Results 51 to 60 of about 660,490 (319)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Therapeutic potential of 20-Hydroxyecdysone in pulmonary arterial hypertension: involvement of Mas receptor and PI3K–Akt pathway

Cellular & Molecular Biology Letters
Background 20-Hydroxyecdysone (20E), a natural polyhydroxylated steroid found in various edible plants, exhibits diverse pharmacological effects. Pulmonary arterial hypertension (PAH) remains challenging to treat owing to its multifactorial pathogenesis.
Tong Lu, Weiwei Jia, Yuefei Wang, Yong Ma, Chengrun Song, Fengxia Du, Hengyu Gao, Xiangguo Jin, Hong Li, Chen Liu, Haifeng Jin, Yan Lin   +11 more
doaj   +1 more source

The lipase gene family

Journal of Lipid Research, 2002
Development of the lipase gene family spans the change in science that witnessed the birth of contemporary techniques of molecular biology. Amino acid sequencing of enzymes gave way to cDNA cloning and gene organization, augmented by in vitro expression ...
Howard Wong, Michael C. Schotz
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

The Role a Concept Plays in Science - The Case of Homology [PDF]

, 2003
The present paper gives a description and philosophical analysis of the conceptual variation in the homology concept. It is argued that different homology are concepts used in evolutionary and comparative biology, in developmental biology, and in ...
Brigandt, Ingo
core  

A close look into Floer homology and applications [PDF]

, 2022
noneThis thesis is focused on Floer homology, a theory elaborated in the 1980s by Andreas Floer in order to prove the famous Arnold's conjecture about the number of fixed points of an Hamiltonian diffeomorphism.
NARDI, ALESSANDRA
core  

Phytochemical analysis and anticancer effect of Camellia oleifera bud ethanol extract in non-small cell lung cancer A549 cells

Frontiers in Pharmacology
Camellia oleifera is a medicine food homology plant widely cultivated in the Yangtze River Basin and southern China due to its camellia oil. Camellia oleifera bud and fruit exist simultaneously, and its bud is largely discarded as waste.
Jingming Niu, Xiaoyan Jia, Nian Yang, Nian Yang, Yuanquan Ran, Xia Wu, Furong Ding, Dongxin Tang, Minyi Tian, Minyi Tian, Minyi Tian   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Machine learning explainability through persistent homology [PDF]

, 2023
openIl nostro obiettivo è acquisire informazioni sulla dinamica di apprendimento delle reti neurali utilizzando uno degli strumenti principali della Topological Data Analysis: l'omologia persistente.
GRIDELLI, IVAN
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source