Results 281 to 290 of about 345,396 (332)

Clinical Characteristics and Survival of Ovarian Cancer Patients According to Homologous Recombination Deficiency Status. [PDF]

Cancers (Basel)
Sisman Y, Schejbel L, Schnack TH, Høgdall C, Høgdall E.   +4 more
europepmc   +1 more source

Unveiling Cell‐Type‐Specific Immune Reactions in Human Blood Following Varied Fruit and Vegetable Blends Interventions

Molecular Nutrition &Food Research, EarlyView.
Paired peripheral‐blood RNA‐seq from MiBLEND was deconvolved with CIBERSORTx to profile leukocyte composition and cell‐type‐specific transcriptomic responses to seven fruit‐and‐vegetable blends. Deconvolution yielded 22 leukocyte subtypes that correlated with laboratory WBC reports (R = 0.886, p ≤ 0.01).
Yueqin He, Julia N. DeBenedictis, Simone G. van Breda, Theo M. de Kok   +3 more
wiley   +1 more source

Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer. [PDF]

J Clin Invest
Schab A, Compadre A, Drexler R, Loeb M, Rodriguez K, Brill J, Harrington S, Sandoval C, Sanders B, Kuroki L, McCourt C, Hagemann AR, Thaker P, Mutch D, Powell M, Serra V, Hagemann IS, Walts AE, Karlan BY, Orsulic S, Fuh KC, Sun L, Verma P, Lomonosova E, Zhao P, Khabele D, Mullen MM.   +26 more
europepmc   +1 more source

Androgen receptor‐mediated regulation of BRCA1 modulates the antioxidant defense in prostate cancer

The Journal of Pathology, EarlyView.
Abstract Lethal prostate cancer (PCa) is a genetically heterogeneous disease characterized by evolving androgen receptor (AR) signaling, eventually culminating in castration resistance. The tumor suppressor gene BRCA1 has multiple functions that include secondary processes cooperating with its main function as a caretaker of genomic integrity. BRCA1 is
Saiganesh Sriraman, Verneri Virtanen, Antti Kukkula, Mervi Toriseva, Anni Lumiainen, Gun West, Matti Poutanen, Pekka Taimen, Maria Sundvall   +8 more
wiley   +1 more source

Long non-coding RNAs as a biomarker for homologous recombination deficiency and parp inhibitor sensitivity in high-grade serous ovarian cancers. [PDF]

Commun Biol
Doberstein K, Panther J, Hahnen E, Richters L, Schouten PC, Harter P, Heitz F, Kommoss S, Berlit S, Tuschy B, Sütterlin M, Marmé F.   +11 more
europepmc   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Genomic Divergence Shaped the Genetic Regulation of Meiotic Homologous Recombination in Brassica Allopolyploids. [PDF]

Mol Biol Evol
Pelé A, Falque M, Lodé-Taburel M, Huteau V, Morice J, Coriton O, Martin OC, Chèvre AM, Rousseau-Gueutin M.   +8 more
europepmc   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source

Distinct age-related effects of homologous recombination deficiency on genomic profiling and treatment efficacy in gastric cancer. [PDF]

J Gastroenterol
Maki Y, Kono Y, Ozato T, Yamamoto H, Hirasawa A, Ennishi D, Tomida S, Toyooka S, Hamada K, Iwamuro M, Kawano S, Otsuka M.   +11 more
europepmc   +1 more source

Single and dual RPA‐CRISPR/Cas assays for point‐of‐need detection of Stewart's wilt pathogen (Pantoea stewartii subsp. stewartii) of corn and Maize dwarf mosaic virus

Pest Management Science, Volume 81, Issue 4, Page 1988-1999, April 2025.
Schematic diagram of the single and dual RPA‐CRISPR/Cas12a/13a diagnostic assays for the detection of Pantoea stewartii subsp. stewartii and Maize dwarf mosaic virus. The validated assays provide a useful and sensitive molecular tool for detecting two quarantine pathogens of maize within a minimal resource framework suitable for fast‐tracking the ...
Qian Tian, Hua Zhou, Zhenxing Zhao, Yongjiang Zhang, Wenjun Zhao, Lulu Cai, Tao Guo   +6 more
wiley   +1 more source