Results 211 to 220 of about 769,180 (373)

Approaches to repurposing reverse transcriptase antivirals in cancer

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head   +2 more
wiley   +1 more source

Transcription‐Replication Conflicts: Unlocking New Frontiers in Cancer

open access: yesBioEssays, EarlyView.
Transcription‐replication conflicts (TRCs) constitute a major source of genome instability. Such conflicts are regulated by chromatin, its dysfunction causing replication stress, DNA breaks, and mutations frequently found in cancer. We review the molecular basis of TRCs and chromatin regulation and discuss the clinical potential of targeting TRCs as ...
Aleix Bayona‐Feliu, Andrés Aguilera
wiley   +1 more source

The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer. [PDF]

open access: yesOncologist
Jiang B   +10 more
europepmc   +1 more source

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

open access: yesNature Genetics, 2017
P. Polak   +27 more
semanticscholar   +1 more source

When numbers matter: Rethinking the role of gene duplication on short evolutionary timescales

open access: yes
American Journal of Botany, EarlyView.
Freja Lindstedt   +2 more
wiley   +1 more source

A Bioprocess Engineering Approach to Boost Selection of Fully Segregated Transformants in Cyanobacteria

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT Cyanobacteria are photoautotrophic microorganisms with significant applications in biotechnology. Although many cyanobacteria, including Picosynechococcus sp. (formerly called Synechococcus sp.) PCC 11901 (Picosynechococcus) and Synechocystis sp.
Cecilia Salvagnini   +7 more
wiley   +1 more source

Engineering antibodies with cancer‐associated binding sites

open access: yesBMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy