Results 51 to 60 of about 130 (77)
Bulletin of Experimental Biology and Medicine, 2008 Experiments on outbred albino male rats showed that psychoemotional stress induced by intraperitoneal injection of cholecystokinin-4 (100 microg/kg) increased anxiety, impaired orientation and exploration activities in the elevated plus-maze and hole-board tests, and increased the level of depression of Porsolt test.
Zanda Bakaeva +2 more
exaly +4 more sources
Biological Effects of Glyprolines Melanocortin Series
Pharmateca, 2018 L.V. Gubsky () Gubsky +5 more
exaly +3 more sources
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Effect of Glyprolines on Norepinephrine Tone of Isolated Rat Aortic Rings
Bulletin of Experimental Biology and Medicine, 2003Glyprolines, short proline-containing peptides (Pro-Gly-Pro, Pro-Gly, and Gly-Pro) in concentrations of 10(-8)-10(-4) M decreased norepinephrine tone of the isolated rat aortic rings. The vasodilatory effect of Pro-Gly-Pro and Pro-Gly was associated with NO release from endotheliocytes, while Gly-Pro directly affected vascular smooth muscle cells.
Zanda Bakaeva, G E Samonina
exaly +3 more sources
Russian Journal of Bioorganic Chemistry, 2009 A synthetic scheme for preparation of (Gly-Pro)n, (Pro-Gly)n (n = 2, 3), and (Pro-Gly-Pro)n (n = 1, 2) peptides was elaborated. The effect of the synthesized peptides and the Gly-Pro and Pro-Gly dipeptides on survival of cultured cells of PC12 rat pheochromocytoma was studied under the conditions of oxidative stress induced by brief incubation of the ...
K V, Martynova +8 more
openaire +3 more sources
Moscow University Biological Sciences Bulletin, 2013
The effects of glyprolines (PGP and N-acetyl-PGP) on the expression of cytokine genes in the ethanol ulcer formation model have been investigated. Determination of the activity of mRNA in peripheral blood mononuclear cells has been performed using methods of reverse transcription and polymerase chain reaction. It has been shown that, in control animals,
Zanda Bakaeva +2 more
exaly +2 more sources
The effects of glyprolines (PGP and N-acetyl-PGP) on the expression of cytokine genes in the ethanol ulcer formation model have been investigated. Determination of the activity of mRNA in peripheral blood mononuclear cells has been performed using methods of reverse transcription and polymerase chain reaction. It has been shown that, in control animals,
Zanda Bakaeva +2 more
exaly +2 more sources
Тромбоз, гемостаз и реология, 2019 Введение. Метаболический синдром (МС) сопровождается гиперлипемией, гиперкоагуляцией, дисфункцией эндотелия и др. В связи с этим не вызывает сомнений актуальность поиска новых средств комбинированного действия, восстанавливающих как жировой обмен, так и нормальную функцию эндотелия и сосудистотромбоцитарный гемостаз.
М.Е. Григорьева +2 more
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Biology Bulletin, 2015
The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in ...
Alla A Shabalina, Marine Tanashyan
exaly +3 more sources
The lipid-lowering, fibrinolytic, and anticoagulant effects of leucine-containing glyprolines, Pro-Gly-Pro-Leu and Leu-Pro-Gly-Pro, were studied in vitro in the blood of patients with disorders of lipid metabolism. The lipid-lowering impact of glyprolines and their ability to reduce the polymerization and to increase the depolymerization of fibrin in ...
Alla A Shabalina, Marine Tanashyan
exaly +3 more sources
Molecular modelling of Pro-Gly glyproline and its complexes
Vestnik Moskovskogo Universiteta, Seriya 3: Fizika, Astronomiya, 2023In the present work, Pro-Gly glyproline and its biologically active complexes with heparin and with the antithrombin-heparin protein complex have been studied using molecular modelling methods. This molecule is used as a drug and exhibits antithrombotic, anticoagulant immunomodulatory, antiulcer, and antidiabetic effects. The conformational profiles of
L. I. Ismailova +3 more
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Аnticoagulation Effects of Leucine-Containing Glyprolines in Hypercoagulation
Biology Bulletin, 2023The effects of two leucine-containing glyproline peptides Leu-Pro-Gly-Pro and Pro-Gly-Pro-Leu, including leucine from the N- and C-ends of the molecules, on the parameters of platelet (primary) and plasma hemostasis were studied. Peptides were administered intranasally for 5 days at a daily dose of 500 mcg/kg of body weight under conditions of ...
M. E. Grigorieva +2 more
openaire +1 more source