Results 41 to 50 of about 103 (75)
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Glyprolines in regulatory tripeptides
Neurochemical Journal, 2007Glyprolines widely occur in structures of regulatory oligopeptides with a wide spectrum of bioactivities. The role of glyprolines is most significant in regulatory tripeptides. They participate in the stabilization of regulatory oligopeptides in organisms and in the generation of a complex new spectra of bioactivities. Gly-Pro-Glu, Gly-Pro-Leu, Leu-Gly-
Ashmarin I P
exaly +2 more sources
Effect of Glyprolines on Homeostasis of Gastric Mucosa in Rats with Stress Ulcers
Bulletin of Experimental Biology and Medicine, 2010Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in this respect.
G E Samonina, Samonina G E, Andreeva L A
exaly +3 more sources
Glyprolines and Semax Prevent Stress-Induced Microcirculatory Disturbances in the Mesentery
Bulletin of Experimental Biology and Medicine, 2003One-hour immobilization stress considerably disturbed microcirculation in the mesentery: blood flow in small mesenteric vessels decreased or stopped and numerous hemorrhages appeared. Lymphatic vessels lost spontaneous activity and did not respond to norepinephrine.
G N Kopylova, E A Smirnova, B A Umarova
exaly +3 more sources
Bulletin of Experimental Biology and Medicine, 2007
Glyprolines (PGP, GPG, GPGP, PGPGP, and GPGPGP) modulated histomorphological characteristics of acetate ulcers. They accelerated healing of acetate ulcers, promote complete differentiation of the surface epithelium and glands in the gastric mucosa, contributed to the appearance of a considerable number of fibroblasts at the site of the regenerating ...
Z V Bakaeva, G E Samonina, A A Guseva
exaly +3 more sources
Glyprolines (PGP, GPG, GPGP, PGPGP, and GPGPGP) modulated histomorphological characteristics of acetate ulcers. They accelerated healing of acetate ulcers, promote complete differentiation of the surface epithelium and glands in the gastric mucosa, contributed to the appearance of a considerable number of fibroblasts at the site of the regenerating ...
Z V Bakaeva, G E Samonina, A A Guseva
exaly +3 more sources
Effects of glyprolines on stress-induced behavioral disorders in rats
Neuroscience and Behavioral Physiology, 2006We report here studies on the antistress protective actions of three peptides of the glyproline family: Pro-Gly-Pro, Pro-Gly, and Gly-Pro. Stress (10 min forced swimming) evoked typical changes in the behavioral activity of rats in the elevated cross maze and hole board tests, providing evidence of a significant increase in anxiety and a decrease in ...
G N Kopylova, G E Samonina, B A Umarova
exaly +3 more sources
Russian Journal of Bioorganic Chemistry, 2008
The distribution of the glyprolines, Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc), was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes of concentrations of the peptides in the rat organs after their intraperitoneal ...
Yu A Zolotarev, V S Kozik, L Yu Alfeeva
exaly +2 more sources
The distribution of the glyprolines, Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc), was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes of concentrations of the peptides in the rat organs after their intraperitoneal ...
Yu A Zolotarev, V S Kozik, L Yu Alfeeva
exaly +2 more sources
Bulletin of Experimental Biology and Medicine, 2003
Peroral administration of peptide Pro-Gly-Pro to 10-11-month-old rats with modeled prethrombotic state normalized functions of the anticoagulation system and produced a potent antiplatelet effect. Peroral administration of Pro-Gly peptide before provocation of thrombin generation and thrombus formation prevented death of animals from thrombosis ...
V E Pastorova, L A Lyapina, I P Ashmarin
exaly +3 more sources
Peroral administration of peptide Pro-Gly-Pro to 10-11-month-old rats with modeled prethrombotic state normalized functions of the anticoagulation system and produced a potent antiplatelet effect. Peroral administration of Pro-Gly peptide before provocation of thrombin generation and thrombus formation prevented death of animals from thrombosis ...
V E Pastorova, L A Lyapina, I P Ashmarin
exaly +3 more sources
Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects
Bulletin of Experimental Biology and Medicine, 2018We studied the effects of intraperitoneal administration of L-arginine in doses of 5, 15, and 50 μg/kg and peptides in doses containing equimolar amount of this amino acid on aggressive-defensive behavior of rats (footshock model). The peptides were synthesized by binding of Pro-Gly-Pro sequence to one or both ends of the L-arginine molecule.
L А, Sever'yanova, D V, Plotnikov
exaly +3 more sources
Moscow University Biological Sciences Bulletin, 2013
The effects of glyprolines (PGP and N-acetyl-PGP) on the expression of cytokine genes in the ethanol ulcer formation model have been investigated. Determination of the activity of mRNA in peripheral blood mononuclear cells has been performed using methods of reverse transcription and polymerase chain reaction. It has been shown that, in control animals,
Z V Bakaeva, G E Samonina, A A Guseva
exaly +2 more sources
The effects of glyprolines (PGP and N-acetyl-PGP) on the expression of cytokine genes in the ethanol ulcer formation model have been investigated. Determination of the activity of mRNA in peripheral blood mononuclear cells has been performed using methods of reverse transcription and polymerase chain reaction. It has been shown that, in control animals,
Z V Bakaeva, G E Samonina, A A Guseva
exaly +2 more sources
Bulletin of Experimental Biology and Medicine, 2008
Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4 (100 microg/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests, and increased the level of depression of Porsolt test.
G N Kopylova, Z V Bakaeva, G E Samonina
exaly +3 more sources
Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4 (100 microg/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests, and increased the level of depression of Porsolt test.
G N Kopylova, Z V Bakaeva, G E Samonina
exaly +3 more sources