Results 191 to 200 of about 348,739 (321)

Defect-complementation homologous recombination: A novel strategy for precise genome engineering of virulent phages. [PDF]

Synth Syst Biotechnol
Zhang H, Song Y, Liu W, Zheng X, An X, Li C, Chen W, Wang H, Zhang Y.   +8 more
europepmc   +1 more source

A novel carcinogenic mouse model by site‐directed insertion of tandem human HRAS large DNA fragment into 15E1 site

Animal Models and Experimental Medicine, EarlyView.
The NF‐hHRAS mouse model was generated through Chr15 E1 locus‐targeted integration of a 21 kb multicopy HRAS gene cluster. The NF‐hHRAS model demostrated tissue‐specific expression of human HRAS across multiple organs and low spontaneous tumorigenesis.
Susu Liu, Yanwei Yang, Guitao Huo, Hao Yang Zhao, Chen Ling, YuYa Wang, Shijie Zhai, Xiaowei Sun, Wenda Gu, Yuan Cao, Wei Gong, Sanlong Wang, Changfa Fan   +12 more
wiley   +1 more source

Homologous Recombination Deficiency and Survival in Ovarian High-Grade Serous Carcinoma by Self-Reported Race. [PDF]

Cancer Epidemiol Biomarkers Prev
Lawson-Michod KA, Johnson CE, Barnard ME, Davidson NR, Collin LJ, Nix DA, Huff CD, Berchuck A, Salas LA, Greene CS, Marks JR, Peres LC, Doherty JA, Schildkraut JM.   +13 more
europepmc   +1 more source

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Supplementary Figure 1 from A Preclinical Trial and Molecularly Annotated Patient Cohort Identify Predictive Biomarkers in Homologous Recombination–deficient Pancreatic Cancer

, 2023
Yifan Wang, Jin Yong Patrick Park, Alain Pacis, Robert E. Denroche, Gun Ho Jang, Amy Zhang, Adeline Cuggia, Céline Domecq, Jean Monlong, Maria Raitses‐Gurevich, Robert C. Grant, Ayelet Borgida, Spring Holter, Chani Stossel, Simeng Bu, Mehdi Masoomian, Ilinca M. Lungu, John M.S. Bartlett, Julie M. Wilson, Zu‐Hua Gao, Yasser Riazalhosseini, Jamil Asselah, Nathaniel Bouganim, Tatiana Cabrera, Louis-Martin Boucher, David Valenti, James Biagi, Celia M.T. Greenwood, Paz Polak, William D. Foulkes, Talia Golan, Grainne M. O’Kane, Sandra E. Fischer, Jennifer J. Knox, Steven Gallinger, George Zogopoulos   +35 more
openalex   +1 more source

Substantial non-homologous recombination and structural variation results from Brassica AABC and CCAB hybrid meiosis. [PDF]

Plant J
Lv Z, Mahmoudi S, Mason AS.
europepmc   +1 more source

Homologous Recombination [PDF]

, 2019
openaire   +1 more source

RAD51-mediated homologous recombination is a pro-tumour driver pathway. [PDF]

Oncogene
Lopez BS.
europepmc   +1 more source

Correction: Neoadjuvant olaparib targets hypoxia to improve radioresponse in a homologous recombination-proficient breast cancer model

, 2020
Gerben R. Borst, Ramya Kumareswaran, Hatice Yücel, Seyda Telli, Trevor Do, Trevor D. McKee, Gaetano Zafarana, Jos Jonkers, Marcel Verheij, Mark J. O’Connor, Sven Rottenberg, Robert G. Bristow   +11 more
openalex   +1 more source

Production of mouse V/human C chimeric kappa genes by homologous recombination in hybridoma cells. Analysis of vector design and recombinant gene expression. [PDF]

, 1994
Weili Sun, Ji Xiong, Marc J. Shulman
openalex   +1 more source