Results 191 to 200 of about 766,679 (374)

Comparative analysis of two newly established Cre rat lines, NeuN‐Cre and Thy1‐Cre, for neurological research

Animal Models and Experimental Medicine, EarlyView.
We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li, Chenyang Liu, Gefan Wan, Lei Zhang, Rui Fan, Xu Zhang, Yuanlong Su, Jiayue He, Ning Liu, Feifei Guan, Wei Dong, Shan Gao, Weining Kong, Xiaolong Qi, Xiaolin Zhang, Yuanwu Ma   +15 more
wiley   +1 more source

Homologous recombination between transferred and chromosomal immunoglobulin kappa genes. [PDF]

, 1988
Mark D. Baker, Marc J. Shulman
openalex   +1 more source

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer

Clinical Cancer Research, 2016
M. Telli, K. Timms, J. Reid, B. Hennessy, G. Mills, K. Jensen, Z. Szallasi, W. Barry, E. Winer, N. Tung, S. Isakoff, P. Ryan, April Greene-Colozzi, A. Gutin, Zaina Sangale, D. Iliev, C. Neff, V. Abkevich, Joshua T. Jones, J. Lanchbury, A. Hartman, J. Garber, J. Ford, D. Silver, A. Richardson   +24 more
semanticscholar   +1 more source

Advances on Albumin‐Based Carriers for Anticancer Drug Delivery

Advanced NanoBiomed Research, EarlyView.
This study systematically classifies the drug delivery modes of albumin by examining the characteristics of its surface‐active groups and internal binding sites. It provides an in‐depth analysis of various drug delivery strategies and their corresponding targeting mechanisms.
Ruoli Zhou, Rongbin Zhong, Zhonghui Luo, Hua Wei, Cui‐Yun Yu   +4 more
wiley   +1 more source

Sensitive homologous recombination strand-transfer assay: partial purification of a Drosophila melanogaster enzyme and detection of sequence effects on the strand-transfer activity of RecA protein.

, 1988
James McCarthy, M Sander, Ky Lowenhaupt, Alexander Rich   +3 more
openalex   +1 more source

recE4 -Independent Recombination Between Homologous Deoxyribonucleic Acid Segments of Bacillus subtilis Plasmids [PDF]

, 1980

openalex   +1 more source

Enhanced Production of Astaxanthin and Zeaxanthin by Paracoccus Sp. LL1 Through Random Mutagenesis

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Astaxanthin, a high‐value carotenoid with potent antioxidant and anti‐inflammatory activities, is increasingly in demand in various industries. This study reports the successful enhancement of astaxanthin and zeaxanthin production in Paracoccus sp. LL1 through random mutagenesis using ethyl methanesulfonate (EMS).
Anoth Maharjan, Beom Soo Kim
wiley   +1 more source

Mutations and homologous recombination induced in mammalian cells by metabolites of benzo[a]pyrene and 1-nitropyrene.

, 1987
Vincent Maher, J D Patton, Jia‐Ling Yang, Y Y Wang, Li Yang, A.E. Aust, Nitai P. Bhattacharyya, J J McCormick   +7 more
openalex   +1 more source

Production of mouse V/human C chimeric kappa genes by homologous recombination in hybridoma cells. Analysis of vector design and recombinant gene expression. [PDF]

, 1994
Weili Sun, Ji Xiong, Marc J. Shulman
openalex   +1 more source

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source