Results 191 to 200 of about 789,870 (314)

PEK14: A Kinesin‐4 Necessary for Male‐Derived Fertility in Arabidopsis thaliana

Cytoskeleton, EarlyView.
ABSTRACT Of the 61 kinesins annotated in Arabidopsis thaliana, many are still without assigned function. Here, we have screened an insertional mutant library of Arabidopsis pollen‐expressed kinesins for fertility defects. Insertional mutants for three kinesins showed a significant reduction in seed set.
Isabella N. Mendes, Norman R. Groves, Jessica Z. Li, Lily N. Thompson, Brian J. Smith, Aman Y. Husbands, Iris Meier   +6 more
wiley   +1 more source

Mutation patterns and prognostic potentiality of homologous recombination repair genes in gliomas. [PDF]

BMC Cancer
Bai H, Liu Y, Ji C, Zhang Q, Luo N, Zhang X, Zheng Z.   +6 more
europepmc   +1 more source

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Homologous Recombination Deficiency in Skin Cancers: Prevalence and Clinical Implications of This Distinct Patient Cohort. [PDF]

JCO Precis Oncol
Nassief G, Adeyelu T, Elliott A, Phillipps J, Morecroft R, Zhou AY, Szlosarek PW, Robert C, Abdulla F, Vanderwalde A, Park SJ, Chen D, Ansstas G.   +12 more
europepmc   +1 more source

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

Cell, 2019
R. Jachimowicz, Filippo Beleggia, Jörg Isensee, Bhagya Bhavana Velpula, J. Goergens, Matias A. Bustos, Markus A. Doll, Anjana Shenoy, Cintia Checa-Rodríguez, J. Wiederstein, Keren Baranes-Bachar, C. Bartenhagen, F. Hertwig, Nizan Teper, Tomohiko Nishi, A. Schmitt, F. Distelmaier, H. Lüdecke, B. Albrecht, M. Krüger, B. Schumacher, T. Geiger, Dave S.B. Hoon, Pablo Huertas, M. Fischer, T. Hucho, M. Peifer, Y. Ziv, H. Christian Reinhardt, D. Wieczorek, Y. Shiloh   +30 more
semanticscholar   +1 more source

In Vivo Cytoskeletal AMPA Receptor Transport Imaging in C. elegans

Cytoskeleton, EarlyView.
ABSTRACT Long‐distance intracellular transport of ionotropic glutamate receptors (iGluRs) is essential for proper excitatory synaptic function underlying learning and memory. Many neuropsychiatric and neurodegenerative conditions have abnormal iGluR transport and trafficking, leading to an intense interest in the mechanisms and factors regulating these
Michaelis A. K., Hoerndli F. J.
wiley   +1 more source

Whole genome sequencing approach to assess homologous recombination deficiency in a pan-cancer cohort. [PDF]

Commun Med (Lond)
Al Assaad M, Hadi K, Levine MF, Guevara D, Patel M, Tranquille M, King A, Otilano J, Semaan A, Gundem G, Medina-Martínez JS, Sigouros M, Manohar J, Kuo HH, Wilkes DC, Andreopoulou E, Chapman-Davis E, Tagawa ST, Sboner A, Ocean AJ, Shah MA, Papaemmanuil E, Sternberg CN, Holcomb K, Nanus DM, Elemento O, Mosquera JM.   +26 more
europepmc   +1 more source

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Lack of synergy between AR-targeted therapies and PARP inhibitors in homologous recombination-proficient prostate cancer. [PDF]

Proc Natl Acad Sci U S A
Traphagen NA, Wheeler E, Li R, Akhshi T, Ravindranathan R, Alfieri C, Lu F, Ahmed B, Tewari AK, Balk SP, Nelson PS, Corey E, Long H, D'Andrea AD, Qiu X, Brown M.   +15 more
europepmc   +1 more source

Repression of BET activity sensitizes homologous recombination–proficient cancers to PARP inhibition

Science Translational Medicine, 2017
Lu Yang, Youyou Zhang, Weiwei Shan, Zhongyi Hu, Jiao Yuan, Jingjiang Pi, Yueying Wang, L. Fan, Zhaoqing Tang, Chunsheng Li, Xiaowen Hu, J. Tanyi, Yi Fan, Qihong Huang, K. Montone, C. Dang, Lin Zhang   +16 more
semanticscholar   +1 more source