Results 1 to 10 of about 249 (164)

Theoretical insights into the antiradical activity and copper-catalysed oxidative damage of mexidol in the physiological environment [PDF]

Royal Society Open Science, 2022
Mexidol (MD, 2-ethyl-6-methyl-3-hydroxypyridine) is a registered therapeutic agent for the treatment of anxiety disorders. The chemical structure suggests that MD may also act as an antioxidant. In this study, the hydroperoxyl radical scavenging activity
Nguyen Thi Hoa, Mai Van Bay, Adam Mechler   +2 more
exaly   +4 more sources

Geriatric information analysis of the molecular properties of mexidole

Неврология, нейропсихиатрия, психосоматика, 2017
Objective: by using the pharmacoinformation profiling, to comprehensively assess all possible effects of the molecules of mexidol, choline alfoscerate, piracetam, glycine, and semax in accordance with the anatomical therapeutic and chemical (ATC ...
O. A. Gromova, I. Yu. Torshin, L. E. Fedotova   +2 more
doaj   +3 more sources

Comparative chemoreactome analysis of mexidol

Фармакокинетика и Фармакодинамика, 2016
The paper presents the results of chemorectome modeling of the pharmacological effects of ethylmethylhydroxypyridine succinate (mexidol) as compared to control molecules (choline alfoscerate, piracetam, glycine, semax). Chemoreactome analysis showed that
I. J. Torshin, O. A. Gromova, I. S. Sardaryan, L. E. Fedotova, V. A. Semenov   +4 more
doaj   +1 more source

Possibilities of multimodal neuroprotection in patients with chronic cerebral ischemia on the background of arterial hypertension and atherosclerosis

Неврология, нейропсихиатрия, психосоматика, 2023
hronic cerebrovascular pathology is manifested by a combination of cognitive, emotional and autonomic disorders. Correct and timely assessment and accurate diagnosis of emotional and autonomic disorders and their timely correction are important, among ...
I. A. Gribacheva, T. F. Popova, E. V. Petrova, A. V. Zvonkova   +3 more
doaj   +1 more source

Safety of Mexidol® (ethylmethylhydroxypyridine succinate) in adult patients of different age groups

Неврология, нейропсихиатрия, психосоматика, 2022
To reduce the risk of developing adverse events (AEs) and increase the adherence of elderly patients to treatment, it is recommended to limit maximally the total number of prescribed drugs (DR), using one drug for the treatment of two or more pathologies
E. A. Ushkalova, S. K. Zyryanov, O. I. Butranova   +2 more
doaj   +1 more source

THE IMPORTANCE OF A PHOTOSENSITIZER BLEACHING REGISTRATION FOR THE EVALUATION OF MECHANISM OF PREPARATION ACTION ON THE PHOTO-INDUCED HEMOLYSIS

Biomedical Photonics, 2017
The influence of three pharmaceutical preparations on photo-induced lysis (irradiation with light-emitting diode of 653 nm) of human erythrocytes in the presence of photosensitizer radachlorin and also on the quantum yield of radachlorin photobleaching ...
L. V. Galebskaya, I. L. Solovtsova, E. B. Miroshnikova, I. A. Mikhailova, M. E. Sushkin, A. V. Razumny, A. V. Babina, V. A. Fomina   +7 more
doaj   +3 more sources

The efficacy and safety of ethyl methyl hydroxypyridine succinate used as part of sequential therapy in patients with chronic cerebral ischemia

Неврология, нейропсихиатрия, психосоматика, 2020
Objective: to investigate the efficacy and safety of Mexidol® FORTE 250 in patients with chronic cerebral ischemia (CCI) in the presence of hypertension and atherosclerosis.Patients and methods.
V. V. Burdakov, D. V. Krasnykh
doaj   +1 more source

The study of the endothelial protective properties of the L-norvaline combination with mexidol in the simulation of L-NAME-induced NO deficiency [PDF]

Research Results in Pharmacology, 2019
Introduction: The endothelium is considered as a target for the prevention and treatment of pathological processes leading to cardiovascular diseases. Materials and methods: Endothelial dysfunction was simulated in male rats using an e-
Elena A. Konovalova, Elena S. Chernomortseva   +1 more
doaj   +3 more sources

Hydrogen Sulfide Ameliorates Developmental Impairments of Rat Offspring with Prenatal Hyperhomocysteinemia

Oxidative Medicine and Cellular Longevity, Volume 2018, Issue 1, 2018., 2018
Maternal high levels of the redox active amino acid homocysteine—called hyperhomocysteinemia (hHCY)—can affect the health state of the progeny. The effects of hydrogen sulfide (H2S) treatment on rats with maternal hHCY remain unknown. In the present study, we characterized the physical development, reflex ontogeny, locomotion and exploratory activity ...
O. V. Yakovleva, A. R. Ziganshina, S. A. Dmitrieva, A. N. Arslanova, A. V. Yakovlev, F. V. Minibayeva, N. N. Khaertdinov, G. K. Ziyatdinova, R. A. Giniatullin, G. F. Sitdikova, Mohamed M. Abdel-Daim   +10 more
wiley   +1 more source

Coorection Of Lipid Peroxydation And Antioxydant Protective System By Mexidol And Glycine In Patients With Acute Ethanol Intoxication [PDF]

Саратовский научно-медицинский журнал, 2009
The research goal is to study lipid peroxydation and ferments of antioxidant protection in group of patients with an acute alcohol intoxication and their correction by medicaments with antioxidant activity (mexidol, glycine and their combination ...
R.S. Farshatov, R. N. Kildebekova, A.I. Savlukov   +2 more
doaj