Results 81 to 90 of about 3,048,991 (107)
Hopantenic Acid: Perspectives for Its Use in Psychiatry
Consilium Medicum, 2018 Yu.V. Bykov, R.A. Bekker
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Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2015 To evaluate the efficacy and safety of D-, L-hopantenic acid (pantogam active) on cognitive and anxiety disorders in patients with arterial hypertension.Autors selected 80 inpatients of a cardiology department with the verified diagnosis of hypertension and comorbid cognitive and anxiety disorders (50 patients in the main group, 30 patients in the ...
Anatoly B. Smulevich, B A Volel
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Hopantenic acid beta-glucoside as a new urinary metabolite of calcium hopantenate in dogs.
Drug Metabolism and Disposition, 1986The metabolism of calcium hopantenate (HOPA) was studied in beagle dogs. After oral administration of 14C-labeled HOPA, 25.5% of the administered radioactivity was excreted in the urine within 24 hr, mostly in the form of unchanged drug. The only metabolite, accounting for 4.2% of the radioactivity in the urine, was isolated by HPLC. The metabolite was
K, Nakano +4 more
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Application of Photogenerated Titrants for Determining Hopantenic Acid in a Solid Dosage Form
Pharmaceutical Chemistry JournalE V Turusova
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Journal of Chromatography B, Biomedical Sciences and Applications, 1991
The chiral separation and simultaneous determination of D- and L-pantothenic acids and D- and L-hopantenic acids in rat plasma using gas chromatography-mass fragmentography are described. The method is based on deproteinization by ion-exchange resin, extraction with ethyl acetate under acidic conditions, and derivatization to form several interesting ...
K Banno
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The chiral separation and simultaneous determination of D- and L-pantothenic acids and D- and L-hopantenic acids in rat plasma using gas chromatography-mass fragmentography are described. The method is based on deproteinization by ion-exchange resin, extraction with ethyl acetate under acidic conditions, and derivatization to form several interesting ...
K Banno
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Acta Chromatographica, 2011 Summary A reliable and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) with ultraviolet (UV) detection method was developed and validated for the quantification of hopantenic acid in human plasma. Hopantenic acid, with protocatechuic acid as the internal standard (IS), was extracted from plasma samples using a liquid-liquid ...
Vera Kosman +2 more
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Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2015
Hopantenic acid is a well-known nootropic drug similar in its chemical structure to pantothenic acid (vitamin B5). Neurotropic effects of hopantenic acid act through binding with delta- and kappa opioid receptors, modulation of acetylcholine secretion and relationship with dopamine receptors.
Konstantin Rudakov +2 more
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Hopantenic acid is a well-known nootropic drug similar in its chemical structure to pantothenic acid (vitamin B5). Neurotropic effects of hopantenic acid act through binding with delta- and kappa opioid receptors, modulation of acetylcholine secretion and relationship with dopamine receptors.
Konstantin Rudakov +2 more
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Anxiety and Depressive Disorders in Cardiology Practice. Possibilities of Using D,L-Hopantenic Acid
Consilium Medicum, 2018 O.D. Ostroumova +3 more
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Abnormal fatty acid metabolism in patients in hopantenate therapy during clinical episodes
Journal of Chromatography B: Biomedical Sciences and Applications, 1991Calcium 4-(2,4-dihydroxy-3,3-dimethylbutyramido)butyrate hemihydrate (hopantenate), a cerebral metabolic enhancer used in Japan since 1978, is a homologue of pantothenic acid. Using mass spectrometry, we found urinary excretion of 4-hydroxydodecanedioic acid, 4-hydroxytetradecanedioic acid and a series of 2-hydroxydicarboxylic acids (C8-C14), in ...
M, Matsumoto +4 more
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Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 2016
To evaluate the efficacy and tolerability of rac-hopantenic acid (pantogam activ) in patients with mixed anxiety-depressive disorder and anxiety-depressive disorder with chronic cerebral ischemia.A total of 50 patients were examined (30 patients in the main group, 20 patients in the control one).
Ksenia Zakharova
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To evaluate the efficacy and tolerability of rac-hopantenic acid (pantogam activ) in patients with mixed anxiety-depressive disorder and anxiety-depressive disorder with chronic cerebral ischemia.A total of 50 patients were examined (30 patients in the main group, 20 patients in the control one).
Ksenia Zakharova
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