Results 61 to 70 of about 103 (75)

Structural-functional study of glycine-and-proline-containing peptides (Glyprolines) as potential neuroprotectors

Russian Journal of Bioorganic Chemistry, 2009
A synthetic scheme for preparation of (Gly-Pro)n, (Pro-Gly)n (n = 2, 3), and (Pro-Gly-Pro)n (n = 1, 2) peptides was elaborated. The effect of the synthesized peptides and the Gly-Pro and Pro-Gly dipeptides on survival of cultured cells of PC12 rat pheochromocytoma was studied under the conditions of oxidative stress induced by brief incubation of the ...
K V, Martynova, L A, Andreeva, P A, Klimova, Iu G, Kirillova, V P, Shevchenko, I Iu, Nagaev, I Iu, Shram, V I, Shvets, N F, Miasoedov   +8 more
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EVALUATION OF IMMUNOTROPIC PROPERTIES OF GLYPROLINE COMPOUNDS IN EXPERIMENTAL HYPERTHYROIDISM

Molekulyarnaya Meditsina (Molecular medicine)
Introduction. Thyroid disease is currently the most common among endocrine pathology. Hyperproduction of thyroid hormones is accompanied by stimulation of humoral reactions, contributing to the development of immune-mediated pathology under certain conditions, which actualizes the need to develop means for correcting neuroimmunoendocrine processes ...
M.U. Sergalieva, A.A. Tsibizova, V.Kh. Murtalieva, L.A. Andreeva, N.F. Myasoedov, M.A. Samotrueva   +5 more
openaire   +1 more source

[Pharmacokinetics of glyprolines (PGP) upon intragastric administration].

Eksperimental'naia i klinicheskaia farmakologiia, 2005
The pharmacokinetics of glyprolines upon intragastric administration in rats was studied by monitoring the content of tritium-labeled PGP in the blood plasma and protein, in organs (for 5 h), and urine (for 8 h). The maximum radioactivity (2.25% of the introduced level) in the blood plasma was observed 15 min after administration of [3H]-PGP. Then, the
Z V, Bakaevea, G E, Samonina, L A, Andreeva, Iu A, Zolotarev, V S, Kozik, I P, Ashmarin, N F, Miasoedov   +6 more
openaire   +1 more source

[The effect of glyprolines on stressogenic disorders in the rat behaviour].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2005
Protective and antistress effects of three glyprolines--PGP, PG and GP, were studied. Stress influences produced typical changes of behavioural activity of rats in the elevated pluz-maze and the hole-board tests. These changes suggest a significant enhancement of anxiety and a drop of the level of orientation-investigative activity.
S E, Badmaeva, G N, Kopylova, N N, Abushinova, G E, Samonina, B A, Umarova   +4 more
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REGULATION OF HEMOSTASIS FUNCTIONS BY GLYPROLIN PEPTIDES AT METABOLIC SYNDROME IN RATS

Тромбоз, гемостаз и реология, 2017
Цель исследования: изучение влияния регуляторных пептидов глипролинового ряда на состояние системы гемостаза в условиях in vivo на модели крыс с экспериментальным метаболическим синдромом (МС). Материалы и методы. Эксперимент проводили на 60 беспородных белых крысах-самцах с массой тела 200±10 г в возрасте 2 месяца к началу опыта (к началу кормления ...
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[Effects of glyprolines on development and healing of acetate ulcers in rats].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2005
We studied glyprolines influence on development and healing of acetate ulcers in rats. A maximal ulcer area has developed four days after application of acetic acid to gastric serous mucosa. Estimation of ulcer area in the control and experimental animals receiving a physiological solution or peptides was carried out on day 4 or 7 after ulcerogenesis ...
Z V, Bakaeva, G E, Samonina
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Regulation of primary hemostasis and vascular endothelial function by glyprolines in metabolic syndrome

Тромбоз, гемостаз и реология, 2019
Введение. Метаболический синдром (МС) сопровождается гиперлипемией, гиперкоагуляцией, дисфункцией эндотелия и др. В связи с этим не вызывает сомнений актуальность поиска новых средств комбинированного действия, восстанавливающих как жировой обмен, так и нормальную функцию эндотелия и сосудистотромбоцитарный гемостаз.
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[A comparative analysis of distribution of glyprolines administered by various routes].

Bioorganicheskaia khimiia, 2008
The distribution of the glyprolines Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc) was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes in concentrations of the peptides in the rat organs after their intraperitoneal ...
I P, Ashmarin, K E, Baglikova, S E, Edeeva, Iu A, Zolotarev, V S, Kozik, A K, Dadaian, E M, Dorokhova, L Iu, Alfeeva, L A, Andreeva, G N, Kopylova, T S, Pavlov, B V, Vas'kovskiĭ, V K, Meshavkin, O Iu, Sokolov, N V, Kost, A A, Zozulia, G E, Samonina, N F, Miasoedov   +17 more
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The modern view on the role of glyprolines by metabolic syndrome

Medicinal Research Reviews, 2021
N F Myasoedov, L A Andreeva, T Yu Obergan   +2 more
exaly  

[Semax and some glyproline peptides accelerate the healing of acetic ulcers in rats].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2004
Previously we showed that peptides PGP, PG, GP and semax have protective anti-ulcer properties using different models of ulcerogenesis. Semax (MEHFPGP) is a nootropic analogue of adrenocorticotropin 4-7 stabilized by PGP in the C-terminal region. In this study we examined the impact of these peptides on the development and healing of acetic ulcers in ...
S E, Zhuĭkova, K E, Badmaeva, G E, Samonina, L G, Plesskaia   +3 more
openaire   +1 more source