Results 41 to 50 of about 130 (77)
Arginine-containing peptides and their influenceon normal hemostatic parameters in rats
, 2019 М.Е. Григорьева +2 more
core +1 more source
Glyprolines in Regulatory Tripeptides
Neurochemical Journal, 2007 Glyprolines widely occur in structures of regulatory oligopeptides with a wide spectrum of bioactivities. The role of glyprolines is most significant in regulatory tripeptides. They participate in the stabilization of regulatory oligopeptides in organisms and in the generation of a complex new spectra of bioactivities. Gly-Pro-Glu, Gly-Pro-Leu, Leu-Gly-
I P Ashmarin
exaly +3 more sources
Effect of Glyprolines on Homeostasis of Gastric Mucosa in Rats With Stress Ulcers
Bulletin of Experimental Biology and Medicine, 2010 Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in this respect.
G E Samonina
exaly +4 more sources
Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery
Bulletin of Experimental Biology and Medicine, 2003 One-hour immobilization stress considerably disturbed microcirculation in the mesentery: blood flow in small mesenteric vessels decreased or stopped and numerous hemorrhages appeared. Lymphatic vessels lost spontaneous activity and did not respond to norepinephrine.
G N Kopylova, G E Samonina, B A Umarova
exaly +4 more sources
Effects of Glyprolines on Stress-Induced Behavioral Disorders in Rats
Neuroscience and Behavioral Physiology, 2006 We report here studies on the antistress protective actions of three peptides of the glyproline family: Pro-Gly-Pro, Pro-Gly, and Gly-Pro. Stress (10 min forced swimming) evoked typical changes in the behavioral activity of rats in the elevated cross maze and hole board tests, providing evidence of a significant increase in anxiety and a decrease in ...
G N Kopylova, G E Samonina, B A Umarova
exaly +4 more sources
Russian Journal of Bioorganic Chemistry, 2008 The distribution of the glyprolines, Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc), was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes of concentrations of the peptides in the rat organs after their intraperitoneal ...
G N Kopylova, V S Kozik, G E Samonina
exaly +3 more sources
Bulletin of Experimental Biology and Medicine, 2007 Glyprolines (PGP, GPG, GPGP, PGPGP, and GPGPGP) modulated histomorphological characteristics of acetate ulcers. They accelerated healing of acetate ulcers, promote complete differentiation of the surface epithelium and glands in the gastric mucosa, contributed to the appearance of a considerable number of fibroblasts at the site of the regenerating ...
Zanda Bakaeva +2 more
exaly +4 more sources
Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects
Bulletin of Experimental Biology and Medicine, 2018 We studied the effects of intraperitoneal administration of L-arginine in doses of 5, 15, and 50 μg/kg and peptides in doses containing equimolar amount of this amino acid on aggressive-defensive behavior of rats (footshock model). The peptides were synthesized by binding of Pro-Gly-Pro sequence to one or both ends of the L-arginine molecule.
L А, Sever'yanova, D V, Plotnikov
exaly +4 more sources
Bulletin of Experimental Biology and Medicine, 2007 Experiments on male outbred albino rats showed that stress (10-min swimming) increased anxiety and inhibited orientation and exploratory activities. Poststress (15 min after the end of swimming) intranasal administration of peptides Pro-Gly-Pro and Gly-Pro in a dose of 3.7 micromol/kg prevented stress-induced behavioral disorders. This effect persisted
Zanda Bakaeva +2 more
exaly +4 more sources
Bulletin of Experimental Biology and Medicine, 2003 Peroral administration of peptide Pro-Gly-Pro to 10-11-month-old rats with modeled prethrombotic state normalized functions of the anticoagulation system and produced a potent antiplatelet effect. Peroral administration of Pro-Gly peptide before provocation of thrombin generation and thrombus formation prevented death of animals from thrombosis ...
V E Pastorova, L A Lyapina, I P Ashmarin
exaly +4 more sources