Positive genetic selection for gene disruption in mammalian cells by homologous recombination.
, 1989 John M. Sedivy, Phillip A. Sharp
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recE4 -Independent Recombination Between Homologous Deoxyribonucleic Acid Segments of Bacillus subtilis Plasmids [PDF]
, 1980 openalex +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Protein developability is an important, yet often overlooked, aspect of protein discovery campaigns that is a key driver of utility. Recent advances have improved developability screening capacity, making it an increasingly viable option in early‐stage discovery.
Gregory H. Nielsen +2 more
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Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis
iMeta, Volume 1, Issue 4, December 2022., 2022 Intestinal stem cells (ISCs) are protected by their niche and are regulated by Wnt, bone morphogenetic protein, and Notch. ISCs and their relationship with intestinal microbiota provide a feasible pathway to alleviate intestinal diseases. Diverse bacteria‐related postbiotics regulate ISCs and maintain their homeostasis.
Ning Ma +3 more
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Production of mouse V/human C chimeric kappa genes by homologous recombination in hybridoma cells. Analysis of vector design and recombinant gene expression. [PDF]
, 1994 Weili Sun, Ji Xiong, Marc J. Shulman
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Engineering antibodies with cancer‐associated binding sites
BMEMat, EarlyView.This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian +4 more
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Over two decades of research on the marine RNA virosphere
iMeta, Volume 1, Issue 4, December 2022., 2022 Advances in meta‐omics provide a surge of marine RNA virus information. Deep marine virus discovery contributes greatly to the megataxonomy of RNA viruses. Understanding diversity and biogeography helps reveal the significance of marine RNA viruses, including evolutionary trajectories, hierarchical taxonomy, and ecological importance.
Meng‐en Liao +3 more
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A mitochondrial retroplasmid integrates into mitochondrial DNA by a novel mechanism involving the synthesis of a hybrid cDNA and homologous recombination. [PDF]
, 1994 Chia-Chien Chiang +3 more
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Pan‐cancer analysis shapes the understanding of cancer biology and medicine
Cancer Communications, EarlyView.Abstract Advances in multi‐omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan‐cancer perspective. Pan‐cancer studies identify shared mechanisms and unique traits across different cancer types, which are reshaping diagnostic and treatment strategies.
Xiaoping Cen +21 more
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Nucleic acid nanostructure for delivery of CRISPR/Cas9‐based gene editing system
Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023 Multifunctional nucleic acid nanostructures, including RCA‐derived DNA, branched DNA, and hybrid DNA, have been developed for delivery of CRISPR/Cas9‐based gene editing system for gene therapy. Abstract CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR‐associated protein 9)‐based gene editing system has aroused great ...
Wantao Tang, Jianbing Liu, Baoquan Ding
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