Results 1 to 10 of about 53 (48)
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. [PDF]
Behav Neurol, 2017 It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar.
Kasian A +6 more
europepmc +3 more sources
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission [PDF]
Frontiers in Pharmacology, 2016 Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action.
M I Shadrina +2 more
exaly +4 more sources
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells [PDF]
Frontiers in Pharmacology, 2017 Elena V Filatova +2 more
exaly +2 more sources
Treatment of hepatitis induced by anti-tuberculosis drugs (experimental research) [PDF]
Research Results in Pharmacology, 2020 Introduction: Tuberculosis is a widely spread infection. While treating patients for it, they are given simultaneously and for a long period 5-6 antibacterial drugs, which are, as a rule, bad for the liver.
Vladimir N. Fedorov +5 more
doaj +3 more sources
Selank effects on morphine-induced analgesia in vivo experiments
Фармакокинетика и Фармакодинамика, 2022 Background. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the
A. V. Nadorova +2 more
doaj +1 more source
Selank and semax as potential hepatoprotectors in medical treatment of tuberculosis [PDF]
Research Results in Pharmacology, 2019 Introduction: Drug-induced hepatitis is common in clinical practice. This problem is particularly relevant in the treatment of tuberculous infection, because for this purpose, up to 5–6 hepatotoxic drugs are used simultaneously for a long time, which ...
Alexey K. Petrovsky +5 more
doaj +3 more sources
Фармация и фармакология (Пятигорск), 2021 The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and ...
A. L. Yasenyavskaya +5 more
doaj +1 more source
Russian Open Medical Journal, 2022 Objective — To examine the morphometric parameters of neurons and the oxidative status of the Wistar rat brain tissues after administering proline-containing peptides, also known as glyprolines (Arg-Gly-Arg-Pro-Gly-Pro [RGRPGP] and Thr-Lys-Pro-Arg-Pro ...
Anna A. Kolesnikova +4 more
doaj +1 more source
State of rat colon microbiocenosis in chronic restraint stress treated with Selank
Инфекция и иммунитет, 2020 It is currently accepted that stress significantly affects composition of microbiocenosis due to changes in permeability of intestinal barrier and pro-inflammatory effects. This, in turn, changes behavioral reactions, anxiety and stress response. In this
A. Yu. Mukhina +8 more
doaj +1 more source
European Pharmaceutical Journal, 2022 This study is devoted to the experimental study of the immunocorrecting action of Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on the model of “social” stress formed as a result of sensory contact and inter-confrontation ...
Yasenyavskaya A.L. +3 more
doaj +1 more source