Results 1 to 10 of about 103 (75)
Comparison of the effects of three glyprolines after five days of intraperitoneal administration
The Siberian Scientific Medical JournalTo date, about 70 drugs based on regulatory peptides have been registered, including proline-containing ones, such as the nootropics Semax and Selank. Further study of the properties of glyproline peptide sequences is relevant in order to describe their ...
A A Kolesnikova, I V Tolstenok
exaly +4 more sources
The in vitro neuroprotective activity of analogues of N-terminus substituted glyprolines
Фармакокинетика и Фармакодинамика, 2020 In this work investigated the neuroprotective activity of analogues of substituted glyproline GZK-111 at the N-terminus in vitro. Oxidative stress caused by H2O2 (1.5 mM) led to significant decrease in the hippocampal cells HT-22 viability.
S. V. Nikolaev +5 more
doaj +5 more sources
Abstract Book: 25th Congress of the European Hematology Association Virtual Edition, 2020 [PDF]
Hemasphere, 2020 HemaSphere, Volume 4, Issue S1, Page 1-1168, June 2020.
europepmc +2 more sources
Neuroprotective properties of novel substituted glyprolines in vitro
Фармакокинетика и Фармакодинамика, 2019 Resume. Previously in the Zakusov Institute of Pharmacology the linear substituted glyproline GZK-111, N-phenylacetyl-glycyl-L-proline ethyl ester, which is capable to convert into the neuropeptide cyclo-prolylglycine (CPG) in biological media and ...
T. A. Antipova +5 more
doaj +2 more sources
Фармация и фармакология (Пятигорск), 2021 The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and ...
A. L. Yasenyavskaya +5 more
doaj +3 more sources
UEG Week 2014 Oral Presentations [PDF]
United European Gastroenterol J, 2014 United European Gastroenterology Journal, Volume 2, Issue S1, Page A1-A131, October 2014.
europepmc +2 more sources
GLYPROLINES AS MODULATORS OF IMMUNOREACTIVITY WITHIN CONDITIONS OF “SOCIAL” STRESS
Фармация и фармакология (Пятигорск), 2019 The most important direction in the development of modern medical science is the study of protective, compensatory and pathological reactions of the organism that occur in response to various stress factors.The aim of the study is the subsequent ...
M. A. Samotrueva +4 more
doaj +3 more sources
UEG Week 2015 Poster Presentations [PDF]
United European Gastroenterol J, 2015 United European Gastroenterology Journal, Volume 3, Issue S5, Page 146-687, October 2015.
europepmc +2 more sources
Сибирский научный медицинский журнал, 2022 The aim of the study was to compare the effect of glyproline peptides RGRGP (Arg-Gly-Arg-Gly-Pro), RGP (Arg-GlyPro), PRPGP (Pro-Arg-Pro-Gly-Pro) and PGPL (Pro-Gly-Pro-Leu) peptide substances at various concentrations on the free radical oxidation ...
A. A. Kolesnikova +7 more
doaj +1 more source
Mechanisms for glyproline protection in hypercholesterolemia
Pathophysiology, 2016 Comparative analysis of the hypocholesterolemic and antithrombotic action of small regulatory glyproline peptides (Pro-Gly-Pro, Arg-Pro-Gly-Pro and Pro-Gly-Pro-Leu) was performed on an experimental hypercholesterolemia model of rats. Repeated intranasal introduction of glyproline peptides to fat-diet-fed animals led to more active functioning of the ...
Nikolay F, Myasoedov +5 more
+6 more sources