Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. [PDF]
ACS Chem Neurosci, 2022 Alzheimer’s disease, the most common form of dementia, is characterized by the aggregation of amyloid beta protein (Aβ). The aggregation and toxicity of Aβ are strongly modulated by metal ions and phospholipidic membranes. In particular, Cu2+ ions play a
Sciacca MFM +3 more
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Immunomodulatory and neurotropic activities of synthetic peptides in a model of brain injury in rats [PDF]
Медицинская иммунология, 2023 Treatment of consequences of traumatic brain injury (TBI) remains one of the current problems of medicine. To increase the effectiveness of treatment of post-traumatic complications, various drugs are recommended, including the peptide with ...
N. B. Serebryanaya +5 more
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Semax intranasal improve memory deficiency in conditions of experimental chronic brain ischemia [PDF]
Journal of Education, Health and SportStatistical indexes of the incidence of acute cerebrovascular accidents in our country highlight the negative dynamics of the progressive increase in the number of new cases of strokes.
V. Kirchev
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Synthesis and characteristic of photoactive arylazide semax and pro-gly-pro peptide derivatives.
Тонкие химические технологии, 2008 The photoaffine arylazide derivatives of peptides semax and Pro-Gly-Pro have been synthesized. It was shown that these compounds have cytoptotective action in culture of PC12 cells under conditions of oxidative stress.
K. V. Martynova +4 more
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Motor activity and neurological deficit restoration as the result of combined semax and hopantenic acid influence in experimental chronic brain ischemia [PDF]
Journal of Education, Health and SportThe prevalence and incidence of cerebrovascular pathology, especially chronic progressive forms, is constantly increasing in modern conditions. Treatment of chronic forms of cerebral blood supply insufficiency is of particular relevance.
V. Kirchev
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Медицинский совет, 2014 Health status of infants with extremely low and very low birth weight is a challenge for today's healthcare. Ivanovo Research Institute of Maternity and Childhood named after V.N.
T. V. Samsonova +3 more
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SEMAX - APPLICATION PROSPECTS (brief overview message)
Clinical Medicine and Pharmacology, 2021 A brief overview report on the materials of domestic research, as a priority, shows a brief history of the study of regulatory peptides, in particular Semax. The need to continue scientific research in this direction is due, in addition to somatoform and psychosomatic diseases, complications of var-ious diseases in the form of memory impairment, a ...
Elena Belyaeva, K. Hadarceva
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Effect of intranasal and intraperitoneal administration of peptides Semax and Noopept on the behavior of BALB/c mice [PDF]
Фармакокинетика и Фармакодинамика, 2016 Effects of intraperitoneal and intranasal administration of peptides noopept (1 mcg/kg/day for 5 days) and semax (0,6 mcg/ kg/day for 5 days), known to produce nootropic and anxiolytic actions were tested in BALB/c mice (the Line is characterized by ...
E. V. Vasilieva +2 more
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NEUROPROTECTIVE PROPERTIES OF NEUROPEPTIDES
Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2017 The main mechanisms of action of neuropeptides are regulation of energy metabolism and redox-balance of brain tissue, neurotrophic effects and modulation of activity of endogenous growth factors, interaction with systems of neuropeptides and ...
Kanunnikova N. P.
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Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion. [PDF]
Int J Mol Sci, 2021 The Semax (Met-Glu-His-Phe-Pro-Gly-Pro) peptide is a synthetic melanocortin derivative that is used in the treatment of ischemic stroke. Previously, studies of the molecular mechanisms underlying the actions of Semax using models of cerebral ischemia in ...
Sudarkina OY +12 more
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