Results 1 to 10 of about 130 (77)

The in vitro neuroprotective activity of analogues of N-terminus substituted glyprolines

Фармакокинетика и Фармакодинамика, 2020
In this work investigated the neuroprotective activity of analogues of substituted glyproline GZK-111 at the N-terminus in vitro. Oxidative stress caused by H2O2 (1.5 mM) led to significant decrease in the hippocampal cells HT-22 viability.
S. V. Nikolaev, I. O. Logvinov, K. N. Koliasnikova, E. A. Kuznetsova, P. I. Antipov, T. A. Antipova   +5 more
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Neuroprotective properties of novel substituted glyprolines in vitro [PDF]

Фармакокинетика и Фармакодинамика, 2019
Resume. Previously in the Zakusov Institute of Pharmacology the linear substituted glyproline GZK-111, N-phenylacetyl-glycyl-L-proline ethyl ester, which is capable to convert into the neuropeptide cyclo-prolylglycine (CPG) in biological media and ...
T. A. Antipova, K. N. Kolyasnikova, Y. S. Volkova, P. I. Antipov, E. A. Kuznetsova, S. V. Nikolaev   +5 more
doaj   +5 more sources

GLYPROLINES AS MODULATORS OF IMMUNOREACTIVITY WITHIN CONDITIONS OF “SOCIAL” STRESS [PDF]

Фармация и фармакология (Пятигорск), 2019
The most important direction in the development of modern medical science is the study of protective, compensatory and pathological reactions of the organism that occur in response to various stress factors.The aim of the study is the subsequent ...
M. A. Samotrueva, A. L. Yasenyavskaya, O. A. Bashkina, N. F. Myasoedov, L. A. Andreeva   +4 more
doaj   +4 more sources

EFFECT OF GLYPROLINES ON THE LEVEL OF APOPTOTIC AND NEUROTROPHIC FACTORS UNDER CONDITIONS OF “SOCIAL” STRESS [PDF]

Фармация и фармакология (Пятигорск), 2021
The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and ...
A. L. Yasenyavskaya, A. A. Tsibizova, L. A/ Andreeva, N. F. Myasoedov, O. A. Bashkina, M. A. Samotrueva   +5 more
doaj   +5 more sources

Evaluating some parameters of Wistar rat brain in traumatic brain injury model with administration of proline-containing peptides

Russian Open Medical Journal, 2022
Objective — To examine the morphometric parameters of neurons and the oxidative status of the Wistar rat brain tissues after administering proline-containing peptides, also known as glyprolines (Arg-Gly-Arg-Pro-Gly-Pro [RGRPGP] and Thr-Lys-Pro-Arg-Pro ...
Anna A. Kolesnikova, Marina Yu. Fleishman, Yulia B. Malofey, Natalya Yu. Yakusheva, Ivan V. Tolstenok   +4 more
doaj   +3 more sources

Glyprolines: Regulatory peptides with an integrative action

Integrative Physiology, 2020
A series of C-substituted N-phenylacetylglycylprolines were synthesized. Their structure-activity (antihypoxic) relationship was studied in normobaric hypoxia tests at i.p. doses of 0.1 – 1 mg/kg as a function of the C-substitution. The amide and ethyl ester of N-phenylacetylglycyl-L-proline exhibited antihypoxic activity and could cyclize in ...
K. N. Kolyasnikova, E. A. Kuznetsova, S. V. Nikolaev, T. A. Antipova, T. A. Gudasheva, S. B. Seredenin   +5 more
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Mechanisms for glyproline protection in hypercholesterolemia

Pathophysiology, 2016
Comparative analysis of the hypocholesterolemic and antithrombotic action of small regulatory glyproline peptides (Pro-Gly-Pro, Arg-Pro-Gly-Pro and Pro-Gly-Pro-Leu) was performed on an experimental hypercholesterolemia model of rats. Repeated intranasal introduction of glyproline peptides to fat-diet-fed animals led to more active functioning of the ...
Nikolay F, Myasoedov, Ludmila A, Lyapina, Marina E, Grigorjeva, Tamara Y, Obergan, Tatyana A, Shubina, Ludmila A, Andreeva   +5 more
core   +6 more sources

Effects of glyprolines on free-radical oxidation in the brain neocortex of white rats in mild traumatic brain injury [PDF]

Сибирский научный медицинский журнал, 2022
The aim of the study was to compare the effect of glyproline peptides RGRGP (Arg-Gly-Arg-Gly-Pro), RGP (Arg-GlyPro), PRPGP (Pro-Arg-Pro-Gly-Pro) and PGPL (Pro-Gly-Pro-Leu) peptide substances at various concentrations on the free radical oxidation ...
A. A. Kolesnikova, Yu. B. Malofey, N. Yu. Yakusheva, I. V. Tolstenok, O. V. Demidova, L. A. Andreeva, N. F. Myasoedov, M. Yu. Fleishman   +7 more
doaj   +2 more sources

The modern view on the role of glyprolines by metabolic syndrome

Medicinal Research Reviews, 2020
AbstractThe analysis of the literature data and own experimental studies on the effect of glyproline peptides on fat, carbohydrate metabolism, and hemostasis system when modeling metabolic syndrome in animals (rats) was carried out. Violations of fat and carbohydrate metabolism are characterized by hypercoagulation, increased glucose levels ...
Nikolai F, Myasoedov, Lyudmila A, Lyapina, Lyudmila A, Andreeva, Marina E, Grigorieva, Tamara Y, Obergan, Tatiana A, Shubina   +5 more
openaire   +4 more sources

Comparison of the effects of three glyprolines after five days of intraperitoneal administration

Сибирский научный медицинский журнал
To date, about 70 drugs based on regulatory peptides have been registered, including proline-containing ones, such as the nootropics Semax and Selank. Further study of the properties of glyproline peptide sequences is relevant in order to describe their ...
A. A. Kolesnikova, M. Yu. Fleishman, Yu. B. Malofey, I. V. Tolstenok, N. V. Duzenko, A. A. Salnikov   +5 more
doaj   +2 more sources