Results 81 to 90 of about 348,739 (321)

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Global divergence of microbial genome sequences mediated by propagating fronts

, 2005
We model the competition between recombination and point mutation in microbial genomes, and present evidence for two distinct phases, one uniform, the other genetically diverse.
Berg, Doolittle, Feil, Feil, Feil, Gogarten, Guttman, Ivanova, Joyce, Kurtz, Lawrence, Lawrence, Li, Majewski, Majewski, Milkman, Ochman, Radding, Rasko, Sawyer, Smith, Treves, Tyson, Vulic   +23 more
core   +2 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Enhanced radiosensitivity of head and neck cancer cells to proton therapy via hyperthermia-induced homologous recombination deficiency

Clinical and Translational Radiation Oncology
Background and purpose: Radiotherapy induces tumor cell killing by generating DNA double strand breaks (DSBs). The effectiveness of radiotherapy is significantly influenced by the repair of DSBs, which counteracts this lethal effect.
Tim Heemskerk, Gerarda van de Kamp, Marta Rovituso, Roland Kanaar, Jeroen Essers   +4 more
doaj   +1 more source

Which way up? Recognition of homologous DNA segments in parallel and antiparallel alignment

, 2014
Homologous gene shuffling between DNA promotes genetic diversity and is an important pathway for DNA repair. For this to occur, homologous genes need to find and recognize each other.
Aaron Wynveen, Alexei A. Kornyshev, Dominic J. (O’) Lee, Forsdyke D. R., Leach D. R. F., Lewin B., Tim Albrecht   +6 more
core   +1 more source

Genome characterization and population genetic structure of the zoonotic pathogen, streptococcus canis [PDF]

, 2012
Background - Streptococcus canis is an important opportunistic pathogen of dogs and cats that can also infect a wide range of additional mammals including cows where it can cause mastitis. It is also an emerging human pathogen.
Lang, P., Lefébure, T., Moroni, P., Pavinski Bitar, P.D., Richards, V.P., Stanhope, M.J., Tikofsky, L., Werner, B., Zadoks, R.N.   +8 more
core   +5 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint.

PLoS Genetics, 2008
Heterozygous mutations in the tumor suppressor BRCA2 confer a high risk of breast and other cancers in humans. BRCA2 maintains genome stability in part through the regulation of Rad51-dependent homologous recombination. Much about its precise function in
Martha Klovstad, Uri Abdu, Trudi Schüpbach   +2 more
doaj   +1 more source

Pan-cancer landscape of homologous recombination deficiency

Nature Communications, 2020
Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest ...
Luan Nguyen, John W. M. Martens, Arne Van Hoeck, Edwin Cuppen   +3 more
doaj   +1 more source

Homologous recombination and its regulation [PDF]

Nucleic Acids Research, 2012
Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for chromosomal pairing and exchange during meiosis. However, some forms of HR can also lead to undesirable DNA rearrangements. Multiple regulatory mechanisms have evolved to ensure that HR takes place at the right time, place and manner. Several of these impinge on
Krejci, Lumir, Altmannova, Veronika, Spirek, Mario, Zhao, Xiaolan   +3 more
openaire   +2 more sources