Results 171 to 180 of about 651,783 (359)

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Homologous recombination [PDF]

Current Biology, 2000
openaire   +2 more sources

Compound Heterozygous Variants in ZSWIM7 Gene Linked to Infertility and Its Role in Gonadal Development

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT This study aims to elucidate the role of the ZSWIM7 gene in the etiology of infertility, focusing on its potential association with premature ovarian insufficiency and azoospermia. We investigated an 18‐year‐old female patient who presented with primary amenorrhea, hypoplasia of the uterus and ovaries, Tanner stage II breast and pubic hair ...
Denise M. Christofolini, Guilherme Pinn, Thainá Vilella, Maria I. Melaragno, Mariana Moysés‐Oliveira, Luciano Pompei, Rare Genomes Project Consortium, Bianca Bianco, Caio P. Barbosa   +8 more
wiley   +1 more source

Clinical, splicing, and functional analysis to classify BRCA2 exon 3 variants: Application of a points‐based ACMG/AMP approach

Human Mutation, Volume 43, Issue 12, Page 1921-1944, December 2022., 2022
Abstract Skipping of BRCA2 exon 3 (∆E3) is a naturally occurring splicing event, complicating clinical classification of variants that may alter ∆E3 expression. This study used multiple evidence types to assess pathogenicity of 85 variants in/near BRCA2 exon 3.
Mads Thomassen, Romy L. S. Mesman, Thomas V. O. Hansen, Mireia Menendez, Maria Rossing, Ada Esteban‐Sánchez, Emma Tudini, Therese Törngren, Michael T. Parsons, Inge S. Pedersen, Soo H. Teo, Torben A. Kruse, Pål Møller, Åke Borg, Uffe B. Jensen, Lise L. Christensen, Christian F. Singer, Daniela Muhr, Marta Santamarina, Rita Brandao, Brage S. Andresen, Bing‐Jian Feng, Daffodil Canson, Marcy E. Richardson, Rachid Karam, Tina Pesaran, Holly LaDuca, Blair R. Conner, Nelly Abualkheir, Lily Hoang, Fabienne M. G. R. Calléja, Lesley Andrews, Paul A. James, Dave Bunyan, Amanda Hamblett, Paolo Radice, David E. Goldgar, Logan C. Walker, Christoph Engel, Kathleen B. M. Claes, Eva Macháčková, Diana Baralle, Alessandra Viel, Barbara Wappenschmidt, Conxi Lazaro, Ana Vega, ENIGMA Consortium, Maaike P. G. Vreeswijk, Miguel de la Hoya, Amanda B. Spurdle   +49 more
wiley   +1 more source

Homologous recombination can restore normal immunoglobulin production in a mutant hybridoma cell line. [PDF]

, 1988
Mark D. Baker, Nancy Pennell, Lucine Bosnoyan, Marc J. Shulman   +3 more
openalex   +1 more source

Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer

International Journal of Cancer, Volume 152, Issue 5, Page 945-951, 1 March 2023., 2023
What's new? Intrapatient tumor heterogeneity and clonal evolution of primary tumor foci into metastatic disease remain significant challenges for prostate cancer treatment. Here, investigating metastatic lesion origins, the authors compared somatic mutations in spatially distinct primary foci to mutations in recurring disease in seven prostate cancer ...
Kristina T. Carm, Bjarne Johannessen, Mari Bogaard, Anne Cathrine Bakken, Aase V. Maltau, Andreas M. Hoff, Ulrika Axcrona, Karol Axcrona, Ragnhild A. Lothe, Rolf I. Skotheim   +9 more
wiley   +1 more source

Effect of double-strand breaks on homologous recombination in mammalian cells and extracts. [PDF]

, 1985
K Y Song, Lavanya Chekuri, Sikha Rauth, S. Dusko Ehrlich, Raju Kucherlapati   +4 more
openalex   +1 more source

Survival outcomes of metastatic breast cancer patients by germline BRCA1/2 status in a large multicenter real‐world database

International Journal of Cancer, Volume 152, Issue 5, Page 921-931, 1 March 2023., 2023
What's new? Despite the recent approval of novel therapeutics for germline BRCA1/2‐mutated metastatic breast cancer, data regarding outcomes and optimal treatment strategies are lacking. This study assessed the impact of germline BRCA mutations on metastatic breast cancer survival using data from a cohort of patients treated in an era predating PARP ...
Audrey Mailliez, Veronique D'Hondt, Amelie Lusque, Olivier Caron, Luc Cabel, Anthony Goncalves, Marc Debled, Laurence Gladieff, Jean‐Marc Ferrero, Thierry Petit, Marie Ange Mouret‐Reynier, Jean‐Christophe Eymard, Christelle Levy, Lionel Uwer, Marianne Leheurteur, Isabelle Desmoulins, Thomas Bachelot, Jean‐Sebastien Frenel, Thibault de la Motte Rouge, Gaëtane Simon, William Jacot, Suzette Delaloge   +21 more
wiley   +1 more source

Competition between One‐ and Two‐Electron Unimolecular Reactions of Late 3d‐Metal Complexes [(Me3SiCH2)nM]–(M = Fe, Co, Ni, and Cu; n = 2–4)

Angewandte Chemie International Edition, EarlyView.
Gas‐phase fragmentation experiments and theoretical calculations on a series of model complexes determine the intrinsic tendencies of the late 3d metals to undergo one‐versus two‐electron reactions and unravel the factors controlling the selectivity. Abstract Although organometallic complexes of the late 3d elements are known to undergo both one‐and ...
Torben Kühl, Lisa Hetzel, Christopher J. Stein, Konrad Koszinowski   +3 more
wiley   +1 more source

Homologous recombination of SV4O DNA in COS7 cells occurs with high frequency m a gene dose independent fashion [PDF]

, 1988
W Rommerskirch, Ingeborg Graeber, M. Grässmann, Adolf Grássmann   +3 more
openalex   +1 more source