Results 211 to 220 of about 766,679 (374)

Positive genetic selection for gene disruption in mammalian cells by homologous recombination.

, 1989
John M. Sedivy, Phillip A. Sharp
openalex   +1 more source

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity

Science Translational Medicine, 2017
Parker L. Sulkowski, C. Corso, Nathaniel D. Robinson, Susan E. Scanlon, K. Purshouse, Hanwen Bai, Yanfeng Liu, R. Sundaram, D. Hegan, N. Fons, Gregory A. Breuer, Yuanbin Song, K. Mishra-Gorur, Henk M. de Feyter, R. D. de Graaf, Y. Surovtseva, M. Kachman, Stephanie Halene, Murat Günel, P. Glazer, R. Bindra   +20 more
semanticscholar   +1 more source

Lipophilic Resazurin in Bioelectrochemical Systems: Role in Regulating Carbon Metabolic Pathways

ChemElectroChem, EarlyView.
This study clarifies the mechanism by which lipophilic shuttles regulate carbon metabolism in Shewanella. Lipophilic electron shuttles, such as resazurin, permeate into the periplasm to mediate extracellular electron transfer, thereby altering the redox potential sensed by inner‐membrane quinones and consequently activating the NADH‐dependent metabolic
Siyu Tan, Xiao Zhu, Xinxin Wang, Huangsheng Su, Zongqiang Zhu, Xiaobo Luo, John R. Reinfelder, Yundang Wu, Fangbai Li   +8 more
wiley   +1 more source

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair-associated gene alterations in solid tumors from a large Asian cohort. [PDF]

BMC Cancer
Ren L, Yao R, Hou T, Liu C, Zhao F, Chen X, Zhang Z, Huang Y.   +7 more
europepmc   +1 more source

Reversion of Q beta RNA phage mutants by homologous RNA recombination [PDF]

, 1992
Kampan Palasingam, Patrick N. Shaklee
openalex   +1 more source

The Molecular Properties of Honey Bee Acetylcholinesterase Reveal Opportunities to Avoid Off‐Target Effects in Insecticide Discovery

Chemistry – A European Journal, EarlyView.
The structure, dynamics, and kinetics of the essential enzyme acetylcholinesterase (AChE) of honey bee have been studied and compared to AChEs in mosquitoes and mammalians. Profiling of the active sites with selected substrates and AChE inhibitors revealed dramatic differences between the species.
Cecilia Lindgren, Rajeshwari Rajeshwari, Cecilia Springer Engdahl, Rashmi Kumari, Fredrik Ekström, Anna Linusson   +5 more
wiley   +1 more source

The prognostic and predictive value of homologous recombination deficiency in gastrointestinal cancer. [PDF]

Oncologist
Jiang B, Shang Y, Zhang X, He W, Hua H, Ye F, Zhou X, Li Y, Zhong W, Jiang W, Wu G.   +10 more
europepmc   +1 more source

A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

Nature Genetics, 2017
P. Polak, Jaegil Kim, L. Braunstein, R. Karlić, Nicholas J Haradhavala, G. Tiao, D. Rosebrock, D. Livitz, Kirsten Kübler, K. Mouw, A. Kamburov, Y. Maruvka, I. Leshchiner, E. Lander, T. Golub, A. Zick, Alexandre Orthwein, M. Lawrence, R. Batra, C. Caldas, D. Haber, P. Laird, Hui Shen, L. Ellisen, A. D’Andrea, S. Chanock, W. Foulkes, G. Getz   +27 more
semanticscholar   +1 more source

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

Cytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou, Maria C. Burns, Aynsley McDermott, Karolina Jaworek, Stacey J. Scott, James G. Wakefield, Lori Borgal   +6 more
wiley   +1 more source

Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA.

, 1988
Guo-Liang Yu, Miriam S. Hasson, Elizabeth H. Blackburn   +2 more
openalex   +1 more source