Results 251 to 260 of about 91,698 (296)

Oncolytic Vaccinia Virus‐HSP70‐shRNA Amplifies Viral Replication, ROS/Autophagy, and Immunity to Fight Colorectal Cancer

Cancer Science, EarlyView.
OncoVV‑shHSP70, a vaccinia virus silencing HSP70, demonstrated potent antitumor efficacy in colorectal cancer cell lines, as well as in syngeneic, xenograft, and humanized mouse models. In cell lines, oncoVV‑shHSP70 promoted viral oncolysis and cytokine production through a self‑reinforcing cycle of ROS‑autophagy. In both CT26 and SW620‑humanized mouse
Rentao Yuan, Ruikang Liu, Fangying Shao, Zheqi Cai, Yingfei Fang, Kan Chen, Yanrong Zhou, Ting Ye, Gongchu Li   +8 more
wiley   +1 more source

Distinct age-related effects of homologous recombination deficiency on genomic profiling and treatment efficacy in gastric cancer. [PDF]

J Gastroenterol
Maki Y, Kono Y, Ozato T, Yamamoto H, Hirasawa A, Ennishi D, Tomida S, Toyooka S, Hamada K, Iwamuro M, Kawano S, Otsuka M.   +11 more
europepmc   +1 more source

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

Cancer Science, EarlyView.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota, Taku Naiki, Koji Hatano, Akira Yokomizo, Hiroaki Tsuchiya, Yoko Takahashi, Taku Nakayama, Masaki Yoshida, Hirotsugu Uemura   +8 more
wiley   +1 more source

Homologous recombination deficiency testing in ovarian cancer: the diagnostic experience of a referral Italian institution. [PDF]

Pathologica
Pepe F, Russo G, Cefaliello A, Lamia MR, Buonaiuto R, Crimaldi G, Scimone C, Palumbo L, Roscigno G, Parente P, De Finis MC, Fiordelisi F, Marchetti C, Giampaolino P, De Angelis C, Bianco R, Troncone G, Malapelle U.   +17 more
europepmc   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, EarlyView.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

Genomic and transcriptomic data reveal molecular differences between homologous recombination deficiency subgroups in Chinese ovarian cancer patients. [PDF]

Hum Genomics
Wang H, Zhao W, Zhou W, Wang N, Li Y, Qin K, Jia J, Wang J, Song C, Yu Y, Zhang F, Cui X, Zhao L, Luo H, Zhang Z.   +14 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data. [PDF]

Mol Oncol
Zhu R, Eason K, Chin SF, Edwards PAW, Manzano Garcia R, Moulange R, Pan JW, Teo SH, Mukherjee S, Callari M, Caldas C, Sammut SJ, Rueda OM.   +12 more
europepmc   +1 more source

Long non-coding RNAs as a biomarker for homologous recombination deficiency and parp inhibitor sensitivity in high-grade serous ovarian cancers. [PDF]

Commun Biol
Doberstein K, Panther J, Hahnen E, Richters L, Schouten PC, Harter P, Heitz F, Kommoss S, Berlit S, Tuschy B, Sütterlin M, Marmé F.   +11 more
europepmc   +1 more source

Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer. [PDF]

JCO Precis Oncol
Christinat Y, Labidi-Galy I, Ho L, Clément S, Genestie C, Sehouli J, Cinieri S, Gonzalez-Martin A, Kolovetsiou-Kreiner V, Fujiwara K, Von Gorp T, Tognon G, Hietanen S, Heinzelmann-Schwarz V, Ray-Coquard I, Pujade-Lauraine E, McKee TA.   +16 more
europepmc   +1 more source

Combination of <i>BRCA</i> deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer. [PDF]

Front Oncol
Nguyen Hoang TP, Tran NHB, Nguyen TA, Ngo MTT, Doan AD, Nguyen DQ, Tang HS, Nguyen DS, Thi CTN, Thi TTD, Nguyen HN, Giang H, Tu LN.   +12 more
europepmc   +1 more source