Results 11 to 20 of about 66,200 (304)
AutoMap is a high performance homozygosity mapping tool using next-generation sequencing data
Nature Communications, 2021 Homozygosity mapping is a useful tool for identifying candidate mutations in recessive conditions, however application to next generation sequencing data has been sub-optimal.
Mathieu Quinodoz +15 more
doaj +2 more sources
Runs of Homozygosity in European Populations [PDF]
The American Journal of Human Genetics, 2008 Estimating individual genome-wide autozygosity is important both in the identification of recessive disease variants via homozygosity mapping and in the investigation of the effects of genome-wide homozygosity on traits of biomedical importance. Approaches have tended to involve either single-point estimates or rather complex multipoint methods of ...
McQuillan, Ruth +20 more
openaire +5 more sources
Genome-Wide Characterization of Selection Signatures and Runs of Homozygosity in Ugandan Goat Breeds
Frontiers in Genetics, 2018 Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation ...
Robert B. Onzima +9 more
doaj +2 more sources
Journal for ImmunoTherapy of Cancer, 2020 Background We aimed to assess the impact of genomic human leukocyte antigen (HLA)-I/II homozygosity on the survival benefit of patients with unresectable locally advanced, metastatic non-small lung cancer treated by single-agent programmed cell death ...
Mark Watson +9 more
doaj +2 more sources
Runs of homozygosity and inferences in wild populations
Molecular EcologyLong homozygous chromosome segments are known as runs of homozygosity (ROH); these reflect patterns of identity by descent and can be used to measure individual inbreeding, map recessive traits, and reconstruct demographic histories. Here we review some key considerations with ROH detection and the inferences pertaining to inbreeding and demographic ...
Aaron B. A. Shafer, Marty Kardos
openaire +3 more sources
Genetics Selection Evolution, 2018 Background Patterns of homozygosity can be influenced by several factors, such as demography, recombination, and selection. Using the goat SNP50 BeadChip, we genotyped 3171 goats belonging to 117 populations with a worldwide distribution.
Francesca Bertolini +6 more
doaj +2 more sources
Patterns of homozygosity in insular and continental goat breeds
Genetics Selection Evolution, 2018 Background Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 ...
Taina F. Cardoso +13 more
doaj +2 more sources
Parental relatedness through time revealed by runs of homozygosity in ancient DNA
Nature Communications, 2021 Parental relatedness of present-day humans varies substantially across the globe, but little is known about the past. Here we analyze ancient DNA, leveraging that parental relatedness leaves genomic traces in the form of runs of homozygosity.
Harald Ringbauer +2 more
semanticscholar +1 more source
Runs of homozygosity in killer whale genomes provide a global record of demographic histories
Molecular Ecology, 2021 Runs of homozygosity (ROH) occur when offspring inherit haplotypes that are identical by descent from each parent. Length distributions of ROH are informative about population history; specifically, the probability of inbreeding mediated by mating system
A. Foote +33 more
semanticscholar +1 more source
Runs of Homozygosity Revealed Reproductive Traits of Hu Sheep
Genes, 2022 Hu sheep, a famous breed in the Taihu Basin, has the advantages of non-seasonal estrus, multiple fetuses, coarse feeding tolerance, and suitability for house feeding.
Yuzhe Li +6 more
semanticscholar +1 more source