Results 211 to 220 of about 768,591 (375)

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair-associated gene alterations in solid tumors from a large Asian cohort. [PDF]

BMC Cancer
Ren L, Yao R, Hou T, Liu C, Zhao F, Chen X, Zhang Z, Huang Y.   +7 more
europepmc   +1 more source

Sensitive homologous recombination strand-transfer assay: partial purification of a Drosophila melanogaster enzyme and detection of sequence effects on the strand-transfer activity of RecA protein.

, 1988
James McCarthy, M Sander, Ky Lowenhaupt, Alexander Rich   +3 more
openalex   +1 more source

Enhanced Production of Astaxanthin and Zeaxanthin by Paracoccus Sp. LL1 Through Random Mutagenesis

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Astaxanthin, a high‐value carotenoid with potent antioxidant and anti‐inflammatory activities, is increasingly in demand in various industries. This study reports the successful enhancement of astaxanthin and zeaxanthin production in Paracoccus sp. LL1 through random mutagenesis using ethyl methanesulfonate (EMS).
Anoth Maharjan, Beom Soo Kim
wiley   +1 more source

The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer. [PDF]

Oncologist
Jiang B, Shang Y, Zhang X, He W, Hua H, Ye F, Zhou X, Li Y, Zhong W, Jiang W, Wu G.   +10 more
europepmc   +1 more source

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Nature Genetics, 2017
P. Polak, Jaegil Kim, L. Braunstein, R. Karlić, Nicholas J Haradhavala, G. Tiao, D. Rosebrock, D. Livitz, Kirsten Kübler, K. Mouw, A. Kamburov, Y. Maruvka, I. Leshchiner, E. Lander, T. Golub, A. Zick, Alexandre Orthwein, M. Lawrence, R. Batra, C. Caldas, D. Haber, P. Laird, Hui Shen, L. Ellisen, A. D’Andrea, S. Chanock, W. Foulkes, G. Getz   +27 more
semanticscholar   +1 more source

Approaches to repurposing reverse transcriptase antivirals in cancer

British Journal of Clinical Pharmacology, EarlyView.
This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
wiley   +1 more source

Homologous recombination in the tandem calmodulin genes of Trypanosoma brucei yields multiple products: compensation for deleterious deletions by gene amplification. [PDF]

, 1991
Josiane E. Eid, B Sollner-Webb
openalex   +1 more source

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline

BioEssays, EarlyView.
Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley   +1 more source

Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination. [PDF]

Nat Commun
Deveryshetty J, Mistry A, Pangeni S, Ghoneim M, Tokmina-Lukaszewska M, Gore SK, Liu J, Kaushik V, Karunakaran S, Taddei A, Heyer WD, Ha T, Bothner B, Antony E.   +13 more
europepmc   +1 more source

Extrachromosomal homologous DNA recombination in plant cells is fast and is not affected by CpG methylation. [PDF]

, 1992
Holger Puchta, Serge Kocher, Barbara Höhn   +2 more
openalex   +1 more source