Sun   +9 more
doaj   +1 more source

Recombination machinery engineering for precise genome editing in methylotrophic yeast Ogataea polymorpha

iScience, 2021
Summary: Methanol biotransformation can expand biorefinery substrate spectrum other than biomass by using methylotrophic microbes. Ogataea (Hansenula) polymorpha, a representative methylotrophic yeast, attracts much attention due to its thermotolerance ...
Jiaoqi Gao, Ning Gao, Xiaoxin Zhai, Yongjin J. Zhou   +3 more
doaj   +1 more source

Construction of DGLA producing cell factory by genetic modification of Mucor circinelloides

Microbial Cell Factories, 2019
Background Dihomo-gamma linolenic acid (DGLA, 20:3, n-6) is the elongated product of Gamma linolenic acid (GLA, 18:3, n-6) catalyzed by the enzyme delta-6 elongase (D6E) or gamma linolenic acid elongase (GLELO).
Md. Ahsanul Kabir Khan, Junhuan Yang, Syed Ammar Hussain, Huaiyuan Zhang, Li Liang, Victoriano Garre, Yuanda Song   +6 more
doaj   +1 more source