Results 121 to 130 of about 1,015,655 (285)

Proteomic Profiling of Bacterial Extracellular Vesicles for Exploring Ovarian Cancer Biomarkers

Journal of Extracellular Biology
Extracellular vesicles (EVs) are present in body fluids and act as disease biomarkers. Emerging evidence has proven that EVs are released not only from mammalian cells but also from bacteria.
Eri Asano‐Inami, Akira Yokoi, Kosuke Yoshida, Kentaro Taki, Masami Kitagawa, Kazuhiro Suzuki, Ryosuke Uekusa, Yukari Nagao, Nobuhisa Yoshikawa, Kaoru Niimi, Yusuke Yamamoto, Hiroaki Kajiyama   +11 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Strong Homology Between Colonizing and Bloodstream Carbapenem-Resistant Acinetobacter Spp.: Implications for Empiric Antibiotic Therapy in Hematological Patients

Infection and Drug Resistance
Jia Li,1,2 Wenjing Guo,1,2 Jieru Wang,1,2 Xiaomeng Feng,1,2 Qingsong Lin,1,2,* Yizhou Zheng,1,2 Fengkui Zhang,1,2 Yingchang Mi,1,2 Xiaofan Zhu,1,2 Erlie Jiang,1,2 Zhijian Xiao,1,2 Jianxiang Wang,1,2 Sizhou Feng1,2,* 1State Key Laboratory of ...
Li J, Guo W, Wang J, Feng X, Lin Q, Zheng Y, Zhang F, Mi Y, Zhu X, Jiang E, Xiao Z, Wang J, Feng S   +12 more
doaj  

Active screening and molecular epidemiological characteristics of fecal colonization by carbapenem-resistant Enterobacterales in intensive care unit wards of a tertiary hospital in Shanghai, China

Frontiers in Public Health
BackgroundActive screening for fecal colonization by carbapenem-resistant Enterobacterales (CRE-FC) and interventions in intensive care unit (ICU) wards have become important measures to prevent carbapenem-resistant Enterobacterales (CRE) infection ...
Hui Zhang, Hui Zhang, Cong Zhou, Cong Zhou, Maosuo Xu, Maosuo Xu, Chunmei Shen, Chunmei Shen, Fang Shen, Fang Shen, Yong Lin, Yong Lin   +11 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Identification, Characterization, and Homology Analysis of a Novel Strain of the Crimean–Congo Hemorrhagic Fever Virus from Yunnan, China

Microorganisms
Wildlife serve as potential microbial reservoirs, accounting for approximately 70% of emerging infectious diseases. Crimean–Congo hemorrhagic fever virus (CCHFV), which causes Crimean–Congo hemorrhagic fever (CCHF) in humans, is a highly pathogenic tick ...
Jiale Wang, Taif Shah, Jiuxuan Zhou, Xinhua Long, Yixuan Wang, Jie Chen, Mingfei Shi, Zahir Shah, Binghui Wang, Xueshan Xia   +9 more
doaj   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Distribution characteristics of integrons and correlation analysis of antibiotic resistance in Aeromonas hydrophila

Frontiers in Cellular and Infection Microbiology
ObjectiveThis study aims to investigate the distribution of integrons in clinically isolated Aeromonas hydrophila from our hospital, as well as the correlation between antibiotic resistance, resistance genes and integrons carried by Aeromonas hydrophila.
Taotao Yang, Xuedan Qiu, Wenjun Lu, Jianqiang Xu, Yu Ye, Qiaoping Wu, Qingcao Li, Qingcao Li   +7 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Distribution characteristics of integrons and correlation analysis of antibiotic resistance in urine isolated Enterobacter cloacae

Frontiers in Cellular and Infection Microbiology
ObjectiveThis study aims to understand the distribution of integrons among Enterobacter cloacae isolated from clinical urine specimens in our hospital, as well as the molecular characteristics of the variable region resistance gene cassette of integron ...
Xuedan Qiu, Hui Zhang, Min Jiang, Qiaoping Wu, Qingcao Li, Guangliang Wu   +5 more
doaj   +1 more source