Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis [PDF]
Brain Sciences, 2021 The pharmacological induction and activation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), a key regulator of ischemic brain tolerance, is a promising direction in neuroprotective therapy.
Fatima M. Shakova +4 more
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Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing [PDF]
Bioinorganic Chemistry and ApplicationsAlzheimer’s disease (AD) is the most common neurodegenerative disorder associated with cognitive decline and loss of memory. It is postulated that the generation of reactive oxygen species (ROS) in Fenton-like reaction connected with Cu(II)/Cu(I) redox ...
Marianna Flora Tomasello +6 more
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Effect of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury models (male Sprague Dawley rats) [version 2; peer review: 2 approved, 1 not approved] [PDF]
F1000Research, 2023 Background Spinal cord injury (SCI) is a damage to the spinal cord caused mainly by trauma resulting in major motor, sensory and autonomic dysfunctions. Its final neurological outcome is determined by both primary and secondary injury processes.
I Ketut Sudiana +6 more
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Therapeutic peptides in gerontology: mechanisms and applications for healthy aging [PDF]
Frontiers in AgingBackgroundPeptide therapeutics represent an emerging frontier in gerontological medicine, targeting fundamental hallmarks of aging including metabolic dysfunction, telomere attrition, tissue repair impairment, and hormonal decline.ObjectiveTo ...
Volodymyr Mavrych +2 more
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ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke [PDF]
BiomedicinesBackground: Ischemic stroke results from a disruption of cerebral blood flow. Adrenocorticotropic hormone (ACTH) serves as the basis for the creation of synthetic peptides as neuroprotective agents for stroke therapy.
Ivan B. Filippenkov +8 more
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Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology [PDF]
Beilstein Journal of Nanotechnology, 2017 Although the formation of β-amyloid (Aβ) fibrils in neuronal tissues is a hallmark of Alzheimer disease (AD), small-sized Aβ oligomers rather than mature fibrils have been identified as the most neurotoxic species. Therefore, the design of new inhibitors,
Clelia Galati +6 more
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Study of the role of neurotrophic factors in the regulation of regeneration processes in damaged somatic nerves under the action of semax peptide preparation [PDF]
Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология, 2023 The content of neurotrophic factors in damaged somatic nerves under the action of the drug «Semax» was studied and their role in the regulation of regenerative processes in injured nerve conductors was established.
Parchaykina, Marina V. +5 more
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Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research) [PDF]
Research Results in Pharmacology, 2020 Introduction: Tuberculosis is a widely spread infection. While treating patients for it, they are given simultaneously and for a long period 5-6 antibacterial drugs, which are, as a rule, bad for the liver.
Vladimir N. Fedorov +5 more
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Selank and semax as potential hepatoprotectors in medical treatment of tuberculosis [PDF]
Research Results in Pharmacology, 2019 Introduction: Drug-induced hepatitis is common in clinical practice. This problem is particularly relevant in the treatment of tuberculous infection, because for this purpose, up to 5–6 hepatotoxic drugs are used simultaneously for a long time, which ...
Alexey K. Petrovsky +5 more
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Сибирский научный медицинский журнал, 2023 In modern physiology, the priority direction is the study of the influence of various types of stress, leading, as a rule, to the development of depressive states, on the physiological systems of the body.
V. Kh. Murtalieva +4 more
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