Results 61 to 70 of about 1,015,655 (285)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Multitarget mechanisms of the herb pair Achyranthes bidentata and Paeonia lactiflora Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration

Frontiers in Pharmacology
The herb pair Achyranthes bidentata Blume and Paeonia lactiflora Pall. (AB-PL) has demonstrated significant efficacy in the treatment of hypertensive cardiomyopathy; however, its underlying mechanisms remain unclear.
Yanyan Zhang, Yanyan Zhang, Yingwanqi Wang, Jianing Liu, Yu Zhao, Yuhui He, Peimei Yan, Shan Ren, Ying Lyu, Weiwei Jia, Yuran Sun, Song Lin, Song Lin, Yan Lin, Yan Lin   +14 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Reliable and Cost-Effective QuEChERS–UHPLC–MS/MS Method for the Simultaneous Analysis of Ten Mycotoxins in Dendrobium Officinale: A Study on Food-Medicine Homology Quality Control

Journal of Analytical Methods in Chemistry
This study developed a method for simultaneously detecting 10 mycotoxins in Dendrobium officinale using the QuEChERS technique combined with ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS). The method was optimized for
Zejun Wang, Qingcheng Wang, Fei Xu, Linhua Wang, Jingjing Liang, Qing Shen, Shunyuan Guo   +6 more
doaj   +1 more source

Chinese bayberry (Morella rubra Lour.) seed improves DSS-induced inflammatory bowel disease by inhibiting inflammation and oxidative stress

Journal of Functional Foods
This study investigated the phytochemical characteristics and first explored its anti-inflammatory action related to IBD of Chinese bayberry (Morella rubra Lour.) seed.
Dan Long, Huan Zhao, Xia Wu, Lu Jin, Yuanquan Ran, Qiong Hu, Xiaoqing Zhao, Tian Zhang, Minyi Tian   +8 more
doaj   +1 more source

Deteksi dan Evaluasi Keragaman Genetika Candidatus Liberibacter asiaticus sebagai Penyebab Penyakit Huanglongbing di Indonesia Berdasarkan Gen β-operon

Jurnal Fitopatologi Indonesia, 2017
Huanglongbing also known in Indonesia as citrus vein phloem degeneration (CVPD) is a devastating disease in citrus plantation worldwide, especially in Asia, Africa, and America.
Muhammad Rizal, Kikin Hamzah Mutaqin, Gede Suastika   +2 more
doaj   +1 more source

Homology cylinders and the acyclic closure of a free group

, 2005
We give a Dehn-Nielsen type theorem for the homology cobordism group of homology cylinders by considering its action on the acyclic closure, which was defined by Levine, of a free group. Then we construct an additive invariant of those homology cylinders
Brown, Cohn, Garoufalidis, Habegger, Heap, Hillman, Kawazumi, Le Dimet, Levine, Morita, Stallings, Takuya Sakasai   +11 more
core   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Therapeutic effect of dihydroartemisinin on Alzheimer’s disease model mice with senile macular degeneration

European Journal of Medical Research
Objectives This study focuses on the preventive and therapeutic effects of Dihydroartemisinin (DHA) on Alzheimer’s disease (AD) model mice and the effects of DHA and donepezil on amyloid β-protein deposition and autophagy in nerve cells.
Gao Han, Gong Xuewu, Zhang Meng, Wang Yuejing, Wang Yuchun, Zhang Keshuang, Yao Hongbo   +6 more
doaj   +1 more source

Reconsidering Cluster Bias in Multilevel Data: A Monte Carlo Comparison of Free and Constrained Baseline Approaches

Frontiers in Psychology, 2018
The test for item level cluster bias examines the improvement in model fit that results from freeing an item's between level residual variance from a baseline model with equal within and between level factor loadings and between level residual variances ...
Nigel Guenole
doaj   +1 more source