Results 281 to 290 of about 348,739 (321)

Homologous recombination and evolutionary arms race drive the adaptive evolution of African swine fever virus. [PDF]

Vet Res
Wang W, Liu Q, Zhao Q, Zhu Z, Wen W, Zhang Z, Li X.   +6 more
europepmc   +1 more source

Population Pharmacokinetics Analysis of Talazoparib and Enzalutamide Combination Therapy for Patients With Metastatic Castration‐Resistant Prostate Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract The poly(ADP‐ribose) polymerase inhibitor talazoparib, combined with the androgen receptor inhibitor enzalutamide is approved for patients with homologous recombination repair (HRR) gene‐mutated metastatic castration‐resistant prostate cancer (mCRPC) in the US and with mCRPC in whom chemotherapy is not clinically indicated in Europe.
Mark Hadigol, Jason H. Williams, Haihong Shi, Derek Z. Yang, Justin Hoffman, Diane D. Wang   +5 more
wiley   +1 more source

Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells. [PDF]

Cancers (Basel)
Komar ZM, Ladan MM, Verkaik NS, Dahmani A, Montaudon E, Marangoni E, Kanaar R, Nonnekens J, Houtsmuller AB, Jager A, Gent DCV.   +10 more
europepmc   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Comprehensive RAD51C ovarian cancer variant analysis uncouples homologous recombination and replicative functions. [PDF]

Nat Commun
Rein HL, Rawal Y, Palovcak-Lightbourn AL, Ganesan GS, Parker PS, Russell R, Darrah KE, Afsar M, Sullivan MR, Hengel SR, Radke MR, Opresko PL, Yanowitz JL, Greene EC, Lee JM, Domchek SM, Swisher EM, Olsen SK, Sung P, Bernstein KA.   +19 more
europepmc   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Genetic Testing Among Black and White Patients With Advanced Prostate Cancer: A Retrospective Analysis of Testing Utilization and Referral Patterns

The Prostate, EarlyView.
ABSTRACT Purpose Genetic testing is recommended but underutilized in advanced prostate cancer. Given known disparities affecting Black patients, we assessed genetic testing completion rates by race. Methods Henry Ford Health's electronic medical record was queried for new prostate cancer diagnoses (1/1/2017–6/30/2022).
Kyle C. McElyea, James P. Purtell, Avery K. Supernois, Courtney M. Rose, Farhan Ibrahim, Mohammed A. Baseer, Sunita Ghosh, Clara Hwang   +7 more
wiley   +1 more source

Unraveling Homologous Recombination Deficiency in Ovarian Cancer: A Review of Currently Available Testing Platforms. [PDF]

Cancers (Basel)
Marconato N, Tommasi O, Paladin D, Boscarino D, Spagnol G, Saccardi C, Maggino T, Tozzi R, Noventa M, Marchetti M.   +9 more
europepmc   +1 more source

Comprehensive assessment of homologous recombination deficiency via simultaneous methylation and mutation analysis in epithelial ovarian cancer: implications for PARP inhibitors efficacy. [PDF]

Biomark Res
Dong L, Wu H, Li N, Li W, Song Y, Xiong Y, Yin H, Fang H, Chen R, Yi X, Huang J, Ying J.   +11 more
europepmc   +1 more source

Robust Assessment of Homologous Recombination Deficiency Genomic Instability by OncoScan Microarrays. [PDF]

J Mol Diagn
Lara Gutierrez A, Halbwedl I, Sauer S, Regitnig P, Petru E, Seeböck R, Schubert S, Peternell C, Bodó K, Prein K, Kashofer K.   +10 more
europepmc   +1 more source