Results 271 to 280 of about 137,826 (378)

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

CG>TG mutation frequency as negative predictor of homologous recombination deficiency in ovarian and breast cancer. [PDF]

Commun Biol
Romanovsky E, Menzel M, Kluck K, Beck S, Ball M, Schirmacher P, Kazdal D, Stenzinger A, Budczies J.   +8 more
europepmc   +1 more source

Author Correction: Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features [PDF]

, 2019
Jason J. Pitt, Markus Riester, Yonglan Zheng, Toshio F. Yoshimatsu, Ayodele Sanni, Olayiwola Oluwasola, Artur Veloso, Emma Labrot, Shengfeng Wang, Abayomi Odetunde, Adeyinka Ademola, Babajide Okedere, Scott Mahan, Rebecca Leary, Maura Macomber, Mustapha Ajani, Ryan Johnson, Dominic Fitzgerald, A. Jason Grundstad, Jigyasa H. Tuteja, Galina Khramtsova, Jing Zhang, Elisabeth Sveen, Bryce Hwang, Wendy Clayton, Chibuzor Nkwodimmah, Bisola Famooto, Esther Obasi, Victor Aderoju, Mobolaji A. Oludara, Folusho Omodele, Odunayo Akinyele, Adewunmi Adeoye, Temidayo O. Ogundiran, Chinedum P. Babalola, Kenzie D. MacIsaac, Abiodun Popoola, Michael Morrissey, Lin Chen, Jiebiao Wang, Christopher O. Olopade, Adeyinka G. Falusi, Wendy Winckler, Kerstin Haase, Peter Van Loo, John Obafunwa, D Papoutsakis, Oladosu Ojengbede, Barbara L. Weber, Nasiru Ibrahim, Kevin P. White, Dezheng Huo, Olufunmilayo I. Olopade, Jordi Barretina   +53 more
openalex   +1 more source

Homologous recombination deficiency: New biomarkers in innovative treatments [PDF]

memo - Magazine of European Medical Oncology, 2020
openaire   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

A Novel Droplet Digital PCR Assay for BRCA1 and RAD51C Methylation: Advancing Homologous Recombination Deficiency Detection in Ovarian Cancer. [PDF]

J Mol Diagn
Michel C, Simon A, Witz A, Hanriot I, Dardare J, Betz M, Brun M, Gilson P, Merlin JL, Harlé A.   +9 more
europepmc   +1 more source

Population Pharmacokinetics Analysis of Talazoparib and Enzalutamide Combination Therapy for Patients With Metastatic Castration‐Resistant Prostate Cancer

The Journal of Clinical Pharmacology, EarlyView.
Abstract The poly(ADP‐ribose) polymerase inhibitor talazoparib, combined with the androgen receptor inhibitor enzalutamide is approved for patients with homologous recombination repair (HRR) gene‐mutated metastatic castration‐resistant prostate cancer (mCRPC) in the US and with mCRPC in whom chemotherapy is not clinically indicated in Europe.
Mark Hadigol, Jason H. Williams, Haihong Shi, Derek Z. Yang, Justin Hoffman, Diane D. Wang   +5 more
wiley   +1 more source

EXO1 overexpression induces homologous recombination deficiency and enhances PARP inhibitor sensitivity in ER-positive breast cancer: modulation by N4BP2L2-Mediated restoration. [PDF]

Front Cell Dev Biol
Sugiyama R, Sedukhina AS, Sato E, Yamaura A, Minagawa K, Pae S, Imai E, Chawla A, Xu Z, Chakraborty M, Gonoi S, Yamaoka J, Yudo K, Tsugawa K, Sato K.   +14 more
europepmc   +1 more source

Complete chloroplast genome of Triticum aestivum cultivar ‘Keumkang’ from Korea (Poaceae) and comparative chloroplast genomes of the members of the Triticum genus

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Bread wheat (Triticum aestivum L.) is a major global food crop, and understanding its maternal lineage and genetic diversity is essential for breeding, authentication, and evolutionary studies. Chloroplast genomes provide valuable markers for phylogenetic inference and cultivar discrimination; however, conventional plant DNA ...
Kang‐Rae Kim, Changhyun Choi, Jung Sun Kim, Myung‐Hee Kim, Hwa Jin Jung, DaHye Jeon, Jin‐Hyun Kim   +6 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source