Results 261 to 270 of about 348,739 (321)

USP4 Auto-Deubiquitylation Promotes Homologous Recombination. [PDF]

Mol Cell
Wijnhoven P, Konietzny R, Blackford AN, Travers J, Kessler BM, Nishi R, Jackson SP.   +6 more
europepmc   +1 more source

Domain-Specific DNA Binding Activities of BRCA1 Reveal Substrate Preferences for Homologous Recombination and Telomere Regulation. [PDF]

Biochemistry
Lowran K, Campbell L, Cismas E, Wu CG.
europepmc   +1 more source

Additional file 2: Table S2. of Serine/arginine-rich splicing factor 3 (SRSF3) regulates homologous recombination-mediated DNA repair

, 2015
Xiaolong He, Pei Zhang
openalex   +1 more source

KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma. [PDF]

Signal Transduct Target Ther
Wu J, Yuan J, Liu Z, Zhou Y, Zhang B, Xu Y, Zeng Q, Wu Z, Kong L, Wang J, Zhang B, Yang J, Lv T, Shi Y, Yang J.   +14 more
europepmc   +1 more source

4P Mutational landscape of ovarian cancer patients (pts) by homologous recombination deficiency (HRD) status

D. Montanari, Valentina Zampiga, Ilaria Cangini, Erika Bandini, Cláudia Casanova, Giuseppe Comerci, Valentina Arcangeli, Marta Rosati, F. Rosati, Marco Stefanetti, Salvatore Luca Burgio, Isabella Strada, Paolo Maniglio, Mauro Rossi, Ugo De Giorgi, Alberto Farolfi   +15 more
openalex   +1 more source

Optimizing the integration of modern systemic therapies and advanced radiotherapy techniques in breast cancer management: An expert opinion from the Institut Curie Breast Radiotherapy Group

International Journal of Cancer, EarlyView.
Abstract The integration of modern systemic therapies with radiotherapy (RT) represents a promising strategy in breast cancer management, enhancing both locoregional control and systemic disease outcomes. This expert consensus from the Institut Curie Breast Radiotherapy Group focuses exclusively on modern systemic agents, synthesizing current evidence ...
Cezara Cheptea, Pierre Loap, Sofiane Allali, Alain Fourquet, Kim Cao, Youlia Kirova   +5 more
wiley   +1 more source

Data from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

Katherine Sullivan-Reed, Monika M. Toma, Małgorzata Drzewiecka, Margaret Nieborowska-Skorska, Reza Nejati, Adam Karami, Mariusz A. Wasik, Tomasz Śliwiński, Tomasz Skórski   +8 more
openalex   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, EarlyView.
What's New? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Biallelic BRCA2 variants induce premature ovarian insufficiency by impaired meiotic homologous recombination. [PDF]

Commun Biol
Wu X, Zhang Q, Li C, Zhuang S, Liu H, Jiao X, Zhao S, Qin Y, Guo T.   +8 more
europepmc   +1 more source

Delivering precision oncology in metastatic breast cancer: Clinical impact of comprehensive genomic profiling—The CATCH experience

International Journal of Cancer, EarlyView.
What's New? CATCH is a prospective precision oncology registry trial that harnesses whole‐genome/exome‐ and RNA‐sequencing to enable actionable biomarker detection in metastatic breast cancer patients of any subtype. The data of the first 412 consecutive patients with completed follow‐up in this real‐world, single‐center patient cohort provide robust ...
Mario Hlevnjak, Sabine Heublein, Verena Thewes, Lukas Wagener, Constantin Pixberg, Carlo Fremd, Laura Michel, Christian Maurer, Lars Buschhorn, Nicola Dikow, Fangyoumin Feng, Stefan Fröhling, Christel Herold‐Mende, Steffen Hirsch, Chen Hong, Daniel Hübschmann, Lena Jassowicz, Polina Kozyulina, Katrin Pfütze, Richard F. Schlenk, Hans‐Peter Sinn, Katharina Smetanay, Christoph Springfeld, Albrecht Stenzinger, Celina Wagner, Stephan Wolf, Andreas Trumpp, Dirk Jäger, Oliver Zivanovic, Marc Zapatka, Andreas Schneeweiss, Peter Lichter   +31 more
wiley   +1 more source