Results 1 to 10 of about 34,162 (142)

Ethylmethylhydroxypyridine Succinate Is an Inhibitor but Not a Substrate of ABCB1 and SLCO1B1 [PDF]

Pharmaceuticals, 2023
2-Ethyl-6-methyl-3-hydroxypyridine succinate (EMHPS, Mexidol) is an original antioxidant and an anti-ischemic drug with the possibility of wide applications in the complex therapy of diseases, accompanied by the development of oxidative stress and ...
Elena Yakusheva, Ivan Chernykh, Aleksey Shchulkin   +2 more
exaly   +6 more sources

Microbiological Substantiation of the Effectiveness of Quercitin and Its Combination With Ethylmethylhydroxypyridine Succinate in the Complex Treatment of Odontogenic Phlegmon and Maxillofacial Abscesses [PDF]

Frontiers in Oral Health
Odontogenic infections can become life-threatening. The aim of the study was to determine the effectiveness of quercitin and its combination with ethylmethylhydroxypyridine succinate in the complex treatment of odontogenic infections by assessing the ...
Kateryna Lokes, Anatolii Kiptilyi, Margaryta Skikevych, Dmytro Steblovskyi, Vitaliy Lychman, Serhii Bilokon, David Avetikov   +6 more
exaly   +6 more sources

Chemotranscriptome Analysis of the Ethylmethylhydroxypyridine Succinate Molecule in the Context of Postgenomic Pharmacology [PDF]

Nevrologiya, Neiropsikhiatriya, Psikhosomatika, 2020
Postgenomic pharmacology deals with the desirable and undesirable effects of drugs in relation to the genome, transcriptome, proteome, and reactome.
Olga Gromova, I Yu Torshin
exaly   +6 more sources

MexiB 6 as a Result of Fortification of Ethylmethylhydroxypyridine Succinate With Magnesium and Pyridoxine: Proteome Effects

Nevrologiya, Neiropsikhiatriya, Psikhosomatika, 2016
The efficacy of ethylmethylhydroxypyridine succinate (EMHPS)  depends on the concentration and activity of proteomic proteins. To provide the body with magnesium and pyridoxine is an important condition for the efficacy of EMHPS because these ...
Konstantin Rudakov, Olga Gromova, A G Kalacheva   +2 more
exaly   +6 more sources

Protection of Brain Mitochondria Against Micro Stroke-Induced Injury: A Study of Ethylmethylhydroxypyridine Succinate in Experimental Model Using Two Photon Laser Fluorescent Microscopy

Epilepsy and Paroxysmal Conditions, 2016
Objective. Mitochondrial injury plays a central role in neuronal death following ischemic stroke. In the present study, we investigated effects of ethylmethylhydroxypyridine succinate on a microstroke-induced mitochondria swelling, a hallmark of ...
R. A. Afzalov, Yu. O. Kolikova, E. G. Pryazhnikov, D. V. Toptunov, L. S. Khirug   +4 more
exaly   +4 more sources

Experimental Assessment of the Toxicity of a Cardiac Drug Based on a Phosphodiesterase-3 Inhibitor and Ethylmethylhydroxypyridine Succinate

Scientific Messenger of LNU of Veterinary Medicine and Biotechnology, 2022
The study aimed to establish the parameters of chronic toxicity of the newly developed drug based on phosphodiesterase-3 inhibitor and ethylmethylhydroxypyridine succinate in experiments on laboratory animals. The analysis was performed on white sexually
Andriy Shcherbatyy, V V Parchenko, B V Gutyj   +2 more
exaly   +4 more sources

Safety of Mexidol® (Ethylmethylhydroxypyridine Succinate) in Adult Patients of Different Age Groups

Nevrologiya, Neiropsikhiatriya, Psikhosomatika, 2022
To reduce the risk of developing adverse events (AEs) and increase the adherence of elderly patients to treatment, it is recommended to limit maximally the total number of prescribed drugs (DR), using one drug for the treatment of two or more pathologies
Elena Ushkalova, S K Zyryanov, O I Butranova   +2 more
exaly   +4 more sources

Application of ethylmethylhydroxypyridine succinate in patients with the burns

Український журнал клінічної хірургії, 2023
Objective. To determine clinical efficacy of the preparation ethylmethylhydroxypyridine succinate application in early period of the burn disease. Materials and methods.
O. M. Lynnyk, G. P. Kozynets
doaj   +2 more sources

Antioxidants in treatment of kraurosis vulvae

Фундаментальная и клиническая медицина, 2022
Aim. To study impact of ethylmethylhydroxypyridine succinate, an antioxidant, on the efficacy of photodynamic therapy (PDT) of kraurosis vulvae (vulvar lichen sclerosus).Materials and Methods. The study enrolled 90 patients with kraurosis vulvae who were
E. A. Kiseleva, A. Sh. Makhmutkhodzhaev, G. A. Mikheenko   +2 more
doaj   +2 more sources

Ethylmethylhydroxypyridine Succinate, Acetylcysteine and Choline Alphoscerate Improve Mitochondrial Function Under Condition of Cerebral Ischemia in Rat

Bangladesh Journal of Pharmacology, 2019
The study was devoted to see the effect of ethylmethylhydroxypyridine succinate, acetylcysteine and choline alphoscerate on the mitochondrial function under condition of experimental cerebral ischemia in rat.
Dmitryi Igorevich Pozdnyakov
exaly   +3 more sources