Topology Applied to Machine Learning: From Global to Local
Frontiers in Artificial Intelligence, 2021 Through the use of examples, we explain one way in which applied topology has evolved since the birth of persistent homology in the early 2000s. The first applications of topology to data emphasized the global shape of a dataset, such as the three-circle
Henry Adams, Michael Moy
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Cloning, Expression, Sequence Analysis and Homology Modeling of the Prolyl Endoprotease from Eurygaster integriceps Puton [PDF]
, 2014 Eurygaster integriceps Puton, commonly known as sunn pest, is a major pest of wheat in Northern Africa, the Middle East and Eastern Europe. This insect injects a prolyl endoprotease into the wheat, destroying the gluten.
Clack, Beatrice A. +5 more
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A comparative structural analysis of sepiapterin reductase from Drosophila by homology modeling
Pteridines, 2015 Sepiapterin reductase (SR) catalyzes the final steps of BH4 biosynthesis. Previously, a gene encoding SR has been cloned and characterized from a Drosophila cDNA library in vitro.
Kim Kiyoung +2 more
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Structural prediction and in silico physicochemical characterization for mouse caltrin I and bovine caltrin proteins [PDF]
, 2016 It is known that caltrin (calcium transport inhibitor) protein binds to sperm cells during ejaculation and inhibits extracellular Ca2+ uptake. Although the sequence and some biological features of mouse caltrin I and bovine caltrin are known, their ...
Coronel, Carlos Enrique +2 more
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Homology modelling by distance geometry
Folding and Design, 1996 Unknown protein structures can be predicted from known structures (the scaffolds) with sequences sufficiently homologous to that of the target, based on the observation that similar sequences usually adopt the same fold. When structural equivalences between residues in the scaffold and target proteins are expressed in terms of conserved interatomic ...
Aszódi, Andrés, Taylor, William R.
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Homotopy Algebra Structures on Twisted Tensor Products and String Topology Operations
, 2011 Given a $C_\infty$ coalgebra $C_*$, a strict dg Hopf algebra $H_*$, and a twisting cochain $\tau:C_* \rightarrow H_*$ such that $Im(\tau) \subset Prim(H_*)$, we describe a procedure for obtaining an $A_\infty$ coalgebra on $C_* \otimes H_*$.
Miller, Micah
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A combined computational-experimental approach to define the structural origin of antibody recognition of sialyl-Tn, a tumor-associated carbohydrate antigen. [PDF]
, 2018 Anti-carbohydrate monoclonal antibodies (mAbs) hold great promise as cancer therapeutics and diagnostics. However, their specificity can be mixed, and detailed characterization is problematic, because antibody-glycan complexes are challenging to ...
Amon, Ron +12 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Homology in Abelian Lattice Models
Letters in Mathematical Physics, 1997 latex, 10 ...
Rakowski, Mark, Sen, Siddhartha
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Historical contingency and entrenchment in protein evolution under purifying selection [PDF]
, 2014 The fitness contribution of an allele at one genetic site may depend on alleles at other sites, a phenomenon known as epistasis. Epistasis can profoundly influence the process of evolution in populations under selection, and can shape the course of ...
McCandlish, David M. +2 more
core +2 more sources