Results 61 to 70 of about 130 (77)

The synthesis and study of simple glyprolines

Neurochemical Journal, 2016
We validated the structure and performed synthesis of eight new peptides that are analogues of proglyprol, with the common formula of Pro(X)-A-Pro(Y). Here we present data on the molecular ligand-receptor activity of these peptide compounds; in particular, we present data on their ability to compete with the tripepetide Pro-Gly-Pro for specific binding
T. V. V’yunova, L. A. Andreeva, K. V. Shevchenko, V. P. Shevchenko, N. F. Myasoedov   +4 more
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Participation of Nitric Oxide in the Realization of Hemostatic Effects of Glyproline Peptides

Doklady Biochemistry and Biophysics, 2022
The involvement of nitric oxide in the responses of the hemostasis system to the appearance of proline-containing peptides in the blood was studied in experiments on rats. It was shown that a single intranasal administration of peptides PGP, RPGP, and PGPL to rats led to an increase in fibrinolytic, anticoagulant, and antiplatelet potential of blood ...
M E, Grigorieva, N F, Myasoedov, L A, Lyapina   +2 more
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Deuterium labeling of glyprolines by isotope exchange

Doklady Chemistry, 2016
Deuterium-labeled 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-Pro-NH2, and Phe-Pro-LeuPro-Ala were synthesized. The effect of the method of peptide deposition on the catalyst, the catalyst nature, temperature, and structure of peptides on the inclusion of deuterium with the formation of the appropriate number of isotopomers was demonstrated. The 5-oxo-Pro-
V. P. Shevchenko, I. Yu. Nagaev, K. V. Shevchenko, N. F. Myasoedov   +3 more
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STRUCTURAL ORGANIZATION OF THE GLYPROLINE HEXAPEPTIDE MOLECULE

Russian Journal of Biological Physics and Chemisrty
Computer modeling based on the use of the method of theoretical conformational analysis and programs that allow obtaining a graphic image of the spatial structures of biomolecules was performed for a hexapeptide molecule – glyproline H-Phe-Gly-Gly-Phe-Gly-Pro-OH.
L. Ismailova, N. Akhmedov
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EVALUATION OF IMMUNOTROPIC PROPERTIES OF GLYPROLINE COMPOUNDS IN EXPERIMENTAL HYPERTHYROIDISM

Molekulyarnaya Meditsina (Molecular medicine)
Introduction. Thyroid disease is currently the most common among endocrine pathology. Hyperproduction of thyroid hormones is accompanied by stimulation of humoral reactions, contributing to the development of immune-mediated pathology under certain conditions, which actualizes the need to develop means for correcting neuroimmunoendocrine processes ...
M.U. Sergalieva, A.A. Tsibizova, V.Kh. Murtalieva, L.A. Andreeva, N.F. Myasoedov, M.A. Samotrueva   +5 more
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[Pharmacokinetics of glyprolines (PGP) upon intragastric administration].

Eksperimental'naia i klinicheskaia farmakologiia, 2005
The pharmacokinetics of glyprolines upon intragastric administration in rats was studied by monitoring the content of tritium-labeled PGP in the blood plasma and protein, in organs (for 5 h), and urine (for 8 h). The maximum radioactivity (2.25% of the introduced level) in the blood plasma was observed 15 min after administration of [3H]-PGP. Then, the
Z V, Bakaevea, G E, Samonina, L A, Andreeva, Iu A, Zolotarev, V S, Kozik, I P, Ashmarin, N F, Miasoedov   +6 more
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[The effect of glyprolines on stressogenic disorders in the rat behaviour].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2005
Protective and antistress effects of three glyprolines--PGP, PG and GP, were studied. Stress influences produced typical changes of behavioural activity of rats in the elevated pluz-maze and the hole-board tests. These changes suggest a significant enhancement of anxiety and a drop of the level of orientation-investigative activity.
S E, Badmaeva, G N, Kopylova, N N, Abushinova, G E, Samonina, B A, Umarova   +4 more
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REGULATION OF HEMOSTASIS FUNCTIONS BY GLYPROLIN PEPTIDES AT METABOLIC SYNDROME IN RATS

Тромбоз, гемостаз и реология, 2017
Цель исследования: изучение влияния регуляторных пептидов глипролинового ряда на состояние системы гемостаза в условиях in vivo на модели крыс с экспериментальным метаболическим синдромом (МС). Материалы и методы. Эксперимент проводили на 60 беспородных белых крысах-самцах с массой тела 200±10 г в возрасте 2 месяца к началу опыта (к началу кормления ...
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[Effects of glyprolines on development and healing of acetate ulcers in rats].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2005
We studied glyprolines influence on development and healing of acetate ulcers in rats. A maximal ulcer area has developed four days after application of acetic acid to gastric serous mucosa. Estimation of ulcer area in the control and experimental animals receiving a physiological solution or peptides was carried out on day 4 or 7 after ulcerogenesis ...
Z V, Bakaeva, G E, Samonina
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[A comparative analysis of distribution of glyprolines administered by various routes].

Bioorganicheskaia khimiia, 2008
The distribution of the glyprolines Pro-Gly-Pro and Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selanc) was analyzed and compared in tissues of rat organs after different ways of their administration using the peptides uniformly labeled with tritium. Comparative data on changes in concentrations of the peptides in the rat organs after their intraperitoneal ...
I P, Ashmarin, K E, Baglikova, S E, Edeeva, Iu A, Zolotarev, V S, Kozik, A K, Dadaian, E M, Dorokhova, L Iu, Alfeeva, L A, Andreeva, G N, Kopylova, T S, Pavlov, B V, Vas'kovskiĭ, V K, Meshavkin, O Iu, Sokolov, N V, Kost, A A, Zozulia, G E, Samonina, N F, Miasoedov   +17 more
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