Results 81 to 90 of about 218,555 (316)
Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022 Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem +6 more
wiley +1 more source
Hypothesis: Homologous recombination depends on parallel search [PDF]
arXiv, 2016 It is not known how a cell manages to find a specific DNA sequence sufficiently fast to repair a broken chromosome through homologous recombination. I propose that the solution is based on a parallelized search implemented by freely diffusing molecules programmed with sequences corresponding to those flanking the break site.
arxiv
Orientation Dependence in Homologous Recombination [PDF]
Genetics, 1996 Abstract Homologous recombination was investigated in Escherichia coli with two plasmids, each carrying the homologous region (two defective neo genes, one with an amino-end deletion and the other with a carboxyl-end deletion) in either direct or inverted orientation.
Hiroshi Yoshikura +4 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Ovarian cancer's high recurrence and therapy resistance demand new strategies. A high‐throughput drug screening pipeline using 3D spheroids, which showed poor concordance with 2D models, identified rapamycin as a promising candidate. In combination with cisplatin, rapamycin demonstrated significant in vitro and in vivo efficacy, highlighting the ...
Nazanin Karimnia +9 more
wiley +1 more source
The recombinase protein is a torque sensitive molecular switch [PDF]
arXiv, 2016 How a nano-searcher finds its nano-target is a general problem in non-equilibrium statistical physics. It becomes vital when the searcher is a damaged DNA fragment trying to find its counterpart on the intact homologous chromosome. If the two copies are paired, that intact homologous sequence serves as a template to reconstitute the damaged DNA ...
arxiv
Influence of Human p53 on Plant Development. [PDF]
PLoS ONE, 2016 Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light.
Huimin Ma +3 more
doaj +1 more source
Advanced Optical Materials, EarlyView.Sequential indolo‐fusion π‐extension as a rational design strategy to further narrow the emission bandwidth of multi‐resonance thermally activated delayed fluorescence is introduced. By fusing one or two additional indole moieties to the periphery of Cz‐B, gradual spectra narrowing and accelerated triplet–singlet exciton spin conversion are ...
Hyukgi Min, Takuma Yasuda
wiley +1 more source
Genome analyses and modelling the relationship between coding density, recombination rate and chromosome length [PDF]
arXiv, 2010 In the human genomes, recombination frequency between homologous chromosomes during meiosis is highly correlated with their physical length while it differs significantly when their coding density is considered. Furthermore, it has been observed that the recombination events are distributed unevenly along the chromosomes.
arxiv
G3: Genes, Genomes, Genetics, 2018 Crossover recombination during meiosis is accompanied by a dramatic chromosome reorganization. In Saccharomyces cerevisiae, the onset of meiotic recombination by the Spo11 transesterase leads to stable pairwise associations between previously ...
Lina Yisehak, Amy J. MacQueen
doaj +1 more source
Advanced Science, EarlyView.Wenxiang Meng and colleagues delve into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐
Ninan Zhang +9 more
wiley +1 more source