Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing [PDF]
Bioinorganic Chemistry and ApplicationsAlzheimer’s disease (AD) is the most common neurodegenerative disorder associated with cognitive decline and loss of memory. It is postulated that the generation of reactive oxygen species (ROS) in Fenton-like reaction connected with Cu(II)/Cu(I) redox ...
Marianna Flora Tomasello +6 more
doaj +4 more sources
Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis [PDF]
Brain Sciences, 2021 The pharmacological induction and activation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), a key regulator of ischemic brain tolerance, is a promising direction in neuroprotective therapy.
Fatima M. Shakova +4 more
doaj +4 more sources
ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke [PDF]
BiomedicinesBackground: Ischemic stroke results from a disruption of cerebral blood flow. Adrenocorticotropic hormone (ACTH) serves as the basis for the creation of synthetic peptides as neuroprotective agents for stroke therapy.
Ivan B. Filippenkov +8 more
doaj +3 more sources
Semi-Mechanistic PK/PD Modeling of Platelets and Spleen Volume With Navitoclax in Combination With Ruxolitinib in Patients With Myelofibrosis. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Navitoclax, an oral small molecule BCL‐XL/BCL‐2 inhibitor evaluated in myelofibrosis, was assessed through integrated PK/PD modeling to guide starting dose and dose‐reduction decisions when combined with ruxolitinib. An integrated sequential PK/PD model was developed to describe the relationships between navitoclax and ruxolitinib exposure ...
Polepally AR +7 more
europepmc +2 more sources
Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research) [PDF]
Research Results in Pharmacology, 2020 Introduction: Tuberculosis is a widely spread infection. While treating patients for it, they are given simultaneously and for a long period 5-6 antibacterial drugs, which are, as a rule, bad for the liver.
Vladimir N. Fedorov +5 more
doaj +5 more sources
Therapeutic peptides in gerontology: mechanisms and applications for healthy aging [PDF]
Frontiers in AgingBackgroundPeptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.ObjectiveTo ...
Volodymyr Mavrych +2 more
doaj +2 more sources
Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats) [version 2; peer review: 2 approved, 1 not approved] [PDF]
F1000Research, 2023 Background Spinal cord injury (SCI) is a damage to the spinal cord caused mainly by trauma resulting in major motor, sensory and autonomic dysfunctions. Its final neurological outcome is determined by both primary and secondary injury processes.
I Ketut Sudiana +6 more
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Protein-Driven Copper Redox Regulation: Uncovering the Role of Disulphide Bonds and Allosteric Modulation. [PDF]
Angew Chem Int Ed EnglCopper binding triggers structural changes that expose a reactive disulphide bridge, enabling intrinsic Cu(II) reduction in folded proteins. SAXS, XAS, and QM/MM simulations reveal how globular proteins such as HSA and SOD1 employ disulphide‐mediated dynamics to modulate site accessibility and control copper redox chemistry.
Sternke-Hoffmann R +9 more
europepmc +2 more sources
Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology [PDF]
Beilstein Journal of Nanotechnology, 2017 Although the formation of β-amyloid (Aβ) fibrils in neuronal tissues is a hallmark of Alzheimer disease (AD), small-sized Aβ oligomers rather than mature fibrils have been identified as the most neurotoxic species. Therefore, the design of new inhibitors,
Clelia Galati +6 more
doaj +2 more sources
Study of the role of neurotrophic factors in the regulation of regeneration processes in damaged somatic nerves under the action of semax peptide preparation [PDF]
Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023 The content of neurotrophic factors in damaged somatic nerves under the action of the drug «Semax» was studied and their role in the regulation of regenerative processes in injured nerve conductors was established.
Parchaykina, Marina V. +5 more
doaj +1 more source