Results 61 to 70 of about 510,614 (286)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Assembly and dynamics of the bacteriophage T4 homologous recombination machinery

Virology Journal, 2010
Homologous recombination (HR), a process involving the physical exchange of strands between homologous or nearly homologous DNA molecules, is critical for maintaining the genetic diversity and genome stability of species.
Morrical Scott W, Liu Jie
doaj   +1 more source

Recovery of arrested replication forks by homologous recombination is error-prone. [PDF]

PLoS Genetics, 2012
Homologous recombination is a universal mechanism that allows repair of DNA and provides support for DNA replication. Homologous recombination is therefore a major pathway that suppresses non-homology-mediated genome instability.
Ismail Iraqui, Yasmina Chekkal, Nada Jmari, Violena Pietrobon, Karine Fréon, Audrey Costes, Sarah A E Lambert   +6 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.

PLoS Genetics, 2017
Legionella pneumophila is an environmental bacterium and the causative agent of Legionnaires' disease. Previous genomic studies have shown that recombination accounts for a high proportion (>96%) of diversity within several major disease-associated ...
Sophia David, Leonor Sánchez-Busó, Simon R Harris, Pekka Marttinen, Christophe Rusniok, Carmen Buchrieser, Timothy G Harrison, Julian Parkhill   +7 more
doaj   +1 more source

Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier [PDF]

, 2011
Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death.
Ledesma, Jennifer, Whitby, Matthew C., Castagnetti, S, Sofueva, Sevil, Alexander Lorenz, Steinacher, R, Fekret Osman, Lorenz, Alexander, Sofueva, S, Ledesma, J, Castagnetti, Stefania, Whitby, Matthew, Steinacher, Roland, Sevil Sofueva, Stefania Castagnetti, Osman, F, Lorenz, A, Matthew C. Whitby, Whitby, MC, Osman, Fekret, Roland Steinacher, Jennifer Ledesma   +21 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Recombination and Its Impact on the Genome of the Haplodiploid Parasitoid Wasp Nasonia [PDF]

, 2010
Homologous meiotic recombination occurs in most sexually reproducing organisms, yet its evolutionary advantages are elusive. Previous research explored recombination in the honeybee, a eusocial hymenopteran with an exceptionally high genome-wide ...
Gibson, Joshua D., Gadau Jürgen, Desjardins, Christopher A.,, Kennedy Kathleen, Beukeboom, Leo W.,, Koevoets Tosca, Kennedy, Kathleen,, Gibson Joshua D., Werren, John H., Gibson, Joshua D.,, Koevoets, Tosca, van de Zande, Louis, Gadau, Jürgen, Shuker David M., Niehuis, Oliver, Joshua D Gibson, Leo W Beukeboom, Judson, Andrea K.,, David M. Shuker, Andrea K Judson, Duggan, David,, David Duggan, Shuker, David M.,, Niehuis, Oliver,, David M Shuker, Beukeboom Leo W., van de Zande Louis, Christopher A Desjardins, Bart A. Pannebakker, Rosenberg, Michael S., Duggan, David, Kathleen Kennedy, Gadau, Jürgen,, Shuker, David Michael, Gadau, Juergen, van de Zande, Louis; id_orcid, Andrea K. Judson, John H Werren, Judson, Andrea K., Kennedy, Kathleen, Werren, John H.,, Pannebakker Bart A., Michael S. Rosenberg, Tosca Koevoets, Louis van de Zande, Beukeboom, Leo W., Werren John H., John H. Werren, Jürgen Gadau, Pannebakker, Bart A., Duggan David, Niehuis Oliver, Christopher A. Desjardins, Pannebakker, Bart A.,, Leo W. Beukeboom, Desjardins, Christopher A., Oliver Niehuis, Joshua D. Gibson, Rosenberg Michael S., Bart A Pannebakker, Michael S Rosenberg, Koevoets, Tosca,, Judson Andrea K., Zande, Louis van de,, Rosenberg, Michael S.,, Shuker, David M., Desjardins Christopher A.   +66 more
core   +3 more sources

A Model of Non-Homologous Recombination Mediated by HIV-1 Reverse Transcriptase Explaining Sequence Motif Duplications That Confer a Replication Fitness Advantage

Viruses
The Reverse Transcriptase of the Human Immunodeficiency Virus (HIV) is distinguished by its high rate of homologous recombination. A less-studied consequence of this phenomenon is the increased occurrence of non-homologous recombination, which results in
Arun Panchapakesan, Udaykumar Ranga
doaj   +1 more source

Homologous recombination, sister chromatid cohesion, and chromosome condensation in mammalian meiosis [PDF]

, 2002
In the life cycle of sexually reproducing eukaryotes, haploid and diploid generations of cells alternate. Two types of cell division occur in such a life cycle: mitosis and meiosis. They are compared in chapter 1 .
Eijpe, M.
core