Results 121 to 130 of about 762,366 (142)

Curcumin Induces Homologous Recombination Deficiency by BRCA2 Degradation in Breast Cancer and Normal Cells. [PDF]

Cancers (Basel)
Komar ZM, Ladan MM, Verkaik NS, Dahmani A, Montaudon E, Marangoni E, Kanaar R, Nonnekens J, Houtsmuller AB, Jager A, Gent DCV.   +10 more
europepmc   +1 more source

Complex Relationships Between Homologous Recombination Deficiency (HRD) Score and Mutational Status of Homologous Recombination Repair (HRR) Genes in Prostate Carcinomas. [PDF]

Int J Mol Sci
Iyevleva AG, Aleksakhina SN, Sokolenko AP, Otradnova EA, Nikitina AS, Kashko KA, Syomina MV, Shestakova AD, Kuligina ES, Morozova NS, Popov SV, Vyazovcev PV, Luchkova TY, Peremyshlenko AS, Topuzov TM, Gudkova OM, Orlova RV, Levushkin AV, Moiseev DO, Shkodenko ON, Gubarev DV, Dzyuba AV, Povorina IY, Agaeva AV, Kutyan VF, Grigoryan MM, Orlov AN, Lefterov SI, Belousov AV, Nechaeva MN, Vorobyeva EN, Amirkhanova IK, Kryukova NV, Zatulivetrova LI, Gomboeva AB, Krivtsov VN, Shchiglik OI, Prokudina NV, Butunina NA, Belyaev AM, Imyanitov EN.   +40 more
europepmc   +1 more source

Homologous recombination deficiency in newly diagnosed advanced ovarian cancer across nine Middle East countries: prevalence, real-world testing pathways, and treatment implications. [PDF]

BMC Cancer
Shash E, Vardar MA, Taskiran C, Boujassoum S, Riromar J, Aboutaleb A, Sadek F, Samy E, Bahaj W.   +8 more
europepmc   +1 more source

HRDPath: An Explainable Multi-Model Deep Learning Architecture for Predicting Homologous Recombination Deficiency from Histopathology Images

Wu C, Banda K, Arora R, Soong TR, Radke M, Dillon M, Nik-Zainal S, Swisher E, Sailem H.   +8 more
europepmc   +1 more source

Homologous Recombination Repair Deficiency: An Overview for Pathologists

Modern Pathology, 2023
The repair of DNA double-stranded breaks relies on the homologous recombination repair pathway and is critical to cell function. However, this pathway can be lost in some cancers such as breast, ovarian, endometrial, pancreatic, and prostate cancers ...
Stephen Fox, Ken Doig
exaly   +2 more sources

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European experts consensus: BRCA/homologous recombination deficiency testing in first-line ovarian cancer

Annals of Oncology, 2022
Massimo Barberis, Diether Lambrechts, Ana Oaknin   +2 more
exaly  

Hereditary cancer variants and homologous recombination deficiency in biliary tract cancer

Journal of Hepatology, 2023
Koichi Matsuda, Hidewaki Nakagawa, Todd A. Johnson   +2 more
exaly  

Ovarian Cancer Therapy: Homologous Recombination Deficiency as a Predictive Biomarker of Response to PARP Inhibitors

OncoTargets and Therapy, 2022
Osnat Elyashiv, Rowan E Miller, Jonathan A Ledermann   +2 more
exaly  

ESMO recommendations on predictive biomarker testing for homologous recombination deficiency and PARP inhibitor benefit in ovarian cancer

Annals of Oncology, 2020
Serena Nik-Zainal, Violeta Serra, A Leary   +2 more
exaly  

Homologous recombination deficiency predicts the response to platinum-based neoadjuvant chemotherapy in early-stage triple-negative breast cancer patients: a systematic review and meta-analysis

Therapeutic Advances in Medical Oncology, 2022
Yuanqi Chen, Min-Yi Cheng
exaly