Results 211 to 220 of about 348,739 (321)

Fig. S1 from Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death

, 2023
Rita A. Avelar, Amy J. Armstrong, Gracie Carvette, Riya Gupta, Noah Puleo, Jose A. Colina, Peronne Joseph, Alexander M. Sobeck, Caitlin M. O’Connor, Brynne Raines, Agharnan Gandhi, Michele L. Dziubinski, S. Daniel, Kimberly Resnick, Sareena Singh, Kristine Zanotti, Christa Nagel, Steven Waggoner, Daffyd G. Thomas, Stephanie L. Skala, Junran Zhang, Goutham Narla, Analisa DiFeo   +22 more
openalex   +1 more source

The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks

BioEssays, EarlyView.
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley   +1 more source

Cohesin reconstitution and homologous recombination repair of DNA double-strand breaks in late mitosis. [PDF]

Elife
Ayra Plasencia J, Medina-Suárez S, Hernández-Carralero E, García-Luis J, Symington LS, Machín F.   +5 more
europepmc   +1 more source

Induction of recombination between homologous and diverged DNAs by double-strand gaps and breaks and role of mismatch repair

, 1994
S D Priebe, James W. Westmoreland, Torsten Nilsson‐Tillgren, Michael A. Resnick   +3 more
openalex   +2 more sources

Development of Peptide Glucosyltransferase Inhibitors With Comprehensive Coverage Across Clostridioides difficile Toxin B Sub‐Types

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Clostridioides difficile infection presents an escalating clinical challenge due to the proliferation of hypervirulent and antibiotic‐resistant strains. The primary symptoms of disease, namely colitis and diarrhea, are induced by the release of two toxins: TcdA and TcdB.
Carly M. Catella, Sudeep Sarma, Caroline M. Hinesley, Corey E. Febo, Keith A. Breau, Deniz Durmusoglu, Ethan Purnell, Scott T. Magness, Carol K. Hall, Stefano Menegatti, Nathan Crook   +10 more
wiley   +1 more source

Pan-cancer analysis of homologous recombination deficiency and homologous recombination repair-associated gene alterations in solid tumors from a large Asian cohort. [PDF]

BMC Cancer
Ren L, Yao R, Hou T, Liu C, Zhao F, Chen X, Zhang Z, Huang Y.   +7 more
europepmc   +1 more source

A coarse-graining, ultrametric approach to resolve the phylogeny of prokaryotic strains with frequent homologous recombination

, 2020
Tin Yau Pang
openalex   +1 more source

Selection-free, high frequency genome editing by homologous recombination of human pluripotent stem cells using Cas9 RNP and AAV6 [PDF]

, 2018
Renata M. Martin, Kazuya Ikeda, Nobuko Uchida, Kyle Cromer, T. Nishimura, Daniel P. Dever, Joab Camarena, Rasmus O. Bak, Anders Laustsen, Martin R. Jakobsen, Volker Wiebking, Vittorio Sebastiano, Hiromitsu Nakauchi, Matthew H. Porteus   +13 more
openalex   +1 more source

The INSPECTOR study: enhanced feasibility for clinical translation of a multi‐cancer early detection method based on enzyme‐assisted high signal‐to‐noise ratio sequencing of methylated circulating tumor DNA

Cancer Communications, EarlyView.
Abstract Background Blood‐based cell‐free DNA (cfDNA) methylation testing has emerged as a promising approach for multi‐cancer early detection (MCED), holding the potential to improve cancer survival rates. However, traditional bisulfite‐based methods often encounter sensitivity limitations in detecting early‐stage malignancies or certain cancer types.
Hui‐Yan Luo, Wei Wei, Pansong Li, Qi‐Hua Zhang, Zhipeng Zhou, Liang Cui, Yong‐Bin Lin, Hong Yang, Xianyu Zhong, Qingfeng Liu, Han Yang, Kong‐Jia Luo, Hai‐Bo Qiu, Shu‐Qiang Yuan, Yuan‐Fang Li, Zhi‐Wei Zhou, Xiao‐Jun Lin, Bo‐Kang Cui, Rong‐Xin Zhang, Wen‐Hua Fan, He Huang, Chun‐Yan Lan, Jun‐Dong Li, Zhi‐Qiang Wang, Bin‐Kui Li, Rong‐Ping Guo, Jun Tang, Xin Huang, Mian Xi, Yuying Liu, Chuanbo Xie, Shi Chen, Zhi‐Hu Li, Yu‐Hua Liu, Xiao‐Ting Zhang, Qiang Zeng, Xin Yi, Rui‐Hua Xu   +37 more
wiley   +1 more source

Functional characterization of BRCA1 variants of unknown significance using homologous recombination repair assays. [PDF]

Breast Cancer Res
Martín-Bejarano P, Sánchez-Tapia EM, Jessica P, Martín-Gómez T, Tocino RV, González-Sarmiento R, Herrero AB.   +6 more
europepmc   +1 more source