Results 191 to 200 of about 17,772 (214)

Optical enantiomorphs of homoserine and homocystine

Archives of Biochemistry and Biophysics, 1953
Abstract Chloroacetyl- dl -homoserine lactone was synthesized. After opening the ring at pH 8, and treating with hog kidney acylase I, dl -homoserine ([α]D = −8.8 ° in water and +18.3 ° in 2 N HCl) was obtained in 72% yield. From the mother liquor, chloroacetyl- d -homoserine was separated, yielding on HCl hydrolysis the lactone of d -homoserine ...
Jesse P. Greenstein, Sanford M. Birnbaum
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Biosynthesis of threonine from homoserine in pea seedlings: I. Homoserine kinase.

Plant Science Letters, 1978
Summary Homoserine kinase was partially purified from green shots of 2-week-old pea ( Pisum sativum L. cv. Pillert Fenomen) seedlings. The enzyme had an absolute requirement for both divalent (mg 2+ and Mn 2+ ) and monovalent (K + ) cations. The K m values of homoserine (6.7 mM) and ATp (2.7 mM) were much higher than for the enzyme from barley ...
Aarnes Halvor, Sven Erik Rognes, A˚ge Thoen   +2 more
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A Convenient Resolution of (±)-Homoserine to Afford Carbobenzoxy-D-Homoserine and D-Homoserine

Preparative Biochemistry and Biotechnology, 1981
Abstract D-Homoserine is an amino acid that has recently been found t o occur in the Nocardicin antibiotics. Herein we describe a simple resolution of the racemic material to afford carbobenzoxy-D-homo- serine via the L-tyrosinehydrazide salt and hence also D-homoserine itself.
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Synthesis and rearangement of homoserine derivatives

Tetrahedron, 1988
AbstractThe reduction of the aspartic acid derivative (Ia) with diisobutyl‐AlH affords the L‐homoserine lactone (II); (Ib) or (Ic) likewise give (II) on reduction.
Jack E. Baldwin, A. Flinn, M. North
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Decreased homoserine levels in metabolic syndrome

Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2020
The pathogenesis Metabolic Syndrome (MetS), a common global problem, remains to be elucidated. As part of our exploratory metabolomics research we determined if homoserine levels are an early biomarker of nascent MetS.An exploratory study involving 28 patients with nascent MetS and 20 matched controls.
Ajay Patel, Lillian Abdelmalek, Austin Thompson, Ishwarlal Jialal   +3 more
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Synthesis of some homoserine derivatives [PDF]

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1967
1. Some new homoserine derivatives, substituted on the hydroxy, amino and carboxyl groups, were obtained. 2. The N-phosphorylation of homoserine cyclohexylamide was accomplished using O-phenyl-N-bis(β-chloroethyl) phosphoramidic chloride.
L. P. Parshina, I. L. Knunyants, N. B. Kaz'mina, O. V. Kil'disheva   +3 more
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ChemInform Abstract: Synthesis of a New Constrained Homoserine.

ChemInform, 1995
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Miguel A. Fernández-Recio, Alberto Avenoza, Carlos Cativiela, Jesús M. Peregrina   +3 more
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Catalytic Mechanism of Fungal Homoserine Transacetylase

Biochemistry, 2005
Homoserine transacetylase is a required catalyst in the biochemical pathway that metabolizes Asp to Met in fungi. The enzyme from the yeast Schizosaccharomyces pombe activates the hydroxyl group of L-homoserine by acetylation from acetyl coenzyme A. This enzyme is unique to fungi and some bacteria and presents an important new target for drug discovery.
Gerard D. Wright, Ishac Nazi
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Properties of homoserine dehydrogenase in a thermophilic bacterium

Biochimica et Biophysica Acta (BBA) - Enzymology, 1973
Abstract A highly thermostable homoserine dehydrogenase ( l -homoserine NADP+-oxidoreductase, EC 1.1.1.3) from a thermophilic organism is described. Maximal activity was obtained to 70†C and at a pH of 9.8; K+-was essential for activity. The enzyme was feedback inhibited by l -threonine, the inhibition being of a competitive type.
B.Z. Cavari, Nathan Grossowicz
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Homoserine inhibition of in vitro sickling of erythrocytes

Experimental and Molecular Pathology, 1975
Abstract Homoserine blocks and reverses significantly the sickling of sickle cell erythrocytes in vitro at 0.05–0.1 M concentrations and delays the gel formation of hemoglobin S at 37°C. The effect of homoserine on the inhibition of erythrocyte sickling is reversible when the cell suspension is diluted extensively with buffer before deoxygenation.
Georges Benjamin, Soo-Sang Kang
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