Results 111 to 120 of about 660,490 (319)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Higher representations and cornered Heegaard Floer homology [PDF]
, 2023 I will discuss recent work with Raphael Rouquier, focusing on a higher tensor product operation for 2-representations of Khovanov's categorification of U(gl(1|1)^+), examples of such 2-representations that arise as strands algebras in bordered and ...
Manion, Andrew
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Simplicial methods and the homology of groups. [PDF]
, 1997 PhDThis thesis generalizes the simplicial methods of defining derived functors and proves characterization theorems about them. In particular, we show that our methods also generalize an alternative way of defining derived functors, We use our ...
Modi, K
core
Infection and Drug Resistance, 2023 Yiqun Liao,1 Junjie Gong,1 Xiaoliang Yuan,2 Hongfei Lu,1 Lixia Jiang1 1Department of Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, People’s Republic of China; 2Department of Respiratory Medicine, First Affiliated ...
Liao Y, Gong J, Yuan X, Lu H, Jiang L
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Using torsion theory to compute the algebraic structure of Hochschild (co)homology [PDF]
The aim of this article is to provide explicit formulas for the cup product on the Hochschild cohomology of any nonnegatively graded connected algebra and for the cap products on the Hochschild homology of with coefficients in any graded bimodule at the ...
Herscovich, Estanislao
core +1 more source
Ultrametrics on Čech homology groups [PDF]
, 2019 This paper is devoted to introducing additional structure on Čech homology groups. First, we redefine the Čech homology groups in terms of what we have called approximative homology by using approximative sequences of cycles, just as Borsuk introduced ...
Á. Sánchez-González +5 more
core +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Skein valued curve counts, basic holomorphic disks, and HOMFLY homology [PDF]
, 2023 We describe invariant counts of holomorphic curves in a Calabi-Yau 3-fold with boundary in a Lagrangian in the skein module of that Lagrangian. We show how to turn this into concrete counts for the toric brane in the resolved conifold.
Ekholm, Tobias
core