Results 241 to 250 of about 345,396 (332)

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, EarlyView.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Domain-Specific DNA Binding Activities of BRCA1 Reveal Substrate Preferences for Homologous Recombination and Telomere Regulation. [PDF]

Biochemistry
Lowran K, Campbell L, Cismas E, Wu CG.
europepmc   +1 more source

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock‐ins

Developmental Dynamics, EarlyView.
Abstract Background The ability to generate endogenous Cre recombinase drivers using CRISPR‐Cas9 knock‐in technology allows lineage tracing, cell type‐specific gene studies, and in vivo validation of inferred developmental trajectories from phenotypic and gene expression analyses. This report describes endogenous zebrafish hand2 Cre and CreERT2 drivers
Zhitao Ming, Fang Liu, Hannah R. Moran, Robert L. Lalonde, Megan Adams, Nicole K. Restrepo, Parnal Joshi, Stephen C. Ekker, Karl J. Clark, Iddo Friedberg, Saulius Sumanas, Chunyue Yin, Christian Mosimann, Jeffrey J. Essner, Maura McGrail   +14 more
wiley   +1 more source

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination. [PDF]

Commun Biol
Wu X, Zhang Q, Li C, Zhuang S, Liu H, Jiao X, Zhao S, Qin Y, Guo T.   +8 more
europepmc   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

USP4 Auto-Deubiquitylation Promotes Homologous Recombination. [PDF]

Mol Cell
Wijnhoven P, Konietzny R, Blackford AN, Travers J, Kessler BM, Nishi R, Jackson SP.   +6 more
europepmc   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Moss BRCA2 lacking the canonical DNA-binding domain promotes homologous recombination and binds to DNA. [PDF]

Nucleic Acids Res
Chanteau A, Quilleré S, Crouset A, Allipra S, Tuquoi U, Perroud PF, Miron S, Dupaigne P, Zinn-Justin S, Nogué F, Kumar R.   +10 more
europepmc   +1 more source

Distribution of exchanges upon homologous recombination of exogenous DNA in Xenopus laevis oocytes.

, 1994
Dana Carroll, Chris W. Lehman, S Jeong-Yu, Paul R. Dohrmann, Renee J. Dawson, Jonathan K. Trautman   +5 more
openalex   +2 more sources

Multi‐Energy Integrated Photocatalysis for Antitumor Therapy

Exploration, EarlyView.
This comprehensive review summarizes recent advancements in piezo‐photocatalysts and photothermal‐photocatalysts for cancer therapy. It begins by outlining the principles of piezo‐photocatalysis and photothermal‐photocatalysis, followed by a discussion of various multi‐energy integrated photocatalysts designed for single‐, dual‐, triple‐, and tetra ...
Li Zhang, Jun Liu, Yuxuan Xiong, Guangfu Liao, Yonggang Lv   +4 more
wiley   +1 more source