Results 81 to 90 of about 709,830 (296)
Integrative approaches to protein homology search [PDF]
, 2005 Alam I. Integrative approaches to protein homology search. Bielefeld (Germany): Bielefeld University; 2005.Many methods have been developed to search for homologous members of a protein family in databases, and the reliability of results and conclusions ...
Alam, Intikhab
core
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
FEBS Letters, EarlyView.Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
The 'Role' a Concept Plays in Science - The Case of Homology [PDF]
, 2001 This article tries to clarify the idea that a concept plays a certain role for a scientific field or a research program. The discussion is based on a case study of the homology concept in biology.
Brigandt, Ingo
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FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Simplicial methods and the homology of groups. [PDF]
, 1997 PhDThis thesis generalizes the simplicial methods of defining derived functors and proves characterization theorems about them. In particular, we show that our methods also generalize an alternative way of defining derived functors, We use our ...
Modi, K
core +4 more sources
Advances in Mathematics, 2010 We introduce the notion of "covering homology" of a commutative ring spectrum with respect to certain families of coverings of topological spaces. The construction of covering homology is extracted from Bokstedt, Hsiang and Madsen's topological cyclic homology.
Brun, Morten +2 more
openaire +3 more sources
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Food FrontiersTea polyphenols (TP) constitute key functional components in tea leaves, yet their instability during human digestion limits absorption. This study selected 24 representative tea varieties to establish an in vitro dynamic digestion model, investigating ...
Xinyi Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source