Results 231 to 240 of about 766,679 (374)

Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations. [PDF]

ACS Chem Biol
Lu X, Sauter B, Keller A, Zhanybekova S, Gillingham D.   +4 more
europepmc   +1 more source

The Role and Fate of DNA Ends for Homologous Recombination in Embryonic Stem Cells [PDF]

, 1992
Paul Hasty, Jaime A. Rivera‐Pérez, Allan Bradley   +2 more
openalex   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays. [PDF]

J Mol Diagn
Lara Gutierrez A, Halbwedl I, Sauer S, Regitnig P, Petru E, Seeböck R, Schubert S, Peternell C, Bodó K, Prein K, Kashofer K.   +10 more
europepmc   +1 more source

Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker [PDF]

, 1993
Marcelo Rubinstein, Miguel Á. Japón, Malcolm J. Low   +2 more
openalex   +1 more source

Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley   +1 more source

Homology-arm length of donor DNA affects the impact of Msh2 loss on homologous recombination-mediated gene targeting. [PDF]

Proc Natl Acad Sci U S A
Saito S, Suzuki T, Nohmi T, Adachi N.
europepmc   +1 more source

Comparison of homologous recombination frequencies in somatic cells of petunia and tobacco suggest two distinct recombination pathways [PDF]

, 1992
Peter Engels, Peter Meyer
openalex   +1 more source

Homologous Recombination in Human Mitochondria?

The American Journal of Human Genetics, 1997
openaire   +3 more sources

Clinical Characteristics and Survival of Ovarian Cancer Patients According to Homologous Recombination Deficiency Status. [PDF]

Cancers (Basel)
Sisman Y, Schejbel L, Schnack TH, Høgdall C, Høgdall E.   +4 more
europepmc   +1 more source