Results 261 to 270 of about 345,396 (332)

Transformation-associated recombination between diverged and homologous DNA repeats is induced by strand breaks

, 1993
V. Larionov, Natalay Kouprina, M. Edlarov, Edward L. Perkins, Gregory Porter, Michael A. Resnick   +5 more
openalex   +2 more sources

Mechanisms of enhancer‐driven oncogene activation

International Journal of Cancer, EarlyView.
Abstract An aggressive subtype of acute myeloid leukemia (AML) is caused by enhancer hijacking resulting in MECOM overexpression. Several chromosomal rearrangements can lead to this: the most common (inv(3)/t(3;3)) results in a hijacked GATA2 enhancer, and there are several atypical MECOM rearrangements involving enhancers from other hematopoietic ...
Joyce Vriend, Ruud Delwel, Dorien Pastoors   +2 more
wiley   +1 more source

Unraveling Homologous Recombination Deficiency in Ovarian Cancer: A Review of Currently Available Testing Platforms. [PDF]

Cancers (Basel)
Marconato N, Tommasi O, Paladin D, Boscarino D, Spagnol G, Saccardi C, Maggino T, Tozzi R, Noventa M, Marchetti M.   +9 more
europepmc   +1 more source

Optimizing the integration of modern systemic therapies and advanced radiotherapy techniques in breast cancer management: An expert opinion from the Institut Curie Breast Radiotherapy Group

International Journal of Cancer, EarlyView.
Abstract The integration of modern systemic therapies with radiotherapy (RT) represents a promising strategy in breast cancer management, enhancing both locoregional control and systemic disease outcomes. This expert consensus from the Institut Curie Breast Radiotherapy Group focuses exclusively on modern systemic agents, synthesizing current evidence ...
Cezara Cheptea, Pierre Loap, Sofiane Allali, Alain Fourquet, Kim Cao, Youlia Kirova   +5 more
wiley   +1 more source

Exploring the Potential of Homologous Recombination Protein PALB2 in Synthetic Lethal Combinations. [PDF]

ACS Chem Biol
Lu X, Sauter B, Keller A, Zhanybekova S, Gillingham D.   +4 more
europepmc   +1 more source

Efficient and precise engineering of a 200 kb β-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system

, 1999
Kumaran Narayanan, R. Williamson, Youming Zhang, A. Francis Stewart, P A Ioannou   +4 more
openalex   +1 more source

Olaparib for patients with tumors harboring alterations in homologous recombination repair genes: Results from the drug rediscovery protocol

International Journal of Cancer, EarlyView.
What's New? PARP inhibitors are effective in patients with inactivating alterations in the BRCA1/2 genes across tumor types. However, the efficacy of PARP inhibitors in patients with other inactivated homologous recombination repair genes remains unclear. This knowledge gap and discrepancies in EMA/FDA approvals highlight the need for better biomarkers.
Ilse A. C. Spiekman, Niven Mehra, Laurien J. Zeverijn, Birgit S. Geurts, Karlijn Verkerk, Soemeya F. Haj Mohammad, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Addy C. M. van de Luijtgaarden, Theo van Voorthuizen, Tineke E. Buffart, Hans Gelderblom, Emile E. Voest, Henk M. W. Verheul   +15 more
wiley   +1 more source

Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays. [PDF]

J Mol Diagn
Lara Gutierrez A, Halbwedl I, Sauer S, Regitnig P, Petru E, Seeböck R, Schubert S, Peternell C, Bodó K, Prein K, Kashofer K.   +10 more
europepmc   +1 more source

A Case of Metastatic Castration‐Resistant Prostate Cancer With RAD54L Mutation Responding to Niraparib

IJU Case Reports, EarlyView.
ABSTRACT Introduction A certain proportion of prostate cancers have alterations in homologous recombination repair (HRR)‐ related genes. poly ADP‐ribose polymerase (PARP) inhibitors have been approved for metastatic castration‐resistant prostate cancer (mCRPC) with mutations in the BRCA1/2 gene.
Yusuke Sato, Yoichi Fujii, Masaki Nakamura, Chiharu Tanai, Yuta Yamada, Kousuke Watanabe, Hidenori Kage, Kuniko Sunami, Katsutoshi Oda, Haruki Kume   +9 more
wiley   +1 more source

Prognostic impact of gene alterations via homologous recombination DNA repair gene alteration status in pancreatic ductal adenocarcinoma. [PDF]

Front Med (Lausanne)
Kawanaka Y, Inagaki C, Okura M, Mitani S, Takahama T, Yonesaka K, Chiba Y, Nakagawa K, Kawakami H, Hayashi H.   +9 more
europepmc   +1 more source