Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats [PDF]
Behavioural Neurology, 2017 It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar.
Anastasiya Kasian +6 more
doaj +5 more sources
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission [PDF]
Frontiers in Pharmacology, 2016 Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action.
Svetlana Limborska +2 more
exaly +6 more sources
Neurotropic Peptid Called Selank With Antiviral Activity Against Human and Bird Influenza and Herpes Virus Infections [PDF]
Russian Journal of Infection and Immunity, 2014 . The antiviral action of Selank which is the neurotropic and psychotropic peptide has been studied. Antiviral characteristics of Selank were evaluated in both in vitro and in vivo against influenza virus strain H3N2 and H5N1 and Herpes virus 1, 2 types.
Lyudmila A Andreeva, Nikolai F Myasoedov
exaly +4 more sources
Selank effects on morphine-induced analgesia in vivo experiments [PDF]
Фармакокинетика и Фармакодинамика, 2022 Background. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the
A. V. Nadorova +2 more
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Selank and semax as potential hepatoprotectors in medical treatment of tuberculosis [PDF]
Research Results in Pharmacology, 2019 Introduction: Drug-induced hepatitis is common in clinical practice. This problem is particularly relevant in the treatment of tuberculous infection, because for this purpose, up to 5–6 hepatotoxic drugs are used simultaneously for a long time, which ...
Alexey K. Petrovsky +5 more
doaj +5 more sources
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells [PDF]
Frontiers in Pharmacology, 2017 Svetlana Limborska +2 more
exaly +4 more sources
State of rat colon microbiocenosis in chronic restraint stress treated with Selank [PDF]
Инфекция и иммунитет, 2020 It is currently accepted that stress significantly affects composition of microbiocenosis due to changes in permeability of intestinal barrier and pro-inflammatory effects. This, in turn, changes behavioral reactions, anxiety and stress response. In this
A. Yu. Mukhina +8 more
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EFFECT OF GLYPROLINES ON THE LEVEL OF APOPTOTIC AND NEUROTROPHIC FACTORS UNDER CONDITIONS OF “SOCIAL” STRESS [PDF]
Фармация и фармакология (Пятигорск), 2021 The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and ...
A. L. Yasenyavskaya +5 more
doaj +2 more sources
Russian Open Medical Journal, 2022 Objective — To examine the morphometric parameters of neurons and the oxidative status of the Wistar rat brain tissues after administering proline-containing peptides, also known as glyprolines (Arg-Gly-Arg-Pro-Gly-Pro [RGRPGP] and Thr-Lys-Pro-Arg-Pro ...
Anna A. Kolesnikova +4 more
doaj +2 more sources
Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research) [PDF]
Research Results in Pharmacology, 2020 Introduction: Tuberculosis is a widely spread infection. While treating patients for it, they are given simultaneously and for a long period 5-6 antibacterial drugs, which are, as a rule, bad for the liver.
Vladimir N. Fedorov +5 more
doaj +3 more sources