Results 1 to 10 of about 67,647 (157)

AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data

Nature Communications, 2021
Homozygosity mapping is a useful tool for identifying candidate mutations in recessive conditions, however application to next generation sequencing data has been sub-optimal.
Mathieu Quinodoz, Virginie G. Peter, Nicola Bedoni, Béryl Royer Bertrand, Katarina Cisarova, Arash Salmaninejad, Neda Sepahi, Raquel Rodrigues, Mehran Piran, Majid Mojarrad, Alireza Pasdar, Ali Ghanbari Asad, Ana Berta Sousa, Luisa Coutinho Santos, Andrea Superti-Furga, Carlo Rivolta   +15 more
doaj   +2 more sources

Characterizing genome-wide changes associated with inbreeding tolerance in cranberry: insights into homozygosity and heterozygosity [PDF]

Frontiers in Plant Science
The American cranberry (Vaccinium macrocarpon) is an important native North American fruit. Cranberry is a self-fertile woody perennial. As part of an ongoing breeding and genetics program, inbred lines have been developed to help understand the effects ...
Derek Wang, Joseph Kawash, James Polashock, Iman Dehzangi, Iman Dehzangi, Iman Dehzangi   +5 more
doaj   +2 more sources

Genome-Wide Characterization of Selection Signatures and Runs of Homozygosity in Ugandan Goat Breeds

Frontiers in Genetics, 2018
Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation ...
Robert B. Onzima, Robert B. Onzima, Maulik R. Upadhyay, Maulik R. Upadhyay, Harmen P. Doekes, Luiz. F. Brito, Mirte Bosse, Egbert Kanis, Martien A. M. Groenen, Richard P. M. A. Crooijmans   +9 more
doaj   +2 more sources

Prognostic value of HLA-I homozygosity in patients with non-small cell lung cancer treated with single agent immunotherapy

Journal for ImmunoTherapy of Cancer, 2020
Background We aimed to assess the impact of genomic human leukocyte antigen (HLA)-I/II homozygosity on the survival benefit of patients with unresectable locally advanced, metastatic non-small lung cancer treated by single-agent programmed cell death ...
Mark Watson, Michael Millward, Samantha Bowyer, Afaf Abed, Leslie Calapre, Johnny Lo, Suzana Correia, Abha Chopra, Muhammad Adnan Khattak, Elin Solomonovna Gray   +9 more
doaj   +2 more sources

A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types

Animals, 2019
Simple Summary Runs of homozygosity (ROH) regions are known to be common in the genomes of cattle and have become a subject of interest of various research in recent years.
Artur Gurgul, Monika Bugno-Poniewierska, Igor Jasielczuk   +2 more
exaly   +2 more sources

Genome‐Wide Homozygosity Predicts Inbreeding Depression in the Hihi/Stitchbird (Notiomystis cincta) Better Than Realised Load [PDF]

Evolutionary Applications
Population declines result in increasingly small populations, which often experience an increase in inbreeding. Inbreeding may be negatively associated with fitness traits like survival and reproduction, that is, inbreeding depression, and is therefore ...
Hui Zhen Tan, Katarina C. Stuart, Joseph Guhlin, Tram Vi, Selina Patel, Laura Duntsch, John G. Ewen, Patricia Brekke, Anna W. Santure   +8 more
doaj   +2 more sources

Genome-wide patterns of homozygosity provide clues about the population history and adaptation of goats

Genetics Selection Evolution, 2018
Background Patterns of homozygosity can be influenced by several factors, such as demography, recombination, and selection. Using the goat SNP50 BeadChip, we genotyped 3171 goats belonging to 117 populations with a worldwide distribution.
Francesca Bertolini, Tainã Figueiredo Cardoso, Gabriele Marras, Ezequiel L. Nicolazzi, Max F. Rothschild, Marcel Amills, the AdaptMap consortium   +6 more
doaj   +2 more sources

Genomic inbreeding estimation in small populations: evaluation of runs of homozygosity in three local dairy cattle breeds

Animal, 2016
In the local breeds with small population size, one of the most important problems is the increase of inbreeding coefficient (F). High levels of inbreeding lead to reduced genetic diversity and inbreeding depression.
Salvatore Mastrangelo, Luca Fontanesi, Maria Teresa Sardina   +2 more
exaly   +2 more sources

Patterns of homozygosity in insular and continental goat breeds

Genetics Selection Evolution, 2018
Background Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 ...
Taina F. Cardoso, Marcel Amills, Francesca Bertolini, Max Rothschild, Gabriele Marras, Geert Boink, Jordi Jordana, Juan Capote, Sean Carolan, Jón H. Hallsson, Juha Kantanen, Agueda Pons, Johannes A. Lenstra, The AdaptMap Consortium   +13 more
doaj   +2 more sources

Organ allocation and transplant equity in Brazil: the hidden burden of HLA homozygosity and hypersensitization [PDF]

Brazilian Journal of Nephrology
Introduction: Kidney transplantation remains the most cost-effective treatment for end-stage renal disease (ESRD); however, persistent organ scarcity and immunological barriers contribute to prolonged waiting times and inequitable access. Human leukocyte
Augusto Cesar Soares dos Santos Júnior, Evaldo Nascimento, Aline Regina da Cruz, Bernardo Vilela Nascimento, Raquel Aparecida Fabreti-Oliveira   +4 more
doaj   +5 more sources