Results 281 to 290 of about 789,870 (314)

HRDPath: An Explainable Multi-Model Deep Learning Architecture for Predicting Homologous Recombination Deficiency from Histopathology Images

Wu C, Banda K, Arora R, Soong TR, Radke M, Dillon M, Nik-Zainal S, Swisher E, Sailem H.   +8 more
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Mechanism of Eukaryotic Homologous Recombination

Annual Review of Biochemistry, 2008
Homologous recombination (HR) serves to eliminate deleterious lesions, such as double-stranded breaks and interstrand crosslinks, from chromosomes. HR is also critical for the preservation of replication forks, for telomere maintenance, and chromosome segregation in meiosis I.
Joseph, San Filippo, Patrick, Sung, Hannah, Klein   +2 more
openaire   +3 more sources

Helicobacter pylori, Homologous-Recombination Genes, and Gastric Cancer.

New England Journal of Medicine, 2023
BACKGROUND Helicobacter pylori infection is a well-known risk factor for gastric cancer. However, the contribution of germline pathogenic variants in cancer-predisposing genes and their effect, when combined with H.
Y. Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Y. Kasugai, I. Oze, Hidemi Ito, I. Imoto, Tsutomu Tanaka, M. Tajika, Y. Niwa, Y. Iwasaki, T. Aoi, N. Hakozaki, Sadaaki Takata, Kunihiko Suzuki, C. Terao, M. Hatakeyama, M. Hirata, K. Sugano, Teruhiko Yoshida, Y. Kamatani, H. Nakagawa, K. Matsuda, Yoshinori Murakami, A. Spurdle, K. Matsuo, Y. Momozawa   +27 more
semanticscholar   +1 more source

Recombination | Homologous Recombination in Meiosis

Encyclopedia of Biological Chemistry III, 2021
Nancy M. Hollingsworth, Hani Zaher
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Innovation by homologous recombination

Current Opinion in Chemical Biology, 2013
Swapping fragments among protein homologs can produce chimeric proteins with a wide range of properties, including properties not exhibited by the parents. Computational methods that use information from structures and sequence alignments have been used to design highly functional chimeras and chimera libraries.
Trudeau, Devin L., Smith, Matthew A., Arnold, Frances H.   +2 more
openaire   +3 more sources

Metabolic regulation of homologous recombination repair by MRE11 lactylation

Cell, 2023
Yuping Chen, Jinhuan Wu, Linhui Zhai, Tingting Zhang, Hui Yin, Huanyao Gao, Fei Zhao, Zhe Wang, Xiaoning Yang, Mingpeng Jin, Bingsong Huang, Xin Ding, Rui Li, Jie Yang, Yiming He, Qianwen Wang, Weibin Wang, Jake A. Kloeber, Yunxuan Li, Bingbing Hao, Yuanyuan Zhang, Jiadong Wang, Minjia Tan, Ke Li, Ping Wang, Zhenkun Lou, Jian Yuan   +26 more
semanticscholar   +1 more source

Homologous Recombination in Eukaryotes

2012
Homologous recombination (HR) is a mechanistically conserved pathway that ensures maintenance of genomic integrity. During meiosis, HR results in DNA crossover events between homologous chromosomes that produce the genetic diversity inherent in germ cells.
Ravindra, Amunugama, Richard, Fishel
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BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination

Nature, 2021
Jordan R. Becker, Gillian Clifford, Clara Bonnet, Anja Groth, M. D. Wilson, J. R. Chapman   +5 more
semanticscholar   +1 more source

Activation of homologous recombination in G1 preserves centromeric integrity

Nature, 2021
D. Yilmaz, Audrey Furst, K. Meaburn, Aleksandra Lezaja, Yanlin Wen, M. Altmeyer, B. Reina-San-Martin, Evi Soutoglou   +7 more
semanticscholar   +1 more source

Hotspots of homologous recombination

Experientia, 1994
Homologous recombination occurs at higher than average frequency at and near hotspots. Hotspots are special nucleotide sequences recognized by proteins that promote, directly or indirectly, a rate limiting step of recombination. This review focuses on two well-studied examples, the Chi sites of the bacterium Escherichia coli and the M26 site of the ...
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