Results 241 to 250 of about 773,827 (377)

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination. [PDF]

Commun Biol
Wu X, Zhang Q, Li C, Zhuang S, Liu H, Jiao X, Zhao S, Qin Y, Guo T.   +8 more
europepmc   +1 more source

Multiplex and homologous recombination–mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9

Nature Biotechnology, 2013
Jian-Feng Li, J. Norville, John D Aach, M. McCormack, Dandan Zhang, Jenifer Bush, G. Church, J. Sheen   +7 more
semanticscholar   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Moss BRCA2 lacking the canonical DNA-binding domain promotes homologous recombination and binds to DNA. [PDF]

Nucleic Acids Res
Chanteau A, Quilleré S, Crouset A, Allipra S, Tuquoi U, Perroud PF, Miron S, Dupaigne P, Zinn-Justin S, Nogué F, Kumar R.   +10 more
europepmc   +1 more source

Repression of BET activity sensitizes homologous recombination–proficient cancers to PARP inhibition

Science Translational Medicine, 2017
Lu Yang, Youyou Zhang, Weiwei Shan, Zhongyi Hu, Jiao Yuan, Jingjiang Pi, Yueying Wang, L. Fan, Zhaoqing Tang, Chunsheng Li, Xiaowen Hu, J. Tanyi, Yi Fan, Qihong Huang, K. Montone, C. Dang, Lin Zhang   +16 more
semanticscholar   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

ChemBioChem, EarlyView.
GA: Genetically encoded internal electrophiles in ubiquitin (Ub) enable the profiling of multivalent interaction interfaces, addressing a key limitation of current Ub‐based activity‐based probes. In this study, these probes capture a Ub–deubiquitinase interaction with minimal structural perturbation and serve as selective diUb probes that covalently ...
Nipuni M. Pannala, Rishi S. Patel, Abhijith Saseendran Anit, Debapriya Bhattacharya, Kristos Negron Teron, Bryon Drown, Rudi Fasan, Chittaranjan Das   +7 more
wiley   +1 more source

Homologous recombination and evolutionary arms race drive the adaptive evolution of African swine fever virus. [PDF]

Vet Res
Wang W, Liu Q, Zhao Q, Zhu Z, Wen W, Zhang Z, Li X.   +6 more
europepmc   +1 more source

The uraA locus and homologous recombination in Mycobacterium bovis BCG

, 1993
Anna Aldovini, Robert N. Husson, R A Young   +2 more
openalex   +1 more source

Taming m‐Quionodimethanes by Dispersion Force: Cyclodimerization of (Trialkylsilyl)Ethynyl‐Substituted Indeno[2,1‐b]Fluorenes and Fluoreno[2,3‐b]Fluorenes

Chemistry – A European Journal, EarlyView.
Indeno[2.1‐b]fluorenes and fluoreno[2,3‐b]fluorenes having (trialkylsilyl)ethynyl groups dimerize spontaneously to yield the cyclodimers in the yields ranging from virtually zero to quantitative depending on the alkyl group. The regioselectivity of the bond formation (Head versus Tail) is also dependent on the alkyl group.
Ching‐En Hung, Hsin‐Chung Lin, Rumi Ozawa, Yogajivan Rout, Hirokazu Miyoshi, Yutaka Ie, Ichiro Hisaki, Yen‐Ju Cheng, Yoshito Tobe   +8 more
wiley   +1 more source