Results 191 to 200 of about 773,827 (377)

UHRF1 Controls the Timing of RAD51 Removal During DNA Damage Repair Through Suppressing RFWD3

Advanced Science, EarlyView.
We demonstrate here that the recombinase RAD51 is protected by UHRF1 through ubiquitinating RFWD3, an E3 for RAD51, and this very process is inhibited by RAD51, leading to a triple negative feedback circuit that ensures appropriate levels of RFWD3 and RAD51 for DNA damage response. Abstract The RAD51 recombinase is evolutionarily conserved critical for
Guangxue Liu, Kaiyan Huang, Shiyao Liu, Ziyu Sheng, Pumin Zhang   +4 more
wiley   +1 more source

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer

Clinical Cancer Research, 2016
M. Telli, K. Timms, J. Reid, B. Hennessy, G. Mills, K. Jensen, Z. Szallasi, W. Barry, E. Winer, N. Tung, S. Isakoff, P. Ryan, April Greene-Colozzi, A. Gutin, Zaina Sangale, D. Iliev, C. Neff, V. Abkevich, Joshua T. Jones, J. Lanchbury, A. Hartman, J. Garber, J. Ford, D. Silver, A. Richardson   +24 more
semanticscholar   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

Advanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou, Ruibing Deng, Zunde Liao, Xiaoyu Huang, Junting Huang, Hanlou Yang, Kam W. Leong, Yiling Zhong   +7 more
wiley   +1 more source

recE4 -Independent Recombination Between Homologous Deoxyribonucleic Acid Segments of Bacillus subtilis Plasmids [PDF]

, 1980

openalex   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

Strong Internal Electric Field‐Driven S‐scheme CoAl‐LDH/ZrO2 Heterojunction for Enhanced Photocatalytic CO2 Reduction: Configuration, Performance, and Mechanism

Advanced Science, EarlyView.
This study constructed an S‐scheme heterojunction catalyst CoAl‐LDH/ZrO2 driven by an internal electric field. The S‐scheme heterojunction accelerated charge separation and strengthened redox capability synergistically contribute to the superior CO2 reduction performance.Under simulated solar irradiation, optimal catalyst exhibited a CO production rate
Mengwei Chen, Jiaze Xiao, Yongxin Lei, Xupeng Qin, Santosh K. Tiwari, Nannan Wang, Zhiyao Wu, Yanqiu Zhu, Xinpeng Wang   +8 more
wiley   +1 more source

Extrachromosomal homologous DNA recombination in plant cells is fast and is not affected by CpG methylation. [PDF]

, 1992
Holger Puchta, Serge Kocher, Barbara Höhn   +2 more
openalex   +1 more source

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

Advanced Science, EarlyView.
An intelligent lactate‐depleting LOCoF2 (CoF2@LOx) nanoreactor system is developed to effectively induce self‐reinforced pyroptosis and activate the cGAS‐STING signaling pathway, thereby inducing a strong immune response and enhancing the therapeutic effectiveness of catalytic immunotherapy.
Linzhu Zhang, Shumin Sun, Duo Wang, Nailin Yang, Di Wang, Jihu Nie, Zifan Pei, Juan Qin, Lei Zhang, Haidong Zhu, Liang Cheng   +10 more
wiley   +1 more source

Positive genetic selection for gene disruption in mammalian cells by homologous recombination.

, 1989
John M. Sedivy, Phillip A. Sharp
openalex   +1 more source

Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker [PDF]

, 1993
Marcelo Rubinstein, Miguel Á. Japón, Malcolm J. Low   +2 more
openalex   +1 more source