Results 11 to 20 of about 80,852 (330)

Pitfalls in Homozygosity Mapping [PDF]

The American Journal of Human Genetics, 2000
There is much interest in use of identity-by-descent (IBD) methods to map genes, both in Mendelian and in complex disorders. Homozygosity mapping provides a rapid means of mapping autosomal recessive genes in consanguineous families by identifying chromosomal regions that show homozygous IBD segments in pooled samples. In this report, we point out some
Miano MG, Jacobson SG, Carothers A, Hanson I, Teague P, Lovell J, Cideciyan AV, Haider N, Stone EM, Sheffield VC, Wright AF   +10 more
core   +7 more sources

Symposium review: Exploiting homozygosity in the era of genomics-Selection, inbreeding, and mating programs. [PDF]

Journal of Dairy Science, 2020
The advent of genomic selection paved the way for an unprecedented acceleration in genetic progress. The increased ability to select superior individuals has been coupled with a drastic reduction in the generation interval for most dairy populations ...
C. Maltecca, F. Tiezzi, J. Cole, C. Baes
semanticscholar   +3 more sources

Runs of homozygosity in European populations. [PDF]

The American Journal of Human Genetics, 2008
Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of ...
R. McQuillan, A. Leutenegger, R. Abdelrahman, C. Franklin, M. Peričić, Lovorka Barac-Lauc, N. Smolej-Narančić, B. Janićijević, O. Polašek, A. Tenesa, A. Macleod, S. Farrington, P. Rudan, C. Hayward, V. Vitart, I. Rudan, S. Wild, M. Dunlop, A. Wright, H. Campbell, James F. Wilson   +20 more
semanticscholar   +7 more sources

Symposium review: The genomic architecture of inbreeding: How homozygosity affects health and performance. [PDF]

Journal of Dairy Science, 2019
Inbreeding depression is a growing concern in livestock because it can detrimentally affect animal fitness, health, and production levels. Genomic information can be used to more effectively capture variance in Mendelian sampling, thereby enabling more ...
C. Baes, B. Makanjuola, F. Miglior, G. Marras, J. Howard, A. Fleming, C. Maltecca   +6 more
semanticscholar   +2 more sources

Homozygosity Mapping

, 2006
The mapping of genes involved in rare recessive disorders in large outbred population is often a difficult task because of the lack of families with multiple affected individuals. Homozygosity mapping is an efficient gene mapping method applicable to rare recessive disorders in inbred populations.
Génin, Emmanuelle, Todorov, Alexandre
openaire   +4 more sources

Extended homozygosity is not usually due to cytogenetic abnormality [PDF]

BMC Genetics, 2007
Background Previous studies have reported frequent stretches of homozygosity in human subjects but have failed to clarify whether these are due to cytogenetic abnormalities or to autozygosity.
Curtis David
doaj   +2 more sources

Runs of Homozygosity

Definitions, 2019
(ROH). Contiguous regions of the genome where an individual is homozygous across all sites. T his arises if the haplotypes transmitted from the mother and father are identical, having in turn been inherited from a common ancestor at some point in the ...
Francisco C. Ceballos
semanticscholar   +2 more sources

Runs of Homozygosity and Inferences in Wild Populations

Molecular Ecology
Long homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here, we review some
Aaron B. A. Shafer, Marty Kardos
semanticscholar   +3 more sources

Long runs of homozygosity are associated with Alzheimer’s disease

Translational Psychiatry, 2021
Long runs of homozygosity (ROH) are contiguous stretches of homozygous genotypes, which are a footprint of inbreeding and recessive inheritance. The presence of recessive loci is suggested for Alzheimer’s disease (AD); however, their search has been ...
Sonia Moreno-Grau, Maria Victoria Fernández, Itziar de Rojas, Pablo Garcia-González, Isabel Hernández, Fabiana Farias, John P. Budde, Inés Quintela, Laura Madrid, Antonio González-Pérez, Laura Montrreal, Emilio Alarcón-Martín, Montserrat Alegret, Olalla Maroñas, Juan Antonio Pineda, Juan Macías, The GR@ACE study group, DEGESCO consortium, Marta Marquié, Sergi Valero, Alba Benaque, Jordi Clarimón, Maria Jesus Bullido, Guillermo García-Ribas, Pau Pástor, Pascual Sánchez-Juan, Victoria Álvarez, Gerard Piñol-Ripoll, Jose María García-Alberca, José Luis Royo, Emilio Franco-Macías, Pablo Mir, Miguel Calero, Miguel Medina, Alberto Rábano, Jesús Ávila, Carmen Antúnez, Luis Miguel Real, Adelina Orellana, Ángel Carracedo, María Eugenia Sáez, Lluís Tárraga, Mercè Boada, Carlos Cruchaga, Agustín Ruiz, for the Alzheimer’s Disease Neuroimaging Initiative   +45 more
doaj   +2 more sources

Multi-locus homozygosity promotes actuarial senescence in a wild mammal. [PDF]

, 2023
Genome-wide homozygosity, caused for example by inbreeding, is expected to have deleterious effects on survival and/or reproduction. Evolutionary theory predicts that any fitness costs are likely to be detected in late life because natural selection will
DW Hudson (21921122), R Delahay (21828308), TJ McKinley (21855602), CH Benton (21854513), RA McDonald (16310592), DJ Hodgson (14460636)   +5 more
core   +6 more sources