Results 31 to 40 of about 87,514 (244)
Frontiers in Chemistry, 2018 Diterpene synthases catalyze complex, multi-step C-C coupling reactions thereby converting the universal, aliphatic precursor geranylgeranyl diphosphate into diverse olefinic macrocylces that form the basis for the structural diversity of the diterpene ...
Max Hirte +4 more
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Sequence Alignment Using Machine Learning for Accurate Template-based Protein Structure Prediction
Bio-Protocol, 2020 Template-based modeling, the process of predicting the tertiary structure of a protein by using homologous protein structures, is useful when good templates can be available.
Shuichiro Makigaki, Takashi Ishida
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Fundamenta Mathematicae, 1984 The author developes a general type of homology theory on Top with values in the category Pro-\({\mathcal A}\) of pro-abelian groups, based on a model category \({\mathcal M}_ 0\) and a coefficient functor \(F_ 0: {\mathcal M}_ 0\to {\mathcal A}\). \({\mathcal M}_ 0\) is a small, full subcategory of Top.
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SWISS-MODEL: an automated protein homology-modeling server [PDF]
Nucleic Acids Research, 2003 SWISS-MODEL (http://swissmodel.expasy.org) is a server for automated comparative modeling of three-dimensional (3D) protein structures. It pioneered the field of automated modeling starting in 1993 and is the most widely-used free web-based automated modeling facility today. In 2002 the server computed 120 000 user requests for 3D protein models. SWISS-
Schwede, T. +3 more
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Molecules, 2015 The mitochondrial cytochrome P450 enzymes inhibitor steroid 11β-hydroxylase (CYP11B1) can decrease the production of cortisol. Therefore, these inhibitors have an effect in the treatment of Cushing’s syndrome.
Rui Yu +7 more
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The Homology Modeling and Docking Investigation of Human Cathepsin B [PDF]
International Journal of Medical Toxicology and Forensic Medicine, 2020 Background: Cathepsin B comprises a group of lysosomal cysteine proteases belonging to the Papain family; it has an intracellular function in the process of protein catabolism, antigen processing in the immune response, and Alzheimer’s disease.
Afshin Khara +2 more
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LoopIng: A template-based tool for predicting the structure of protein loops [PDF]
, 2015 MOTIVATION: Predicting the structure of protein loops is very challenging, mainly because they are not necessarily subject to strong evolutionary pressure.
ABDEL MESSIH, MARIO ALFY FAHMY +2 more
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Using multiple templates to improve quality of homology models in automated homology modeling [PDF]
Protein Science, 2008 AbstractWhen researchers build high‐quality models of protein structure from sequence homology, it is today common to use several alternative target‐template alignments. Several methods can, at least in theory, utilize information from multiple templates, and many examples of improved model quality have been reported.
Per, Larsson +3 more
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Structure Prediction and Functional Characterization of ERG Proteins Involved in Ergosterol Biosynthetic Pathway of Candida albicans [PDF]
, 2011 The ERG proteins and enzymes of the ergosterol biosynthetic pathway has been the subject of intensive investigation as a target for several classes of antifungal agents used to treat C. albicans infection. Over the past few decades, a number of drugs and
Ashok Sharma +2 more
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Structural Modeling and Validation of Rep protein of Begomovirus Strains (TLCBV and TYLCTHV) [PDF]
, 2011 Homology modeling involves taking a known sequence with an unknown structure and mapping it against a known structure of one or several similar (homologous) proteins.
Rajarshi Kumar Gaur +2 more
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