Results 1 to 10 of about 147,193 (248)

A homologous overexpression system to study roles of drug transporters in Candida glabrata. [PDF]

FEMS Yeast Res, 2020
Abstract Considering the relevance of drug transporters belonging to ABC and MFS superfamilies in pathogenic Candida species, there has always been a need to have an overexpression system where these membrane proteins for functional analysis could be expressed in a homologous background. We could address this unmet need by constructing a
Kumari S, Kumar M, Khandelwal NK, Pandey AK, Bhakt P, Kaur R, Prasad R, Gaur NA.   +7 more
europepmc   +4 more sources

Low expression of miR-7-5p promotes resistance to radiotherapy in lung cancer through direct upregulation of PKP2 expression

Scientific Reports
Lung cancer remains a significant global health challenge, with advanced stages often limiting surgical options and necessitating systemic therapies, such as radiotherapy. Resistance to radiotherapy frequently undermines the treatment efficacy.
Fan Zhang, Jiaxue Yang, Xiao-lu Qiu, Jie He, Chun Cheng, Yi Sang   +5 more
doaj   +1 more source

Increased Expression of AbcA Efflux Pump Accelerated Resistance Development from Tolerance to Resistance Against Oxacillin in Staphylococcus aureus

Microorganisms
Bacterial tolerance, especially in Staphylococcus aureus (S. aureus), may arise under intermittent antibiotic regimens and act as a stepping stone toward resistance development.
Xiaohui Yu, Miaomiao Liu, Pilong Liu, Zehua Hao, Lili Zhao, Xin Zhao   +5 more
doaj   +1 more source

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

Cell Reports, 2015
Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and mediate its repair.
Alkmini Kalousi, Anne-Sophie Hoffbeck, Platonas N. Selemenakis, Jordan Pinder, Kienan I. Savage, Kum Kum Khanna, Laurent Brino, Graham Dellaire, Vassilis G. Gorgoulis, Evi Soutoglou   +9 more
doaj   +1 more source

PtoHsfB1 regulates growth and salt response by affecting ABA biosynthesis in Populus tomentosa

Forestry Research
Poplar is an important commercial timber species and a model organism for forest molecular biology. Here, we identified PtoHsfB1, a subgroup B heat shock transcription factor from Populus tomentosa that is homologous to AtHsfB1 and PtrHsfB1, and contains
Kunjin Han, Huayu Si, Ye Li, Jifeng Yan, Yousry A. El-Kassaby, Yizhe Cheng, Houyin Deng, Jie Liu, Yuhan Sun, Yun Li, Ye Zhao   +10 more
doaj   +1 more source

PBX1 attenuates MeHg-induced apoptosis by reducing ROS accumulation, mitigating double-strand DNA breaks, and enhancing homologous recombination DNA repair in SH-SY5Y cells

Ecotoxicology and Environmental Safety
Methylmercury (MeHg), a highly neurotoxic organic heavy metal, penetrates the central nervous system to induce oxidative damage and DNA double-strand breaks (DSBs).
Kuiyang Zuo, Ziyi Chen, Rifeng Lu, Xiaomei Liu, Jinyu Liu   +4 more
doaj   +1 more source

Optimizing the CRISPR/Cas9 system for gene editing in Yarrowia lipolytica

Engineering Microbiology
Yarrowia lipolytica is a promising host for producing valuable chemicals owing to its robustness and metabolic versatility. Efficient genome editing tools are essential for advancing its biotechnological applications.
Jianhui Liu, Yamin Zhu, Jin Hou
doaj   +1 more source

Effect of CDX2 on proliferation, invasion, migration, and apoptosis of duodenal cancer cells

European Journal of Histochemistry
This study investigates the expression and biological role of caudal homologous transcription factor 2 (CDX2) in duodenal carcinoma. Paraffin-embedded samples from 40 duodenal carcinoma cases were analyzed using immunohistochemistry on a tissue ...
Jun Pan, Yi Zhao, Yu Zhang, Yuhe Zhou, Fengxuan Zhang, Yitian Chen, Xiaoyuan Chu   +6 more
doaj   +1 more source

Improving the production of baculovirus expression vector by overexpression of IE0/IE1 through tandem promoter.

PLoS ONE
The baculovirus expression vector system, known for its protein production in insect cells and has been criticized for its relatively low expression capacity.
Sijun He, Weining Li, Ruirui Zhang, Hao Nan, Wangcheng Song, Xiaodong Xu   +5 more
doaj   +1 more source

The miR166–ATHB14-LIKE module regulates flavonoid biosynthesis in soybean

Crop Journal
Flavonoids are crucial secondary metabolites widely distributed in plants, playing vital roles in diverse biological processes. Although the flavonoid biosynthesis pathway has been extensively characterized, the transcriptional regulatory mechanisms ...
Chen Yan, Jiaxin Zhang, Ye Zhang, Chen Zhao, Jingjing Ma, Yaohua Zhang, Suxin Yang, Xianzhong Feng, Jun Yan   +8 more
doaj   +1 more source